Sex differences in behavioral taste responses to and ingestion of sucrose and NaCl solutions by rats

Curtis, Kathleen S.; Davis, Linda M.; Johnson, A. G.; Therrien, Kelly L; Contreras, Robert J.

doi:10.1016/j.physbeh.2003.11.007

Cited by 77 publications

(70 citation statements)

References 24 publications

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“…An elegant apparatus for briefaccess tests offers animals repeated 10-s exposures to as many as eight different test fluids in random order in the same session, so that the postoropharyngeal food stimuli that develop during the session do not differ for the different test fluids (680). Using this method, Curtis et al (152) found that 1) male rats licked approximately twofold more 0.025 or 0.05 M sucrose than did females, 2) males and females licked similarly during exposure to 0.1-0.4 M sucrose (Fig. 15A) and …”

Section: Melanocyte-stimulating Hormones and Melanocortinmentioning

confidence: 99%

“…*Significantly different from both groups of ovariectomized females. A and B: Reprinted from Physiology and Behavior, Sex differences in behavioral taste responses to and ingestion of sucrose and NaCl solutions by rats, Kathleen S. Curtis, Linda M. Davis, Amy L. Johnson, Kelly L. Therrien, Robert J. Contreras, 80: 657-664, 2004; republished with permission from Elsevier; from Curtis et al (152). C: intact rats tested during estrus (E/SAL, triangles) licked less 0.025 M sucrose solutions in 10-s palatability tests than rats tested during diestrus 2 (D2/SAL, circles).…”

Section: R1240 Sex Differences In the Physiology Of Eatingmentioning

confidence: 99%

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Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

414

349

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(HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. These controls result from interactions among genetic effects, organizational effects of reproductive hormones (i.e., permanent early developmental effects), and activational effects of these hormones (i.e., effects dependent on hormone levels). Male-female sex differences in the physiology of eating involve both organizational and activational effects of androgens and estrogens. An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence or ovariectomy in rats and monkeys, sometimes in mice, and possibly in women. Estrogens acting on estrogen receptor-␣ (ER␣) in the caudal medial nucleus of the solitary tract appear to mediate these effects in rats. Androgens, prolactin, and other reproductive hormones also affect eating in rats. Sex differences in eating are mediated by alterations in orosensory capacity and hedonics, gastric mechanoreception, ghrelin, CCK, glucagon-like peptide-1 (GLP-1), glucagon, insulin, amylin, apolipoprotein A-IV, fatty-acid oxidation, and leptin. The control of eating by central neurochemical signaling via serotonin, MSH, neuropeptide Y, Agouti-related peptide (AgRP), melanin-concentrating hormone, and dopamine is modulated by HPG function. Finally, sex differences in the physiology of eating may contribute to human obesity, anorexia nervosa, and binge eating. The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.neuroendocrinology; estrogens; testosterone; eating disorders; obesity SEX DIFFERENCES ARE PERVASIVE in physiology and medicine (51,64,73,109,110,466,797,826). The controls of eating and energy homeostasis are no exceptions. It was observed approximately 100 years ago that removal of the ovaries leads to marked accretion of adipose tissue in rats (697), that daily food intake expressed as kilocalories per gram body weight differs between male and female rats (778), and that food intake varies regularly through the ovarian cycle in intact female rats (674, 779). Sex differences in eating have been the subject of physiological research ever since. The clinical relevance of this work is increasingly evident. In the United States, women are approximately threefold more vulnerable than men to psychiatric eating disorders (346,351) and approximately twofold more vulnerable to severe and morbid obesity (BMI Ն 35 and 40 kg/m 2 , respectively, mass/height 2 ) (226). Women also appear to suffer more from these disorders in terms of physical and psychological functioning and quality of life (24,84,273,292,465,531,762). The increased obesity burden suffered by women is reflected in the fact that Ͼ80% of bariatric surgery patients in the U...

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Section: Melanocyte-stimulating Hormones and Melanocortinmentioning

confidence: 99%

Section: R1240 Sex Differences In the Physiology Of Eatingmentioning

confidence: 99%

Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

414

349

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“…Although investigations of sex differences in taste responses span four decades and have examined taste stimuli from sweet to salt to bitter (4,5,8,9,11,13,14,35,51,58,59), little work has focused on the mechanisms that underlie such differences. Certainly, this is true of sex differences in the taste of MSG and of FFAs such as LA, taste stimuli that have received much less attention.…”

Section: Perspectivesmentioning

confidence: 99%

Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats

Stratford

Curtis²,

Contreras³

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Previous studies suggest that the chorda tympani nerve (CT) is important in transmitting fat taste information to the central nervous system. However, the contribution of the CT in this process may depend upon the presence of other taste stimuli and/or differ in males and females. Accordingly, the present study investigated the role of the CT in free fatty acid taste processing by examining electrophysiological activity of the CT in response to the free fatty acid linoleic acid (LA), as well as by measuring behavioral responses to LA-taste mixtures. We recorded whole nerve responses from the CT in response to lingual application of LA with or without monosodium glutamate (MSG) in anesthetized male and female rats. In addition, we examined preferences for MSG + LA taste mixtures in behavioral tests. Although lingual application of LA alone did not produce CT whole nerve responses, coapplication of LA and MSG elicited greater CT responses than did MSG alone. These findings were paralleled by greater preferences for MSG + LA taste mixtures than for MSG alone. In both cases, the effect was particularly pronounced in male rats. Thus LA enhances CT activity and behavioral responses to LA + MSG taste mixtures, although there are sex differences in the effects. These results suggest that CT input is important in mediating behavioral responses to fat taste, but the effects depend upon other taste stimuli and differ in males and females.

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“…First, no experiment examining the effects of enrichment on body weight has directly compared male and female subjects. Males and females differ in their biology and react differently to environmental conditions (e.g., Cortright et al, 1997;Kolb et al, 1998;Curtis et al, 2004 A third limitation of environmental research on body weight is that the feeding behavior of adolescent animals reared in environmental enrichment has not been reported. The only investigation that reported the effects of environmental enrichment on food consumption used adult subjects (Sclafani & Springer, 1976).…”

Section: Limitations In the Literaturementioning

confidence: 99%

“…Males and females differ in their biology and they react differently to environmental conditions (e.g., Cortright, Chandler, Lemon, Lemon, & DiCarlo, 1997;Kolb, Forgie, & Gibb et al, 1998;Curtis et al, 2004). In humans, adult males have been reported to experience significant weight loss with exercise despite only mild energy deficits (Anderson et al, 1991).…”

Section: Sexmentioning

confidence: 99%

The Effects of Environmental Conditions on Activity, Feeding, and Body Weight in Male and Female Adolescent Rats

Tomchesson¹

2006

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Sex differences in behavioral taste responses to and ingestion of sucrose and NaCl solutions by rats

Cited by 77 publications

References 24 publications

Sex differences in the physiology of eating

Sex differences in the physiology of eating

Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats

The Effects of Environmental Conditions on Activity, Feeding, and Body Weight in Male and Female Adolescent Rats

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