Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging &amp; Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

Blanken, Machteld A.J.T.; Oudega, Mardien L.; Almeida, Osvaldo P.; Schouws, Sigfried N.T.M.; Orhan, Melis; Beunders, Alexandra J.M.; Klumpers, Ursula M.H.; Sonnenberg, Caroline; Blumberg, Hilary P.; Eyler, Lisa T.; Forester, Brent P.; Forlenza, Orestes V.; Gildengers, Ariel; Mulsant, Benoit H.; Rajji, Tarek; Rej, Soham; Sarna, Kaylee; Sutherland, Ashley; Yala, Joy; Vieta, Eduard; Tsai, Shangying; Briggs, Farren B.S.; Sajatovic, Martha; Dols, Annemiek

doi:10.1016/j.jagp.2023.10.008

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Some clinical manifestations are different between sexes in OABD, where females scored higher on anxiety and hypochondriasis, and had a higher number of hospitalizations. In contrast, males had more lifetime substance abuse disorders ( 77 ) suggesting the existence of different clinical and disease underlying mechanisms between the two sexes. Other potential confounding variables, in addition to age and sex, that will be considered in the analysis, could be pharmacological treatment, illness history, and educational attainment due to the association with cognitive performance, response to treatment, and brain functionality.…”

Section: Discussionmentioning

confidence: 98%

Study protocol – elucidating the neural correlates of functional remediation for older adults with bipolar disorder

Montejo,

Sole,

Fortea

et al. 2024

Front. Psychiatry

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IntroductionBeyond mood abnormalities, bipolar disorder (BD) includes cognitive impairments that worsen psychosocial functioning and quality of life. These deficits are especially severe in older adults with BD (OABD), a condition expected to represent most individuals with BD in the upcoming years. Restoring the psychosocial functioning of this population will thus soon represent a public health priority. To help tackle the problem, the Bipolar and Depressive Disorders Unit at the Hospital Clínic of Barcelona has recently adapted its Functional Remediation (FR) program to that population, calling it FROA-BD. However, while scarce previous studies localize the neural mechanisms of cognitive remediation interventions in the dorsal prefrontal cortex, the specific mechanisms are seldom unknown. In the present project, we will investigate the neural correlates of FR-OABD to understand its mechanisms better and inform for potential optimization. The aim is to investigate the brain features and changes associated with FROA-BD efficacy.MethodsThirty-two individuals with OABD in full or partial remission will undergo a magnetic resonance imaging (MRI) session before receiving FR-OABD. After completing the FR-OABD intervention, they will undergo another MRI session. The MRI sessions will include structural, diffusion-weighted imaging (DWI), functional MRI (fMRI) with working memory (n-back) and verbal learning tasks, and frontal spectroscopy. We will correlate the pre-post change in dorsolateral and dorsomedial prefrontal cortices activation during the n-back task with the change in psychosocial functioning [measured with the Functioning Assessment Short Test (FAST)]. We will also conduct exploratory whole-brain correlation analyses between baseline or pre-post changes in MRI data and other clinical and cognitive outcomes to provide more insights into the mechanisms and explore potential brain markers that may predict a better treatment response. We will also conduct separate analyses by sex.DiscussionThe results of this study may provide insights into how FROA-BD and other cognitive remediations modulate brain function and thus could optimize these interventions.

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Section: Discussionmentioning

confidence: 98%

Study protocol – elucidating the neural correlates of functional remediation for older adults with bipolar disorder

Montejo,

Sole,

Fortea

et al. 2024

Front. Psychiatry

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Quality of life in older adults with mood states associated with bipolar disorder: A secondary analysis of the English longitudinal study of ageing data

Warner,

Holland,

Lobban

et al. 2024

British J Clinic Psychol

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ObjectivesTo investigate: (i) whether mood states associated with bipolar disorder are associated with poorer quality of life in older adults, and (ii) what are some of the predictors of quality of life in older adults with mood states associated with bipolar disorder.MethodsThe authors completed a cross‐sectional multilevel analysis of panel data from seven waves of The English Longitudinal Study of Ageing dataset. The main analysis included 567 participants who reported experiencing mood states associated with bipolar disorder. Some participants reported this in more than one wave, resulting in 835 observations of mood states associated with bipolar disorder across the seven waves. Quality of life was assessed using the Control, Autonomy, Self‐realization, and Pleasure‐19 (CASP‐19) measure.ResultsThe presence of mood states associated with bipolar disorder was significantly associated with poorer quality of life, even after controlling for multiple covariates (age, sex, social isolation, loneliness, alcohol use, education level, and economic status). Loneliness significantly predicted poorer quality of life in older adults with mood states associated with bipolar disorder. In contrast, higher educational attainment and being female predicted better quality of life in this group.ConclusionsOlder adults with mood states associated with bipolar disorder have potentially worse quality of life compared to the general population, which may be partly driven by loneliness. This has ramifications for the support offered to this population and suggests that treatments should focus on reducing loneliness to improve outcomes.

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Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

Cited by 2 publications

References 37 publications

Study protocol – elucidating the neural correlates of functional remediation for older adults with bipolar disorder

Study protocol – elucidating the neural correlates of functional remediation for older adults with bipolar disorder

Quality of life in older adults with mood states associated with bipolar disorder: A secondary analysis of the English longitudinal study of ageing data

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