Sex differences in locomotor activity after acute and chronic cocaine administration

Haaren, Frans van; Meyer, Merle E.

doi:10.1016/0091-3057(91)90054-6

Cited by 186 publications

(127 citation statements)

References 17 publications

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“…1 Sex Differences in Cocaine Effects 119 particularly well known for producing greater behavioral effects in female rats following acute administration (Schneider and Norton 1979;Savageau and Beatty 1981;Becker et al 1982;Camp et al 1986;Camp and Robinson 1988a). Acute cocaine administration has also been reported to induce greater behavioral effects in female rats (van Haaren and Meyer 1991;Haney et al 1994;Bowman and Kuhn 1996) and in mice (Sershen et al 1998). However, in other reports, sex differences in acute cocaine-stimulated motor behavior were not observed in naïve Sprague-Dawley rats (Craft and Stratman 1996) and in three other rat strains (Cailhol and Mormede 1999).…”

Section: ) Cocaine Increased Stereotypy Rating Horizontal and Vertmentioning

confidence: 62%

Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy

Walker

Cabassa

Kaplan

et al. 2001

Neuropsychopharmacology

112

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Sex differences in biological substrates of drug use and addiction are poorly understood. The present study investigated sexual dimorphisms in motor behavior following acute cocaine administration (10, 20, or 40 mg/ kg, i.p Little is known about sex differences in biologic substrates of drug taking and addiction. However, an emerging literature documents that sex differences in the behavioral responses to addictive drugs exist in humans. A sex difference in human affective responses to cocaine has been reported in one study in which females reported more nervousness than males following intranasal cocaine (Kosten et al. 1996). Lukas and coworkers (1996) showed that cocaine induced similar cardiovascular and affective responses in men and women, although plasma concentrations of cocaine were lower in women. In a laboratory setting, cocaine cues induced more drug craving in female than male addicts (Robbins et al. 1999). These results suggest that women may be more sensitive to cocaine than men. In fact, women begin using cocaine and enter treatment at earlier ages than men (Griffin et al. 1989;Mendelson et al. 1991) and have more severe cocaine use at intake than men (Kosten et al. 1993). .). Cocaine increased stereotypy rating, horizontal and vertical activity in both sexes, and effects were always greater in females than males. A population analysis using data from multiple experiments indicated that horizontal activity scores were normally distributed in males butSex differences in spontaneous and drug-stimulated behavior have been carefully studied in animals. Probably the most robust sex difference in behavior is the observation that female rats exhibit more running wheel activity than males (for review see Beatty 1979). Female rats are also often reported to be more active than males in open-field situations (Beatty 1979). These sex differences in basal or non-stimulated behavior are likely related to the reported sex differences in open-field behavior following psychomotor stimulant administration (van Hartesveldt and Joyce 1986 25 , NO . 1 Sex Differences in Cocaine Effects 119 particularly well known for producing greater behavioral effects in female rats following acute administration (Schneider and Norton 1979;Savageau and Beatty 1981;Becker et al. 1982;Camp et al. 1986;Camp and Robinson 1988a). Acute cocaine administration has also been reported to induce greater behavioral effects in female rats (van Haaren and Meyer 1991;Haney et al. 1994;Bowman and Kuhn 1996) and in mice (Sershen et al. 1998). However, in other reports, sex differences in acute cocaine-stimulated motor behavior were not observed in naïve Sprague-Dawley rats (Craft and Stratman 1996) and in three other rat strains (Cailhol and Mormede 1999). Thus, better evidence of sex-differences in acute behavioral effects in intact animals exists for amphetamine than cocaine. Gonadal and especially ovarian hormones have been investigated as likely modulators of these sex differences in behavior. Ovarian hormone effects on stimulant respon...

