Sex difference in the morbidity and pain response with stage 0 of medication-related osteonecrosis of the jaws

Zhang, Weidong; Gao, Ruihan; Cui, Yaokui; Fan, Daiming; Zhu, Shuyu; Luo, Sheng-Kang; Liu, Hongrui; Li, Minqi

doi:10.1016/j.job.2023.07.001

Cited by 1 publication

(2 citation statements)

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“…A study found that using exposed necrotic bone as a diagnostic criterion did not reveal significant differences in MRONJ incidence between sexes [1]. However, it did report subdued pain responses in male mice compared to female mice in cases of stage 0 MRONJ diagnosed histologically in murine models, suggesting that males might experience under-diagnosis or delayed diagnosis due to less severe pain symptoms, potentially leading to later stage identification of MRONJ in this group [11].…”

Section: Incidence Associated With Age and Sexmentioning

confidence: 99%

“…These divergent findings underscore the complexity of the sex-MRONJ incidence relationship. The first study [11] highlights the risk of under-diagnosis in males due to less pronounced pain symptoms, whereas the second study [12] points to a potentially higher incidence of MRONJ in males, especially in particular areas of the jaw after surgical interventions. Both studies stress the necessity of acknowledging sex-based differences in the presentation, diagnosis, and progression of MRONJ.…”

Section: Incidence Associated With Age and Sexmentioning

confidence: 99%

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Unveiling Medication-Related Osteonecrosis of the Jaw: A Rapid Review of Etiology, Drug Holidays, and Treatment Strategies

Oh,

Kim

2024

Applied Sciences

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This rapid review critically evaluates recent advancements in the management of medication-related osteonecrosis of the jaw (MRONJ) from 2022 to 2023, employing a specific article selection protocol to focus on the latest literature. Initially screening 262 articles and ultimately selecting 22 based on their relevance and uniqueness, the process involved meticulous screening, methodological evaluation, and data extraction by the authors. The findings, organized into epidemiology, treatment effectiveness, and drug holidays, are synthesized following rapid review guidelines. The review addresses the risk of MRONJ associated with tooth extraction in patients undergoing antiresorptive medication therapy, such as bisphosphonates (BPs) and denosumab (DS), and evaluates the effectiveness of drug holidays in reducing this risk. Recent studies suggest that drug holidays may not effectively mitigate MRONJ risks as previously believed. Furthermore, it highlights that conservative treatment can benefit asymptomatic early-stage MRONJ patients, whereas surgical intervention is more effective for those in advanced stages. Ultimately, this review synthesizes current findings to enhance clinical practice, suggesting that while drug holidays may not significantly reduce MRONJ risks, treatment strategies should be tailored, ranging from conservative approaches in early stages to surgical interventions in advanced stages, thereby guiding evidence-based clinical decisions.

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Section: Incidence Associated With Age and Sexmentioning

confidence: 99%

Section: Incidence Associated With Age and Sexmentioning

confidence: 99%