2013
DOI: 10.1152/ajpheart.00391.2012
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Sex differences in blood pressure control during 6° head-down tilt bed rest

Abstract: Spaceflight-induced orthostatic intolerance has been studied for decades. Although ∼22% of the astronaut corps are women, most mechanistic studies use mostly male subjects, despite known sex differences in autonomic control and postflight orthostatic intolerance. We studied adrenergic, baroreflex, and autonomic indexes during continuous infusions of vasoactive drugs in men and women during a 60-day head-down bed rest. Volunteers were tested before bed rest (20 men and 10 women) and around day 30 (20 men and 10… Show more

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Cited by 21 publications
(21 citation statements)
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“…Experimental objectives were 1) to quantify the functional recruitment of Ah-type barosensory afferent fibers in the left ADN and 2) to determine what, if any, impact this additional pathway of myelinated barosensory afferents may have upon the frequency-dependent integration of the BRx. Collectively, our results support the hypothesis that low-threshold myelinated Ah-type aortic BR afferents substantially enhance the initial depressor response of the BRx in female compared with male rats and that these functional differences may account for, at least in part, the enhanced parasympathetic control of BP in females (3,44).…”
supporting
confidence: 83%
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“…Experimental objectives were 1) to quantify the functional recruitment of Ah-type barosensory afferent fibers in the left ADN and 2) to determine what, if any, impact this additional pathway of myelinated barosensory afferents may have upon the frequency-dependent integration of the BRx. Collectively, our results support the hypothesis that low-threshold myelinated Ah-type aortic BR afferents substantially enhance the initial depressor response of the BRx in female compared with male rats and that these functional differences may account for, at least in part, the enhanced parasympathetic control of BP in females (3,44).…”
supporting
confidence: 83%
“…Differences in body size and contributing factors such as sex hormones and genetics do not explain the sex bias observed in OH between the sexes (12,30). Because orthostatic BP regulation in women occurs via parasympathetic withdrawal more than sympathetic activation (3,34), a BR-mediated increase in tonic resting parasympathetic activity could result in women requiring a larger increase in HR compared with men to achieve orthostatic stabilization.…”
Section: Discussionmentioning
confidence: 95%
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“…Furthermore, applying different loading forces could reveal potential intensity-driven modulations. While previous experiments have already considered some of these aspects in orthostatic conditions [40,47,4,9,2], the results may not directly translate to HDT as this condition is characterized by increased central blood volume and reduced venous pooling when compared to upright posture.…”
Section: Discussionmentioning
confidence: 93%
“…The worldwide prevalence of hypertension between 2000 and 2025 was predicted to increase by 9% in males and 13% in females 2. In many low-income and middle-income countries, hypertension has been considered a major public health concern.…”
Section: Introductionmentioning
confidence: 99%