Sex differences in estrogen receptor accumulation in liver cell nuclei and increase of blood plasma angiotensinogen concentration after injection of low doses of synthetic estrogens in rats

Ignatenko, L. L.; Mataradze, G. D.; Bunyatyan, A. F.; Rozen, V. B.

doi:10.1007/bf00842581

Cited by 1 publication

(1 citation statement)

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“…However, variations in the amounts of liver estrogen receptors may partly explain the observed differences in responsiveness. Indeed, liver estrogen receptors are much more abundant in OVX female rats than in intact male rats (22); likewise, liver estrogen receptors are almost undetectable in HYPOX rats (22,30). To date, it has not been verified directly that a treatment that affects the levels of liver estrogen receptors also affects the response of AOG to estrogens in a similar fashion.…”

Section: Discussionmentioning

confidence: 96%

Regulation of the Angiotensinogen Gene by Estrogens in Rat Liver and Different Brain Regions

Hong-Brown

Deschepper

1993

Experimental Biology and Medicine

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Estrogens regulate the production of angiotensinogen (AOG) in liver and other tissues. However, evidence suggests that the effect is tissue specific and that it may depend on a variety of factors. We have tested the effects of ethynylestradiol (EE) on liver AOG mRNA and plasma AOG in intact male and ovariectomized female rats, as well as in hypophysectomized male rats. EE stimulated both variables to a comparable extent and in a dose-dependent manner. However, its effect on plasma AOG was significantly higher in female than in male rats. In addition, there was no response in hypophysectomized male rats; however, responsiveness was restored by pretreatment of the animals with prolactin. AOG mRNA concentration was also affected by EE in brain, but there were striking time- and region-specific differences. These results indicate that cell-specific factors also modulate the response of the AOG gene to EE in extrahepatic tissues.

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Section: Discussionmentioning

confidence: 96%