Sex differences in angiotensin II‐stimulated fluid intake

Santollo, Jessica

doi:10.1113/ep086518

Cited by 13 publications

(6 citation statements)

References 32 publications

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“…Examination of sex differences in body fluid homeostasis are also in progress. Recent studies have revealed an effect of sex on thirst, including increased water intake in male rats compared to female rats in response to angiotensin II ( 248 ), a lack of desensitization to repeated angiotensin II administration in female rats ( 249 ), and interactions of thirst and estrogens ( 250 ). Thus, future work should examine whether these sex dimorphisms in homeostatic regulation are reflected in mesolimbic phasic dopamine signaling.…”

Section: Conclusion and Considerationsmentioning

confidence: 99%

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

2018

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Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumption, in turn, reinforces motivated behavior and is therefore considered rewarding. Over the years, the constructs of homeostatic (within the purview of the hypothalamus) and reward (within the purview of mesolimbic circuitry) have been used to describe need-based vs. need-free consumption. However, many experiments have demonstrated that mesolimbic circuits and “higher-order” brain regions are also profoundly influenced by changes to physiological state, which in turn generate behaviors that are poised to maintain homeostasis. Mesolimbic pathways, particularly dopamine neurons of the ventral tegmental area (VTA) and their projections to nucleus accumbens (NAc), can be robustly modulated by a variety of energy balance signals, including post-ingestive feedback relaying nutrient content and hormonal signals reflecting hunger and satiety. Moreover, physiological states can also impact VTA-NAc responses to non-nutritive rewards, such as drugs of abuse. Coupled with recent evidence showing hypothalamic structures are modulated in anticipation of replenished need, classic boundaries between circuits that convey perturbations in homeostasis and those that drive motivated behavior are being questioned. In the current review, we examine data that have revealed the importance of mesolimbic dopamine neurons and their downstream pathways as a dynamic neurobiological mechanism that provides an interface between physiological state, perturbations to homeostasis, and reward-seeking behaviors.

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Section: Conclusion and Considerationsmentioning

confidence: 99%

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

2018

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“…Differences in hormone levels may be one of the potential explanations. Angiotensin II (Ang II), a key component of the renin-angiotensin–aldosterone system to maintain proper fluid homeostasis, could increase water intake and is associated with drinking microstructure, and both ovarian and testicular hormones contribute to sex differences in the water intake response to Ang II ( 32 ). Under modulation of different hormones, adult females preferred saline intake over adult males ( 33 ), and salt intake was also associated with mortality risk.…”

Section: Discussionmentioning

confidence: 99%

Association Between Water Intake and Mortality Risk—Evidence From a National Prospective Study

et al. 2022

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BackgroundFew studies have explored the association between water intake and mortality risk, and the findings were inconsistent.ObjectiveThis study aimed to explore the water intake–mortality association, utilizing the data from the National Health and Nutrition Examination Survey (NHANES) and the 2015 public-linked mortality files released by the National Center for Health Statistics.MethodsWe used the diet- and mortality-linked data of a total of 35,463 adults (17,234 men) aged ≥20 years in the NHANESs 1999–2014 to perform a prospective study. The multivariate-adjusted Cox proportional hazards model was used to explore the associations of the amount of water intake (expressed by total water, plain water, beverage, and food water) and water intake proportion (expressed by the percentage of each kind of water) with mortality risks due to all causes, malignant neoplasms/cancer, and heart disease. The restricted cubic spline plots were adopted to clarify the dose–response relationships among them.ResultsWith a median of 88 months (interquartile range: 49–136 months) follow-up, a total of 4,915 all-cause deaths occurred, including 1,073 and 861 deaths from malignant neoplasms/cancer and heart disease, respectively. The amount of water intake in either type was negatively associated with all-cause mortality risk. Additionally, the negative linear dose–response relationships of water intake and all-cause mortality risk were found for all types of water except for food water, which followed a non-linear pattern. Similarly, compared to the lowest quartile (beverage water intake: <676 g/day; food water intake: <532 g/day), beverage and food water intakes in the range of 1,033–1,524 and 1,612–3,802 g/day were associated with decreased malignant neoplasms/cancer mortality risk. A U-shaped dose–response relationship was found for beverage water intake and malignant neoplasms/cancer mortality risk and a negative linear dose–response relationship was found for food water intake and malignant neoplasms/cancer mortality risk. Coffee and/or tea consumption was/were negatively associated with mortality risks due to all causes and malignant neoplasms/cancer. No significant associations of water intake proportion and mortality risks were found.ConclusionOur findings demonstrated that higher water intake is associated with lower mortality risks among the United States population.

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“…Although our findings also suggest a sex difference in the effects of seaweed intake on blood pressure, the mechanisms are unknown. As the release of vasopressin and aldosterone induced by angiotensin II and the fluid intake response to angiotensin II were reported to differ by sex, 37 the effect of nori-derived peptides on the renin-angiotensinaldosterone system may also be influenced by sex.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Nori (Dried Laver) on Blood Pressure in Young Japanese Children: An Intervention Study

Wada

Tsuji

Nakamura

et al. 2021

Journal of Epidemiology

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Background: Few studies have examined the association between seaweed intake and blood pressure in children. We conducted an intervention study to investigate whether seaweed intake affects blood pressure. Methods: Subjects were children aged 4 to 5 years attending a preschool in Aichi Prefecture, Japan, in 2010. Among 99 students, 89 (89.9%) were enrolled in our study. Nori (dried laver), an edible seaweed widely consumed in Japan, was used as a dietary intervention. Children in the intervention group were asked to consume 1.76 grams per day of roasted nori in addition to standard meals for 10 weeks. Children in the control group consumed their usual diet. Before the intervention and at the 10th week of the intervention, children's blood pressure was measured three times successively using an automated sphygmomanometer with subjects in a sitting position. Changes in systolic (SBP) and diastolic blood pressure (DBP) were compared between 55 children in the intervention group and 26 in the control group after adjustment for SBP and DBP before the intervention. Results: Changes in SBP were −8.29 mm Hg in the intervention group and +0.50 mm Hg in the control group (P for difference in change = 0.051). Changes in DBP were −6.77 mm Hg in the intervention group and −0.05 mm Hg in the control group (P = 0.031). In girls, no difference in blood pressure changes was found between the intervention and control groups. Conclusion: Nori intake lowered DBP level in boys. Seaweed intake might have preventive effects on elevated blood pressure in childhood.

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Sex differences in angiotensin II‐stimulated fluid intake

Cited by 13 publications

References 32 publications

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

Association Between Water Intake and Mortality Risk—Evidence From a National Prospective Study

Effect of Dietary Nori (Dried Laver) on Blood Pressure in Young Japanese Children: An Intervention Study

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