Sex differences in muscle contraction-induced limb blood flow limitations

Hammer, Shane M.; Sears, Kylie N.; Montgomery, Tony R.; Olmos, Alex A.; Hill, Ethan C.; Trevino, Michael A.; Dinyer-McNeely, Taylor K.

doi:10.1007/s00421-023-05339-5

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Kagaya et al [ 15 ] demonstrated that in response to static handgrip exercise in twenty year-old female tennis players, recovery brachial artery diameter and blood flow is greater in the trained forearm. While the completion of static exercise may impede flow consistently between 10–90% of maximal effort [ 29 ] and therefore between limbs, females may experience less contraction induced impairments in blood flow compared to males [ 30 ]. The present observations provide support that the hemodynamic response to non-ischemic exercise is equivalent.…”

Section: Discussionmentioning

confidence: 99%

The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation

Schwartz,

Fongwoo,

Bentley

2024

PLoS ONE

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The human forearm model is commonly employed in physiological investigations exploring local vascular function and oxygen delivery; however, the effect of arm dominance on exercising forearm hemodynamics and skeletal muscle oxygen saturation (SmO2) in untrained individuals is poorly understood. Therefore, the purpose of this study was to explore the effect of self-identified arm dominance on forearm hemodynamics and SmO2 in untrained individuals during submaximal, non-ischemic forearm exercise. Twenty healthy individuals (23±4 years, 50% female; 80% right-handed) completed three-minute bouts of supine rhythmic (1 second contraction: 2 second relaxation duty cycle) forearm handgrip exercise at both absolute (10kg; 98N) and relative (30% of maximal voluntary contraction) intensities in each forearm. Beat-by-beat measures of forearm blood flow (FBF; ml/min), mean arterial blood pressure (MAP; mmHg) and flexor digitorum superficialis SmO2 (%) were obtained throughout and averaged during the final 30 seconds of rest, exercise, and recovery while forearm vascular conductance was calculated (FVC; ml/min/100mmHg). Data are Δ from rest (mean±SD). Absolute force production did not differ between non-dominant and dominant arms (97±11 vs. 98±13 N, p = 0.606) whereas relative force production in females did (69±24 vs. 82±25 N, p = 0.001). At both exercise intensities, FBFRELAX, FVCRELAX, MAPRELAX, and the time constant tau for FBF and SmO2 were unaffected by arm dominance (all p>0.05). While arm dominance did not influence SmO2 during absolute intensity exercise (p = 0.506), the non-dominant arm in females experienced an attenuated reduction in SmO2 during relative intensity exercise (-14±10 vs. -19±8%, p = 0.026)–though exercise intensity was also reduced (p = 0.001). The present investigation has demonstrated that arm dominance in untrained individuals does not impact forearm hemodynamics or SmO2 during handgrip exercise.

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Section: Discussionmentioning

confidence: 99%

The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation

Schwartz,

Fongwoo,

Bentley

2024

PLoS ONE

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How does the dose and type of exercise impact acute cardiovascular function in healthy individuals?

Bentley,

Nikolovski,

Goodman

2024

Canadian Journal of Cardiology

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Sex differences in the cardiopulmonary and neuromuscular response to high-intensity interval exercise

Wilson,

Bernert,

Spillane

et al. 2024

Preprint

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Sex differences exist in the integrative response to exercise, however, these are typically researched during constant-load exercise. Interval exercise involves high-intensity efforts interspersed with recovery periods to repeatedly stress physiological systems, and it is currently unknown whether the response to this form of exercise differs between sexes. Ten males and ten females (age: 25 +/- 3 years) completed two experimental visits. First, an incremental treadmill exercise test was performed to obtain submaximal (lactate threshold) and maximal (VO2peak) data. Thereafter, visit two involved 4 x 3-min running intervals at 90% of the final incremental test velocity (vVO2peak), with 90 secs rest between intervals. Before exercise and after each interval, maximal voluntary contraction (MVC), quadriceps potentiated twitch (Qtw.pot), and voluntary activation (VA) were recorded. The rates of oxygen uptake (VO2), carbon dioxide production (VCO2) and ventilation (VE) were continuously recorded throughout. There was no sex difference in relative VO2peak (males: 47.2 +/- 6.0 vs. females: 44.4 +/- 5.8 ml.kg-1.min-1, p=0.292). When expressed relative to peak values, there were no sex differences in the VO2 or VCO2 response to the interval task (p greater than or equal to 0.781). Females had greater VE, VE/VO2, and VE/VCO2 values during the first two intervals (p less than or equal to 0.046). There were no sex differences in the reductions in MVC, Qtw.pot, and VA during the interval task (p greater than or equal to 0.150), however females had lesser reductions in Qtw.pot values post-exercise (-24 +/- 9 vs. -15 +/- 8%, p=0.044). Sex differences exist in the physiological response to interval exercise. Compared to males, females experienced greater hyperpnoea during the initial stages, and had lesser decreases in contractile function post-exercise.

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Sex differences in muscle contraction-induced limb blood flow limitations

Cited by 3 publications

References 40 publications

The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation

The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation

How does the dose and type of exercise impact acute cardiovascular function in healthy individuals?

Sex differences in the cardiopulmonary and neuromuscular response to high-intensity interval exercise

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