Sex Differences in Cardiometabolic Risk Factors among Hispanic/Latino Youth

Isasi, Carmen R.; Parrinello, Christina M.; Ayala, Guadalupe X.; Delamater, Alan M.; Perreira, Krista M.; Daviglus, Martha L.; Elder, John P.; Marchante, Ashley N.; Bangdiwala, Shrikant I.; Horn, Linda Van; Carnethon, Mercedes R.

doi:10.1016/j.jpeds.2016.05.037

Cited by 59 publications

(56 citation statements)

References 37 publications

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“…This pediatric population also has a high prevalence of early onset health risk factors, which may be attenuated by participating in muscular strength and endurance exercise (Cruz and Goran, 2004, Isasi et al, 2016). It is important to get a clearer understanding on the relationship between muscular strength and endurance and cardio-metabolic health in this pediatric population.…”

Section: Introductionmentioning

confidence: 99%

Muscular strength and endurance and cardio-metabolic health in disadvantaged Hispanic children from the U.S.

Burns

Brusseau

2017

Preventive Medicine Reports

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The predictive relationship between muscular strength and endurance and cardio-metabolic health, independent from aerobic fitness, is not clear in disadvantaged Hispanic children. The purpose of this study was to examine the predictive relationship between muscular strength and endurance and clustered cardio-metabolic risk, controlling for aerobic fitness, in Hispanic children from low-income schools. Participants were 320 Hispanic children (Mean age = 10.1 ± 1.1 years; 164 girls, 156 boys) recruited during the 2014–2015 and 2015–2016 academic years from five low-income schools from the state of Utah in the U.S. Muscular strength and endurance was assessed using the push-up and curl-up tests and estimated VO2 Peak was calculated from the Progressive Aerobic Cardiovascular Endurance Run. A clustered metabolic syndrome composite score (MetS) was calculated from cardio-metabolic health measurements consisting of HDL cholesterol, triglycerides, waist circumference, blood glucose, and mean arterial pressure (MAP). Multi-level general linear mixed effects models were used to examine the predictive relationship between muscular strength and endurance and MetS, controlling for the effect of aerobic fitness and the clustering of children within classrooms and schools. Children who were in the middle and upper tertiles for muscular strength and endurance associated with a lower (more favorable) MetS score (middle tertile: β = − 2.59, 95% C.I. [− 4.23, − 0.95], p < 0.05; upper tertile: β = − 1.57, 95% C.I. [− 3.20, − 0.16], p < 0.05). The results suggest that higher levels of muscular strength and endurance relate to lower cardio-metabolic risk, independent of aerobic fitness, in Hispanic children from low-income schools.

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Section: Introductionmentioning

confidence: 99%

Muscular strength and endurance and cardio-metabolic health in disadvantaged Hispanic children from the U.S.

Burns

Brusseau

2017

Preventive Medicine Reports

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“…1 In the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Youth (ie, “SOL Youth”), 2,3 26.5% and 19.9% of youth aged 8 to 16 were obese and overweight, respectively. 4 Whereas increasing physical activity and limiting sedentary time may prevent obesity and future health problems, 5–7 few children and adolescents meet 2008 US Department of Health and Human Services recommendations for activity levels of at least 60 minutes of moderate-to-vigorous physical activity (MVPA) daily 8 or screen time limits of no more than 2 hours daily. 9 …”

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confidence: 99%

Youth and Caregiver Physical Activity and Sedentary Time: HCHS/SOL Youth

et al. 2017

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Objectives We examined associations between youth and caregiver moderate/vigorous physical activity (MVPA) and sedentary (SED) time, using accelerometery, in the Hispanic Community Health Study/Study of Latino Youth (HCHS/SOL) Youth. Methods Participants were 623 caregivers and 877 youth 8–16 years old, enrolled in 2012–2014. Associations of youth and caregiver MVPA time, SED time, and meeting MVPA recommendations (> 150 min/week, adults; > 420 min/week, youth) were examined in regression models that controlled for sample weights, design effects, and demographic and health covariates. Results Youth whose caregivers met MVPA recommendations were nearly twice as likely to meet these recommendations themselves when compared to youth whose caregivers did not meet MVPA recommendations (OR = 1.9, 95% CI 1.1, 3.3). Youth and caregiver SED time also were significantly related (p < .05). A similar pattern of findings was observed in analyses limited to relationships in which the caregiver was a biological parent of the youth (N = 485 caregivers; N = 795 youth). Conclusions MVPA and SED are correlated within Latino families as observed by statistically significant relationships of youth and caregiver activity. Additional research is needed to understand underlying genetic and environmental factors that explain these findings.

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“…We have previously reported in this cohort that compared to girls, boys had a more adverse cardiometabolic risk profile, including higher prevalence of obesity and pre-diabetes (Isasi et al, 2016). However, others have reported that girls were more likely to exhibit insulin resistance than boys (Moran et al, 1999; Tester, Sharma, Jasik, Mietus-Snyder, & Tinajero-Deck, 2013).…”

Section: Discussionmentioning

confidence: 79%

Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

Parrinello

Hua

Carnethon

et al. 2017

Journal of Diabetes and its Complications

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Aims: We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. Methods: Among 1,316 children 8–16 years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional association of quartiles of fasting glucose, HbA1c, and insulin resistance with E-selectin and plasminogen activator inhibitor-1 (PAI-1) levels above the median (≥48.1 and ≥2.02 ng/mL, respectively). Results: Levels of E-selectin and PAI-1 were higher in children who were obese or had higher levels of hs-CRP (p <0.05). Insulin resistance was independently associated with higher levels of PAI-1 (adjusted PR and 95% CI for the highest versus lowest quartile (Q4 vs Q1): 2.25 [1.64, 3.09] ). We found stronger evidence of associations of insulin resistance with higher levels of PAI-1 among boys as compared with girls (p-interaction = 0.10). Conclusions: Insulin resistance was associated with endothelial dysfunction, as measured by higher levels of PAI-1, in Hispanic/Latino youth. These biomarkers may be useful in risk stratification and prediction of diabetes and cardiovascular disease in high-risk youth.

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Sex Differences in Cardiometabolic Risk Factors among Hispanic/Latino Youth

Cited by 59 publications

References 37 publications

Muscular strength and endurance and cardio-metabolic health in disadvantaged Hispanic children from the U.S.

Muscular strength and endurance and cardio-metabolic health in disadvantaged Hispanic children from the U.S.

Youth and Caregiver Physical Activity and Sedentary Time: HCHS/SOL Youth

Associations of hyperglycemia and insulin resistance with biomarkers of endothelial dysfunction in Hispanic/Latino youths: Results from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth)

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