2023
DOI: 10.1038/s41398-023-02411-8
|View full text |Cite
|
Sign up to set email alerts
|

Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort

Abstract: Women carry a higher burden of Alzheimer’s disease (AD) compared to men, which is not accounted entirely by differences in lifespan. To identify the mechanisms underlying this effect, we investigated sex-specific differences in the progression of familial AD in humans and in APPswe/PS1ΔE9 mice. Activity dependent protein translation and associative learning and memory deficits were examined in APPswe/PS1ΔE9 mice and wild-type mice. As a human comparator group, progression of cognitive dysfunction was assessed … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
5
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 7 publications
(6 citation statements)
references
References 93 publications
1
5
0
Order By: Relevance
“…Sex is well established as one of the risk factors for AD pathology, with several studies demonstrating sex differences in AD ( 53 , 54 , 55 , 56 , 57 , 58 , 59 ). According to a previous report, male APP/PS1 mice showed memory recall deficits earlier than female APP/PS1 mice ( 4 , 58 ). We found the early dysregulation of Akt/mTOR signaling pathways in the synaptosomes isolated from the brain cortex of APP/PS1 mice ( 43 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Sex is well established as one of the risk factors for AD pathology, with several studies demonstrating sex differences in AD ( 53 , 54 , 55 , 56 , 57 , 58 , 59 ). According to a previous report, male APP/PS1 mice showed memory recall deficits earlier than female APP/PS1 mice ( 4 , 58 ). We found the early dysregulation of Akt/mTOR signaling pathways in the synaptosomes isolated from the brain cortex of APP/PS1 mice ( 43 ).…”
Section: Discussionmentioning
confidence: 99%
“…We therefore sought to elucidate the role of A-β in hippocampus dependent long-term memory and Akt/mTOR signaling pathways in male mice well before the manifestation of clinical symptoms. Female mice are demonstrated to exhibit greater resilience to early-stage pathological changes when compared to males ( 58 , 60 , 61 ). Because of sex hormones like estrogen, female mice, as long as their estrogen levels remain intact, are better protected than male mice ( 62 , 63 ).…”
Section: Discussionmentioning
confidence: 99%
“…Several epidemiological studies support the conclusion that women carry a higher burden of AD compared with men. This sex difference is not accounted entirely by differences in life span but involves biological mechanisms that are still incompletely understood (73,74). Although CRS can be easily applied to both males and females, female laboratory mice do not manifest despotic territorial behavior, and their aggression is significantly less than in males or wild female mice (75).…”
Section: Limitations Of the Study And Future Directionsmentioning
confidence: 99%
“…Women, who represent about two-thirds of AD patients, exhibit a faster cognitive decline and higher susceptibility to AD ( Hampel et al, 2018 ; Levine et al, 2021 ; Martinkova et al, 2021 ; Cui et al, 2023 ). This increased vulnerability is partly due to women’s longer average lifespan compared to men’s ( Hampel et al, 2018 ; Guo et al, 2022 ; Kommaddi et al, 2023 ). For instance, women outlive men by approximately 4.5 years globally, with a higher number of women reaching the age of 85 and beyond ( Zhu et al, 2021 ).…”
Section: Introductionmentioning
confidence: 99%
“…This longevity contributes to their amplified risk of developing AD with age. However, age alone does not fully explain the higher incidence and lifetime risk of AD in women ( Cui et al, 2023 ; Kommaddi et al, 2023 ). Therefore, exploring the genetics and mechanisms underlying sex differences in AD is crucial for developing sex-specific therapeutic strategies.…”
Section: Introductionmentioning
confidence: 99%