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Section: ) Cocaine Increased Stereotypy Rating Horizontal and Vertmentioning

confidence: 62%

Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy

Walker

Cabassa

Kaplan

et al. 2001

Neuropsychopharmacology

112

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“…For example, several studies have shown no effect of castration on cocaine self-administration (this study , behavioral sensitization to cocaine (Hu and Becker, 2003), or acute or chronic cocaine administration (van Haaren and Meyer, 1991). However, others have seen differences between intact and castrated males in the behavioral response to cocaine (Chin et al, 2002) and AMPH (Robinson, 1984).…”

Section: Effects Of Gonadal Hormones On Male Cocaine Self-administrationmentioning

confidence: 68%

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Jackson

Robinson

Becker

2005

Neuropsychopharmacol

285

272

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Men and women differ in their response to cocaine, and a woman's response varies with the menstrual cycle. For example, women have greater subjective responses to cocaine in the follicular phase of the menstrual cycle when estradiol is predominant, than they do during the luteal phase when both estradiol and progesterone are elevated. Similarly, female rats show significantly more cocaine-induced locomotor behavior and cocaine self-administration during behavioral estrus, shortly after estradiol peaks, than during other stages of the cycle, and estradiol administration to ovariectomized (OVX) females enhances the acquisition of cocaine self-administration. The purpose of this study was to expand upon these findings by studying the effects of progesterone administration to females, and estradiol administration to males, on acquisition of cocaine self-administration. We report here that there are both sex differences in and effects of circulating ovarian hormones on acquisition of cocaine self-administration. We demonstrate that although estradiol administration enhances acquisition of cocaine self-administration in OVX female rats, concurrent administration of progesterone with estradiol inhibits this effect of estradiol. In a separate experiment, we demonstrate that estradiol administration does not enhance acquisition of cocaine self-administration in castrated male rats. We conclude that (1) there is a sex difference in the effects of estradiol on cocaine selfadministration: it facilitates acquisition in female, but not male rats; and that (2) in females concurrent progesterone treatment counteracts the facilitory effect of estradiol on cocaine self-administration.

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“…Female rats show greater behavioral sensitization after repeated cocaine injections than do male rats (Glick et al, 1984;van Haaren et al, 1991;Chin et al, 2002;Hu et al, 2003). They also acquire cocaine self-administration more readily than male rats (Lynch et al, 1999;Lynch et al, 2001;Carroll et al, 2002;Hu et al, 2004).…”

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confidence: 92%

Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration

Becker

2008

Drug and Alcohol Dependence

123

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This study was conducted to investigate whether the dose of estradiol (E) administered acutely, or chronic delivery of one dose of E impacts acquisition and subsequent cocaine self-administration in ovariectomized (OVX) female rats. Five groups of female rats were compared: OVX females treated with 0, 1, 2, or 5 µg 17 β-E, 30 min prior to the self-administration session, and OVX rats that received a 1.5 mg E pellet (designed to chronically release 25 µg E/d X 60 d) implanted 1 week before cocaine self-administration initiation. Rats were tested in 1 hr sessions on a FR1 schedule with the dose of cocaine increasing every week (testing occurred 5 day/wk; doses: 0.2, 0.3, 0.4, 0.5 and 0.75 mg/kg/ infusion). We report that OVX rats treated with 2 µg E acquired self-administration more rapidly than all of the other groups, and animals that received 1 or 2 µg E self-administered significantly more cocaine compared to OVX+vehicle at 0.3 and 0.4 mg/kg/infusion. In contrast, OVX rats given 5 µg E acutely, or chronic E via slow-release pellets did not take more cocaine than the OVX+vehicle group at any time point. Physiological serum concentrations of E were seen with 1 or 2 µg E, but 5 µg E and the E pellet produced supra-physiological concentrations. These results suggest an inverted U-shaped dose-response curve for the effect of E on acquisition of cocaine self-administration.

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Sex differences in locomotor activity after acute and chronic cocaine administration

Cited by 186 publications

References 17 publications

Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy

Sex Differences in Cocaine-Stimulated Motor Behavior Disparate Effects of Gonadectomy

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Acquisition of cocaine self-administration in ovariectomized female rats: Effect of estradiol dose or chronic estradiol administration

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