Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline

Swalve, Natashia; Smethells, John R.; Carroll, Marilyn E.

doi:10.1016/j.bbr.2016.04.023

Cited by 21 publications

(14 citation statements)

References 72 publications

(106 reference statements)

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“…Sex differences are observed during all stages of nicotine addiction, from initiation to dependence, withdrawal, and relapse. The current Review evaluates sex differences observed in nicotine preference during exposure to nicotine, notwithstanding the fact that important sex differences have been reported during extinction or reinstatement of nicotine‐seeking (Feltenstein et al, ; Swalve et al, ). In laboratory animals, the methods used for evaluating individual differences in nicotine preference involve “asking” male and female animals if they like nicotine or not.…”

Section: Comparison Of the Three Animal Models Used To Study Nicotinementioning

confidence: 99%

Sex differences in nicotine preference

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et al. 2016

J of Neuroscience Research

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Smoking is the major cause of preventable deaths worldwide, and although there is a decline in overall smoking prevalence in developed countries, the decline in women is less pronounced than in men. Women become dependent faster and experience greater difficulties in quitting. Similar trends have been observed in animal models of nicotine/tobacco addiction. Individual differences in vulnerability to drug abuse are also observed in nicotine/ tobacco addiction and point to the importance of sex differences. This Review, summarizes findings from three experimental approaches used to depict nicotine preference in animal models, intravenous and oral nicotine selfadministration and nicotine-induced conditioned place preference. Nicotine preference is considered to be reflected in the animal's motivation to administer the drug (intravenously or orally) or to prefer an environment paired with the presence of the drug (conditioned place preference). These approaches all point to the importance of sex and age of the subjects; the preference of females and adolescents appear to be more pronounced than that of males and adults, respectively. A closer look at these factors will help us understand the mechanisms that underlie nicotine addiction and develop strategies to cope. Ignoring sex differences and reaching conclusions based only on studies using male subjects has resulted in erroneous generalizations in the past. Sex differences in nicotine preference have been clearly documented, and awareness on this aspect of nicotine dependence will significantly impact our success in translational research. V C 2016 Wiley Periodicals, Inc.

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Section: Comparison Of the Three Animal Models Used To Study Nicotinementioning

confidence: 99%

Sex differences in nicotine preference

Pöğün

Yararbaş

Nesil

et al. 2016

J of Neuroscience Research

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“…This suggests that relatively low doses of nAChR antagonists could be used to diminish cue-induced craving and prevent relapse in smokers. The smoking cessation drug varenicline inhibits reinstatement of operant responding induced by nicotine-prime and a combination of nicotine-prime and cues (O’Connor et al 2010; Swalve et al 2016). In contrast, bupropion potentiates cue-induced reinstatement of nicotine seeking (Liu et al 2008).…”

Section: Reinstatement Of Nicotine Seekingmentioning

confidence: 99%

Neuropeptide systems and new treatments for nicotine addiction

Bruijnzeel

2016

Psychopharmacology

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RATIONALE The mildly euphoric and cognitive enhancing effects of nicotine play a role in the initiation of smoking, while dysphoria and anxiety associated with smoking cessation contribute to relapse. After the acute withdrawal phase, smoking cues, a few cigarettes (i.e., lapse), and stressors can cause relapse. Human and animal studies have shown that neuropeptides play a critical role in nicotine addiction. OBJECTIVES The goal of this paper is to describe the role of neuropeptide systems in the initiation of nicotine intake, nicotine withdrawal, and the reinstatement of extinguished nicotine seeking. RESULTS The reviewed studies indicate that several drugs that target neuropeptide systems diminish the rewarding effects of nicotine by preventing the activation of dopaminergic systems. Other peptide-based drugs diminish the hyperactivity of brain stress systems and diminish withdrawal-associated symptom severity. Blockade of hypocretin-1 and nociceptin receptors and stimulation of galanin and neurotensin receptors diminishes the rewarding effects of nicotine. Both corticotropin-releasing factor type 1 and kappa-opioid receptor antagonists diminish dysphoria and anxiety-like behavior associated with nicotine withdrawal and inhibit stress-induced reinstatement of nicotine seeking. Furthermore, blockade of vasopressin 1b receptors diminishes dysphoria during nicotine withdrawal and melanocortin 4 receptor blockade prevents stress-induced reinstatement of nicotine seeking. The role of neuropeptide systems in nicotine-primed and cue-induced reinstatement is largely unexplored, but there is evidence for a role of hypocretin-1 receptors in cue-induced reinstatement of nicotine seeking. CONCLUSION Drugs that target neuropeptide systems might decrease the euphoric effects of smoking and improve relapse rates by diminishing withdrawal symptoms and improving stress resilience.

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“…Progesterone (PRO; Sigma Aldrich, St. Louis, MO) was dissolved in peanut oil (VEH; Sigma Aldrich) to a final dose of 0.5 mg/kg administered subcutaneously 30 minutes prior to experimental sessions. This dose has produced endogenously relevant levels of PRO (Jackson et al 2006), and it decreased cocaine-seeking and impulsivity for food and cocaine in our previous studies (see Anker et al 2011 for a review; Smethells et al 2016; Swalve et al 2016a, b, d; Zlebnik et al 2014). …”

Section: Methodsmentioning

confidence: 86%

“…In most animal studies, females exceed males on acquisition (Lynch and Carroll 1999; Jackson et al 2006; Lynch 2009; but see Caine et al 2004; Swalve et al 2016b; for review see Anker and Carroll 2011) and maintenance of cocaine self-administration (Lynch and Carroll 1999; Anker et al 2011; Cummings et al 2011; Peterson et al 2014; Swalve et al 2016c; but see Roberts et al 1989; Cosgrove et al 2002; Jackson et al 2006; Kosten and Zhang 2008; Perry et al 2013). Animal studies also indicate that females have a better response to PRO treatment for cocaine self-administration than males (Carroll and Lynch 2016; Carroll and Smethells 2016).…”

Section: Introductionmentioning

confidence: 99%

Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats

et al. 2017

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Rationale Previous work indicated that progesterone (PRO) reduced impulsive choice for cocaine in female but not male rats (Smethells et al. 2016). Impulsive action, typically measured by responding for a reinforcer during a signaled period of nonavailability of natural reinforcers, predicts initiation and escalation of drug use in animals and humans. The present study examined impulsive action for cocaine using progesterone (PRO) in male and female rats trained on a Go/No-go task. Objective Rats were trained on a Go/No-go task to respond for cocaine infusions (0.4 mg/kg/inf). During the “Go” component, responding was reinforced on a VI 30-s schedule; whereas, during the “No-Go” component withholding a response was reinforced on a differential reinforcement of other behavior (DRO) 30-s schedule. A response during the No-go component reset the DRO timer and served as a measure of impulsive action. After baseline responding was established, rats were pretreated with vehicle (VEH) or PRO (0.5 mg/kg), and DRO resets and responding during the Go component for cocaine were compared in males vs. females. Results DRO resets were significantly lower following PRO treatment compared to VEH in female, but not male, rats. Response rates and overall infusions during the Go component were not significantly altered by PRO in either females or males. Conclusion Treatment with PRO resulted in a sex-specific reduction in impulsive action for cocaine, while not affecting cocaine self-administration.

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Sex differences in attenuation of nicotine reinstatement after individual and combined treatments of progesterone and varenicline

Cited by 21 publications

References 72 publications

Sex differences in nicotine preference

Sex differences in nicotine preference

Neuropeptide systems and new treatments for nicotine addiction

Sex-specific attenuation of impulsive action by progesterone in a go/no-go task for cocaine in rats

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