Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease

Williamson, Jordan; James, Shirley A.; Mukli, Peter; Yabluchanskiy, Andriy; Wu, Dee H.; Sonntag, William; ,; Yang, Yuan

doi:10.1007/s11357-023-00943-x

Cited by 7 publications

(2 citation statements)

References 43 publications

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“…The development of Alzheimer’s disease [ 69 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ] and the mechanisms through which the microbiome can contribute to the progression of Alzheimer’s disease have been investigated [ 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 ]. Numerous studies are also available regarding treatments with probiotics […”

Section: Discussionmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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Recent research exploring the relationship between the gut and the brain suggests that the condition of the gut microbiota can influence cognitive health. A well-balanced gut microbiota may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, and symbiotics are nutritional supplements and functional food components associated with gastrointestinal well-being. The bidirectional communication of the gut–brain axis is essential for maintaining homeostasis, with pre-, pro-, and symbiotics potentially affecting various cognitive functions such as attention, perception, and memory. Numerous studies have consistently shown that incorporating pre-, pro-, and symbiotics into a healthy diet can lead to improvements in cognitive functions and mood. Maintaining a healthy gut microbiota can support optimal cognitive function, which is crucial for disease prevention in our fast-paced, Westernized society. Our results indicate cognitive benefits in healthy older individuals with probiotic supplementation but not in healthy older individuals who have good and adequate levels of physical activity. Additionally, it appears that there are cognitive benefits in patients with mild cognitive impairment and Alzheimer’s disease, while mixed results seem to arise in younger and healthier individuals. However, it is important to acknowledge that individual responses may vary, and the use of these dietary supplements should be tailored to each individual’s unique health circumstances and needs.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Fekete,

Lehoczki,

Major

et al. 2024

Nutrients

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show abstract

“…Aging in the brain is characterized by a vast array of functional and structural alterations of the microcirculation ( Schulz et al, 2022 ; Negri et al, 2023 ), contributing to the pathogenesis of age-related diseases including vascular cognitive impairment, Alzheimer’s disease, and mild cognitive impairment ( Williamson et al, 2024 ). Growing interest and understanding of the role of the aging vasculature in the context of the age-related loss of cognitive function ( Gorelick et al, 2011 ) has prompted many investigative efforts to better understand the macro and microvascular mechanisms underlying the development of dementia ( Yabluchanskiy et al, 2021 ).…”

mentioning

confidence: 99%

Editorial: Effects of vascular function and aging on brain circulation and neurodegeneration

Petersen,

Negri,

Milan

et al. 2024

Front. Aging

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Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review

Mohammadi,

Ghaderi,

Fatehi

2024

Aging Medicine

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Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral and body iron dysregulation and accumulation interact with AD pathology, particularly in the precuneus, a crucial functional hub in cognitive functions. Quantitative susceptibility mapping (QSM), a novel post‐processing approach, provides insights into tissue iron levels and cerebral oxygen metabolism and reveals abnormal iron accumulation early in AD. Increased iron deposition in the precuneus can lead to oxidative stress, neuroinflammation, and accelerated neurodegeneration. Metabolic disorders (diabetes, non‐alcoholic fatty liver disease (NAFLD), and obesity), genetic factors, and small vessel pathology contribute to abnormal iron accumulation in the precuneus. Therefore, in line with the growing body of literature in the precuneus region of patients with AD, QSM as a neuroimaging method could serve as a non‐invasive biomarker to track disease progression, complement other imaging modalities, and aid in early AD diagnosis and monitoring.

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Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease

Cited by 7 publications

References 43 publications

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics

Editorial: Effects of vascular function and aging on brain circulation and neurodegeneration

Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review

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