Sex Differences in Korsakoff's Syndrome for Inhibition but Not for Episodic Memory or Flexibility

Haj, Mohamad El; Kessels, Roy P. C.; Nandrino, Jean‐Louis

doi:10.1111/ajad.12999

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…Earlier research by El Haj et al also found evidence of sex differences between males and females diagnosed with KS. In their study, female patients showed a better inhibition behavior than males [38]. It would be of interest to investigate sex differences between people with KS in larger samples.…”

Section: Discussionmentioning

confidence: 89%

Self-Reported Pain and Pain Observations in People with Korsakoff’s Syndrome: A Pilot Study

Oudman,

van der Stadt,

Bidesie

et al. 2023

JCM

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Korsakoff’s syndrome (KS) is a chronic neuropsychiatric disorder. The large majority of people with KS experience multiple comorbid health problems, including cardiovascular disease, malignancy, and diabetes mellitus. To our knowledge pain has not been investigated in this population. The aim of this study was to investigate self-reported pain as well as pain behavior observations reported by nursing staff. In total, 38 people diagnosed with KS residing in a long-term care facility for KS participated in this research. The Visual Analogue Scale (VAS), Pain Assessment in Impaired Cognition (PAIC-15), Rotterdam Elderly Pain Observation Scale (REPOS), and the McGill Pain Questionnaire–Dutch Language Version (MPQ-DLV) were used to index self-rated and observational pain in KS. People with KS reported significantly lower pain levels than their healthcare professionals reported for them. The highest pain scores were found on the PAIC-15, specifically on the emotional expression scale. Of importance, the patient pain reports did not correlate with the healthcare pain reports. Moreover, there was a high correlation between neuropsychiatric symptoms and observational pain reports. Specifically, agitation and observational pain reports strongly correlated. In conclusion, people with KS report less pain than their healthcare professionals indicate for them. Moreover, there is a close relationship between neuropsychiatric symptoms and observation-reported pain in people with KS. Our results suggest that pain is possibly underreported by people with KS and should be taken into consideration in treating neuropsychiatric symptoms of KS as a possible underlying cause.

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Section: Discussionmentioning

confidence: 89%

Self-Reported Pain and Pain Observations in People with Korsakoff’s Syndrome: A Pilot Study

Oudman,

van der Stadt,

Bidesie

et al. 2023

JCM

View full text Add to dashboard Cite

show abstract

“…In patients with AUD, the severity of memory deficits is similar between men and women [ 71 ]. Regarding patients with KS, a recent study reported no gender effect on episodic memory performance [ 72 ]. Although we cannot assess this potential bias in our study, which constitutes a limitation, the studies reported above suggest that the observed group difference in episodic memory is unlikely to be attributed to a gender effect.…”

Section: Discussionmentioning

confidence: 99%

Distinct Sleep Alterations in Alcohol Use Disorder Patients with and without Korsakoff’s Syndrome: Relationship with Episodic Memory

Lanièpce

Segobin

André

et al. 2023

JCM

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Alcohol Use Disorder (AUD) results in sleep disturbances that may have deleterious impacts on cognition, especially on memory. However, little is known about the sleep architecture in patients with Korsakoff’s syndrome (KS). This study aims at characterizing sleep disturbances in KS compared to AUD without KS and at specifying the relationships with cognitive impairments. Twenty-nine AUD patients (22 without KS and 7 with KS) and 15 healthy controls underwent a neuropsychological assessment and a polysomnography. The severity of sleep-disordered breathing and sleep fragmentation was similar in AUD and KS patients compared to controls. Sleep architecture differed between both patient groups: the proportion of slow-wave sleep was reduced in AUD patients only, while a lower proportion of rapid-eye movement (REM) sleep was specifically observed in KS patients. The proportion of REM sleep correlated with the severity of episodic memory deficits when AUD and KS were examined together. These data provide evidence for both similarities and specificities regarding sleep alterations in AUD patients with and without KS. They also indicate that altered sleep architecture may contribute to the pathophysiology of alcohol-related memory disorders.

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Intentional and unintentional mind-wandering in Korsakoff syndrome

Haj

Nandrino

2021

Psychiatry Research

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Sex Differences in Korsakoff's Syndrome for Inhibition but Not for Episodic Memory or Flexibility

Cited by 5 publications

References 37 publications

Self-Reported Pain and Pain Observations in People with Korsakoff’s Syndrome: A Pilot Study

Self-Reported Pain and Pain Observations in People with Korsakoff’s Syndrome: A Pilot Study

Distinct Sleep Alterations in Alcohol Use Disorder Patients with and without Korsakoff’s Syndrome: Relationship with Episodic Memory

Intentional and unintentional mind-wandering in Korsakoff syndrome

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