Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation

Hudry, Bruno; Goeij, Eva de; Mineo, Alessandro; Gaspar, Pedro; Hadjieconomou, Dafni; Studd, Chris; Mokochinski, João Benhur; Kramer, Holger; Plaçais, Pierre-Yves; Préat, Thomas; Miguel-Aliaga, Irene

doi:10.1016/j.cell.2019.07.029

Cited by 125 publications

(137 citation statements)

References 167 publications

(205 reference statements)

Supporting

Mentioning

129

Contrasting

Order By: Relevance

“…In turn, the gut receives multiple signals emanating from the fat body, brain and gonads to adjust digestion, metabolism and gut motility (blue lines). AKH, adipokinetic hormone; AKHR, AKH receptor; Daw, dawdle; DH44, diuretic hormone 44; DILPs, Drosophila insulin-like peptides; Upds, unpaired ligands spermatogenesis by increasing circulating citrate levels, demonstrating a role in the gonad-intestine axis in coupling diet and sperm production (Hudry et al, 2019). During pathogenic infections reallocation of energy takes place to support the energy expensive task of mounting an immune response.…”

Section: F I G U R Ementioning

confidence: 99%

“…The gut is well-positioned to sense fluctuation in the external environment, and it communicates extensively with other organs to allow a coordinated physiological response across tissues. One example is nutrient availability and/or quality, which is sensed by the gut and relayed to other organs to adjust metabolism, energy balance, and feeding behavior (Alfa et al, 2015;Hudry et al, 2019;Scopelliti et al, 2019;Song et al, 2017;Song, Veenstra, & Perrimon, 2014). Reversely, the gut receives nutrient information from the fat body, another important nutrient-sensing organ, and responds by adjusting ingestion, digestion, and absorption of nutrients according to nutrient abundance (Chng, Sleiman, Schupfer, & Lemaitre, 2014;Dus et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Drosophila gut: A gatekeeper and coordinator of organism fitness and physiology

Colombani

Andersen

2020

WIREs Developmental Biology

View full text Add to dashboard Cite

Multicellular organisms have evolved organs and tissues with highly specialized tasks. For instance, nutrients are assimilated by the gut, sensed, processed, stored, and released by adipose tissues and liver to provide energy consumed by peripheral organ activities. The function of each organ is modified by local clues and systemic signals derived from other organs to ensure a coordinated response accommodating the physiological needs of the organism. The intestine, which represents one of the largest interfaces between the internal and external environment, plays a key role in sensing and relaying environmental inputs such as nutrients and microbial derivatives to other organs to produce systemic responses. In turn, gut physiology and immunity are regulated by multiple signals emanating from other organs including the brain and the adipose tissues. In this review, we highlight physiological processes where the gut serves as a key organ in coupling systemic signals or environmental cues with organism growth, metabolism, immune activity, aging, or behavior. Robust strategies involving intraorgan and interorgan signaling pathways have evolved to preserve gut size in homeostatic conditions and restrict growth during damage-induced regenerative phases. Here we review some of the mechanisms that maintain gut size homeostasis and point out known examples of homeostasis-breaking events that promote gut plasticity to accommodate changes in the external or internal environment.

show abstract

Section: F I G U R Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Drosophila gut: A gatekeeper and coordinator of organism fitness and physiology

Colombani

Andersen

2020

WIREs Developmental Biology

View full text Add to dashboard Cite

show abstract

“…4a). To detect relative differences in lactate levels in loser and winner cells, we used a genetically encoded lactate reporter (UAS-lactate FRET) 23 , which we expressed throughout the entire tissue (nub-Gal4, UASlactate FRET). Clonal analysis was conducted via the LexA/lexO binary system 24 .…”

Section: Resultsmentioning

confidence: 99%

“…Imaging experiments were performed using dissected imaginal wing discs. A genetically encoded lactate reporter (UAS-lactate FRET) 23 , was co-expressed within clones expressing gene-of-interest (goi) or UAS-lacZ-RNAi. Alternatively, the sensor was expressed tissue wide, under the control of nubbin (nub-Gal4 > UAS-lactate FRET).…”

Section: Discussionmentioning

confidence: 99%

The NMDA receptor regulates competition of epithelial cells in the Drosophila wing

Bánréti

Meier

2020

Nat Commun

View full text Add to dashboard Cite

Cell competition is an emerging principle that eliminates suboptimal or potentially dangerous cells. For 'unfit' cells to be detected, their competitive status needs to be compared to the collective fitness of cells within a tissue. Here we report that the NMDA receptor controls cell competition of epithelial cells and Myc supercompetitors in the Drosophila wing disc. While clonal depletion of the NMDA receptor subunit NR2 results in their rapid elimination via the TNF/Eiger>JNK signalling pathway, local over-expression of NR2 causes NR2 cells to acquire supercompetitor-like behaviour that enables them to overtake the tissue through clonal expansion that causes, but also relies on, the killing of surrounding cells. Consistently, NR2 is utilised by Myc clones to provide them with supercompetitor status. Mechanistically, we find that the JNK>PDK signalling axis in 'loser' cells reprograms their metabolism, driving them to produce and transfer lactate to winners. Preventing lactate transfer from losers to winners abrogates NMDAR-mediated cell competition. Our findings demonstrate a functional repurposing of NMDAR in the surveillance of tissue fitness.

show abstract

“…Studies in Drosophila have led to a deep understanding of how sex chromosome number is interpreted to activate downstream pathways controlling morphological and behavioral differences between male and female flies. A recent study by Hudry et al (2019) comparing gene expression in the guts of males and females revealed male-biased expression of enzymes involved in carbohydrate transport and utilization. Hudry et al demonstrate that, surprisingly, this sex difference in gut gene expression is controlled by the adjacent male gonad, which produces the ligand Upd1.…”

Section: Organ Cross-talk and Sex Differences In Physiologymentioning

confidence: 99%

Drosophila melanogaster: a simple system for understanding complexity

Mohr

Perrimon

2019

Disease Models &Amp; Mechanisms

View full text Add to dashboard Cite

Understanding human gene function is fundamental to understanding and treating diseases. Research using the model organism Drosophila melanogaster benefits from a wealth of molecular genetic resources and information useful for efficient in vivo experimentation. Moreover, Drosophila offers a balance as a relatively simple organism that nonetheless exhibits complex multicellular activities. Recent examples demonstrate the power and continued promise of Drosophila research to further our understanding of conserved gene functions.

show abstract

Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation

Abstract: Highlights d Intestinal carbohydrate metabolism is male-biased and region-specific d Testes masculinize gut sugar handling by promoting enterocyte JAK-STAT signaling d The male intestine secretes citrate to the adjacent testes d Gut-derived citrate promotes food intake and sperm

Cited by 125 publications

References 167 publications

The Drosophila gut: A gatekeeper and coordinator of organism fitness and physiology

The Drosophila gut: A gatekeeper and coordinator of organism fitness and physiology

The NMDA receptor regulates competition of epithelial cells in the Drosophila wing

Drosophila melanogaster: a simple system for understanding complexity

Contact Info

Product

Resources

About