Sex difference in the effects of alcohol on gastric emptying in healthy volunteers:A study using the 13C breath test

Horikoshi, Miyuki; Funakoshi, Akihiro; Miyasaka, Kyoko; Sekime, Ayako

doi:10.2220/biomedres.34.275

Cited by 5 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…water, but the extent to which seems to be dependent on several different factors and e.g. gender (Horikoshi et al, 2013), alcohol concentration and type of alcohol containing beverage (Franke et al, 2004) that is ingested have been suggested to affect emptying rate. The complex interplay between alcohol containing beverages and gastric emptying rate made us decide to use the fasted state gastric emptying rate defined in the GISim during simulations.…”

Section: Discussionmentioning

confidence: 99%

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg

Sjögren

Bergström

2015

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Ethanol can increase the solubility of poorly soluble and hence present a higher drug concentration in the gastrointestinal tract. This may produce a faster and more effective absorption resulting in variable and/or high drug plasma concentrations, both of which can lead to adverse drug reactions. In this work we therefore studied the solubility and absorption effects of nine diverse compounds when ethanol was present. The apparent solubility was measured using the μDiss Profiler Plus (pION, MA) in four media representing gastric conditions with and without ethanol. The solubility results were combined with in-house data on solubility in intestinal fluids (with and without ethanol) and pharmacokinetic parameters extracted from the literature and used as input in compartmental absorption simulations using the software GI-Sim. Apparent solubility increased more than 7-fold for non-ionized compounds in simulated gastric fluid containing 20% ethanol. Compounds with weak base functions (cinnarizine, dipyridamole and terfenadine) were completely ionized at the studied gastric pH and their solubility was therefore unaffected by ethanol. Compounds with low solubility in intestinal media and a pronounced solubility increase due to ethanol in the upper gastric compartments showed an increased absorption in the simulations. The rate of absorption of the acidic compounds indomethacin and indoprofen was slightly increased but the extent of absorption was unaffected as the complete doses were readily absorbed even without ethanol. This was likely due to a high apparent solubility in the intestinal compartment where the weak acids are ionized. The absorption of the studied non-ionizable compounds increased when ethanol was present in the gastric and intestinal media. These results indicate that concomitant intake of alcohol may significantly increase the solubility and hence, the plasma concentration for non-ionizable, lipophilic compounds with the potential of adverse drug reactions to occur.

show abstract

Section: Discussionmentioning

confidence: 99%

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Fagerberg

Sjögren

Bergström

2015

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

Men and Women Differ in Gastric Fluid Retention and Neural Activation after Consumption of Carbonated Beverages

Camps

Graaf

Smeets

2018

The Journal of Nutrition

View full text Add to dashboard Cite

Background The most commonly consumed carbonated beverages are soda and beer. Carbon dioxide increases gastric volume, which can lead to epigastric discomfort. Women are more susceptible to this; however, correlations with neural activity and gastric distention are unknown. Objective This study sought to determine the subjective, gastric, and neural correlates of epigastric discomfort in men and women. Methods Thirty-four healthy, normal-weight adults [17 women; mean ± SD body mass index (BMI; kg/m2): 22.3 ± 1.9; 17 men; BMI: 22.8 ± 1.8] participated in a randomized crossover study with 2 treatments: ingestion of 500 mL beer or soda. Before and after consumption, gastric content and brain activity were measured with magnetic resonance imaging (MRI). Participants rated fullness, bloating, hunger, and nausea at baseline and at t = 0, 10, 20, and 30 min together with gastric MRI. Brain activity [cerebral blood flow (CBF)] was measured at baseline and at t = 5 and 35 min. Liquid, gas, and total gastric volume (TGV) were segmented from gastric MRI. Ratings and gastric content areas under the curve (AUCs) were tested with a mixed model with sex and drink as factors. Results For subjective ratings, only nausea in the beer condition scored significantly greater for women (9.4-point increase; P = 0.045). Liquid stomach content was significantly greater for women (2525 mL × min increase; P = 0.019). In both men and women, the strongest correlation for bloating was with TGV (r = 0.45, P < 0.01) and for nausea was with the liquid fraction AUC (r = 0.45, P < 0.01). CBF changes did not differ between the drinks. Men showed greater CBF than women in the left precentral and postcentral gyri at t = 5 min. Conclusions There are differences between sexes when it comes to appetite ratings, gastric fluid retention, and neural activation. Discomfort in women may be related to fluid rather than gas in the stomach, because they retain more fluid than men. Differences between men and women should be considered when studying digestion. This study was registered with the Dutch Trial Registry as NTR5418 (http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5418).

show abstract

<b>The menstrual cycle influences the gastric emptying of </b><b>alcohol </b>

et al. 2015

Self Cite

View full text Add to dashboard Cite

We previously reported that ingestion of 60 mL of red wine or vodka prior to the ingestion of a pancake significantly inhibited the gastric emptying of the pancake in male subjects, but not in female subjects, and that the retention times of wine and vodka were significantly longer than those of the congener of red wine and mineral water in male subjects, whereas in female subjects the retention times of these four drinks did not differ significantly from one another. We hypothesized that the menstrual cycle may influence the gastric emptying of alcohol beverages. Here, we determined and compared the retention times of vodka and water in the stomach during the luteal phase and the follicular phase. Ten female healthy volunteers were studied. They recorded their basal body temperatures every day, and participated in the following experiments: each volunteer drank mineral water or vodka containing 14% alcohol (60 mL) during the low-temperature (follicular) phase as well as during the high-temperature (luteal) phase. The retention time of vodka was significantly longer than that of mineral water during the follicular phase, but no significant differences between the retention times of the two drinks were observed during the luteal phase. In conclusion, the menstrual cycle influences the gastric emptying rate of alcohol.Several studies (8,9,13,15) showed that alcohol consumption delayed the gastric emptying of meals in healthy male subjects, but these studies did not examine female subjects. We (1) observed that the ingestion of 60 mL of red wine or vodka prior to a pancake meal, significantly inhibited the gastric emptying of the pancake in male subjects, but not in female subjects. We later determined the retention times of vodka, red wine, the congener (a non-alcoholic component) of red wine, and mineral water (all 60 mL) in the stomach, and we (24) found that the retention times of wine and vodka were significantly longer than those of the congener and mineral water in the male subjects, but the retention time of these four beverages did not differ significantly from one another in the female subjects. Regarding the reason(s) why the alcohol beverages did not have elongated retention times in the stomachs of female subjects as they did in males, we hypothesized that the menstrual cycle may influence the gastric emptying rate of alcohol beverages. Although several studies (4,6,12,14) have assessed the effect of the menstrual cycle on gastric emptying, the results are conflicting; moreover, the effects of alcohol beverages on gastric emptying were not examined in those studies. In the present study, we determined and compared the retention times of vodka and water in the stomach during the luteal phase and the follicular phase. MATERIALS AND METHODSThis human study was approved by the Ethics Committee of Tokyo Kasei University. All participants provided their written informed consent.

show abstract

Sex difference in the effects of alcohol on gastric emptying in healthy volunteers:A study using the 13C breath test

Cited by 5 publications

References 18 publications

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Concomitant intake of alcohol may increase the absorption of poorly soluble drugs

Men and Women Differ in Gastric Fluid Retention and Neural Activation after Consumption of Carbonated Beverages

<b>The menstrual cycle influences the gastric emptying of </b><b>alcohol </b>

Contact Info

Product

Resources

About