Sex Differences in Drug Evaluations

Horrom, N J; Brown, Clinton C.

doi:10.1002/jps.2600660537

Cited by 4 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Performance of the auditory vigilance test (Wilkinson, 1968) was again improved by dexamphetamine and impaired by amitriptyline as previously reported (Bye, Munro-Faure, Peck & Young, 1973;Bye, Clubley & Peck, 1978). The increase in false reports by the women after dexamphetamine 10 mg compared with amitriptyline (and bupropion 50 mg) with no differences in men was interesting following recently reported sex differences in response to dexamphetamine and fenfluramine (Horrom & Brown, 1977). Reaction time, short term memory and tapping were impaired by amitriptyline as previously reported by the authors.…”

Section: Discussionsupporting

confidence: 76%

“…The increase in false reports by the women after dexamphetamine 10 mg compared with amitriptyline (and bupropion 50 mg) with no differences in men was interesting following recently reported sex differences in response to dexamphetamine and fenfluramine (Horrom & Brown, 1977). Reaction time, short term memory and tapping were impaired by amitriptyline as previously reported by the authors.…”

Section: Subjective Effectssupporting

confidence: 64%

See 1 more Smart Citation

A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects.

Peck¹,

Bye²,

Clubley³

et al. 1979

Brit J Clinical Pharma

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 76%

Section: Subjective Effectssupporting

confidence: 64%

A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects.

Peck¹,

Bye²,

Clubley³

et al. 1979

Brit J Clinical Pharma

View full text Add to dashboard Cite

Individual differences in the discriminative stimulus effects of d‐amphetamine in humans

Chait

Uhlenhuth

Johnson

1989

Drug Development Research

View full text Add to dashboard Cite

The discriminative stimulus (DS) and subjective effects of d-amphetamine (AMP) were examined in male and female normal healthy adults. Subjects were trained to discriminate between oral AMP (10 mg) and placebo. Of the 100 subjects who underwent discrimination training, 53 reliably learned the discrimination. These "discriminators" (Ds) were compared with the 47 "nondiscriminators" (NDs) on a variety of measures. Ds and NDs did not differ qualitatively in their response to AMP. As a group Ds were more certain than NDs of their ability to discriminate between AMP and placebo and were more accurate in labelling AMP as a stimulant. AMP also had a greater effect for Ds than for NDs on ratings of drug liking and general activity level during the day. Although Ds generally showed a stronger subjective response to AMP, Ds differed significantly from NDs on only 4 of 18 mood scales affected by AMP (2 anxiety scales and analog ratings of "stimulated" and "high"). Ds did not differ from NDs on any of the following measures: body weight, gender, current or lifetime drug use, baseline mood state, subjective response to placebo, or a variety of personality traits. The results demonstrate considerable individual differences in sensitivity to AMP and suggest a relationship between the DS effects of AMP and specific mood states.

show abstract

Acetazolamide Binding to Two Carbonic Anhydrase Isoenzymes in Human Erythrocytes

Bayne

Chu

Theeuwes

1979

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Sex Differences in Drug Evaluations

Cited by 4 publications

References 8 publications

A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects.

A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects.

Individual differences in the discriminative stimulus effects of d‐amphetamine in humans

Acetazolamide Binding to Two Carbonic Anhydrase Isoenzymes in Human Erythrocytes

Contact Info

Product

Resources

About