Sex differences in left ventricular function in older persons with mild hypertension

Lim, Jimmy G.; Shapiro, Edward P.; Vaidya, Dhananjay; Najjar, Samer S.; Turner, Katherine; Bacher, Anita C.; Ouyang, Pamela; Stewart, Kerry J.

doi:10.1016/j.ahj.2005.01.013

Cited by 9 publications

(9 citation statements)

References 47 publications

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“…Notably, epidemiological studies have shown that women are at higher risk of developing HF in the setting of pressure overload states, such as hypertension and aortic stenosis. Although it appears that age-related changes in systolic and diastolic function in these women are more pronounced on echocardiography [45], gender was not independently associated with diastolic dysfunction in our study. It is possible, however, that women with diastolic dysfunction due to CHD represent a distinct phenotype from hypertensive women, and that they are in fact similar to their male counterparts.…”

Section: Discussioncontrasting

confidence: 91%

C‐reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study

Williams

Shah

Ali

et al. 2008

European J of Heart Fail

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Background: High-sensitivity C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) and, in recent studies, incident heart failure (HF). Whether the association of inflammation with incident HF is explained by worse baseline left ventricular dysfunction or by underlying CHD is unknown. Methods and results: Serum CRP was measured in a cohort of 985 outpatients with established CHD from the Heart and Soul Study. During 3 years of follow-up, 15% of the participants with elevated CRP levels (N3 mg/L) were hospitalised for HF, compared with 7% of those with CRP ≤3 mg/L. In multivariate analysis, elevated CRP was associated with HF after adjustment for traditional risk factors, baseline CHD severity and interim MI (adjusted HR 2.1, 95% CI, 1.2-3.6; p = 0.009). However, elevated CRP was no longer associated with HF after further adjustment for the presence of diastolic dysfunction on echocardiography (adjusted HR 1.6, 95% CI, 0.8-3.2; p = 0.1). Conclusions: Among outpatients with stable CHD, elevated CRP levels predict hospitalisation for heart failure, independent of baseline heart failure, medication use, CHD severity, and subsequent MI events. This relationship appears to be at least partly explained by abnormal diastolic function in patients with elevated CRP levels.

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Section: Discussioncontrasting

confidence: 91%

C‐reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study

Williams

Shah

Ali

et al. 2008

European J of Heart Fail

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“…Previous work has shown a stronger association among women than men between hypertension and microabluminuria, 2 left ventricular hypertrophy, 2 and baroreceptor reflex sensitivity, 25 and greater reductions in systolic and diastolic function. 26 However, limited work has examined possible sex differences in the association between midadulthood BP and dementia risk with inconsistent results. In our analyses, the relationship between hypertension in mid-adulthood (and early adulthood) and dementia risk was present only among women.…”

Section: Figurementioning

confidence: 99%

Female sex, early-onset hypertension, and risk of dementia

et al. 2017

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“…al [40]. Furthermore, women with mild hypertension showed greater reductions in BP, as they age, and have an increased risk of developing heart failure [41]. We are partly dealing with the effects of selection bias concerning subjects examined with CBF measurement at the age of 83, because subjects with severe vascular risk profiles might not have reached such high age.…”

Section: Discussionmentioning

confidence: 99%

Cardiac ventricular dimensions predict cognitive decline and cerebral blood flow abnormalities in aging men

et al. 2013

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BackgroundThe aims of this study are to examine possible associations between left cardiac ventricular measures in sixth decade and cognitive performance, both cross sectionally and longitudinally, and to examine if left cardiac ventricular measures could predict future changes in cerebral blood flow (CBF).Methods211 elderly men from a cohort of the population study “Men born in 1914” completed M-mode echocardiography and a cognitive test battery at age 68. The cognitive test battery was repeated at age 81. CBF was estimated with 99mTc-HMPAO SPECT in 72 survivors at age 83. Cognitive performance at baseline and at 1st follow up and CBF at 1st follow up were analysed in relation to left ventricular internal dimension in diastole (LVIDd mm/m2) and fractional shortening (FS).ResultsSubjects with enlarged LVIDd at age 68 had poorer results on verbal and speed-performance tests at baseline and on verbal and visuo-spatial tests 14 years later on. Low FS was associated with decreased results on visuo-spatial tests at baseline. There was an inverse relationship between LVIDd and both verbal and spatial ability at the baseline and after 14 years of follow-up. Normotensive men with lower FS had also decreased CBF in a majority of brain areas 14 years later.ConclusionsMild echocardiographic abnormalities in 68 ys.-old men, as increased LVIDd and lower FS, are associated with lower cognitive test results and may predict cognitive decline and silent cerebral perfusion abnormalities 14 years later.

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Sex differences in left ventricular function in older persons with mild hypertension

Cited by 9 publications

References 47 publications

C‐reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study

C‐reactive protein, diastolic dysfunction, and risk of heart failure in patients with coronary disease: Heart and Soul Study

Female sex, early-onset hypertension, and risk of dementia

Cardiac ventricular dimensions predict cognitive decline and cerebral blood flow abnormalities in aging men

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