Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins

Ryan, Alice S.; Li, Guoyan

doi:10.1177/15353702221142619

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…It is important to note that we did not find significant differences of SIRT1 expression or FMD after energy restriction (Table 1), but only correlations (baseline SIRT1 expression and ∆FMD) which may not necessarily reflect causality. Women did not have this association because, perhaps, of the fact that they presented, in the basal state, higher SIRT1 [50,51] and FMD [54] than men due to estrogens, and the interventions of the present study were not sufficient to optimize these parameters in this group.…”

Section: Discussioncontrasting

confidence: 55%

“…Laboratory studies showed that, in female rats, estrogen activated the SIRT1/AMPK signaling pathway, increasing protection against cerebral ischemic stress [46] and angiotensin (Ang) II-induced cardiomyocyte hypertrophy [47], which could explain the mechanisms behind the epidemiological differences of cardiovascular diseases between men and women [48,49]. Previous studies showed differences between men and women regarding sirtuin levels in heart and skeletal muscle tissues [50,51], corroborating the hypothesis that women have an increased baseline sirtuin content, probably due to higher levels of circulating estrogens. Therefore, our results support that interventions that increase SIRT1 may be more effective in men with lower baseline SIRT1.…”

Section: Discussionmentioning

confidence: 99%

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Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

et al. 2023

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Background: Sirtuin 1 (SIRT1) has been associated with longevity and protection against cardiometabolic diseases, but little is known about how it influences human vascular function. Therefore, this study evaluated the effects of SIRT1 activation by resveratrol and energy restriction on vascular reactivity in adults. Methods: A randomized trial allocated 48 healthy adults (24 women and 24 men), aged 55 to 65 years, to resveratrol supplementation or energy restriction for 30 days. Blood lipids, glucose, insulin, C-reactive protein, noradrenaline, SIRT1 (circulating and gene expression), and flow-mediated vasodilation (FMD) and nitrate-mediated vasodilation (NMD) were measured. Results: Both interventions increased circulating SIRT1 (p < 0.001). Pre- and post-tests changes of plasma noradrenaline were significant for both groups (resveratrol: p = 0.037; energy restriction: p = 0.008). Baseline circulating SIRT1 was inversely correlated with noradrenaline (r = −0.508; p < 0.01), and post-treatment circulating SIRT1 was correlated with NMD (r = 0.433; p < 0.01). Circulating SIRT1 was a predictor of FMD in men (p = 0.045), but not in women. SIRT1 was an independent predictor of NMD (p = 0.026) only in the energy restriction group. Conclusions: Energy restriction and resveratrol increased circulating SIRT1 and reduced sympathetic activity similarly in healthy adults. SIRT1 was independently associated with NMD only in the energy restriction group.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

et al. 2023

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“…Based on our results, we extend findings in the literature that there are baseline sex differences in skeletal muscle metabolism [7][8][9][10], specifically the change in GS fractional and independent activity and AKT protein expression with insulin stimulation. Also, basal AMPK, GSK-3β, ERK1/2, and p38 are each lower in older men than in older women.…”

Section: Discussionsupporting

confidence: 87%

“…We have also found that middle‐aged and older women have higher adipose tissue expression of adiponectin, an adipokine that regulates lipid and glucose metabolism, and higher adipose and skeletal muscle tissue expression of liver receptor homolog‐1 (LRH‐1), a nuclear receptor that regulates lipid metabolism, than similar aged men [8]. Furthermore, we have reported higher skeletal muscle expression of sirtuins SIRT1 and SIRT3 , genes involved in metabolic homeostasis [9], and lower myostatin expression in women than men [10]. Taken together, these results suggest that differences between men and women in both adipose tissue and skeletal muscle contribute to the overall observed sex differences regulating metabolism that occur with age.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in insulin regulation of skeletal muscle glycogen synthase and changes during weight loss and exercise in adults

Ryan,

Li,

McMillin

et al. 2024

Obesity

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ObjectiveThe authors sought to understand sex differences in muscle metabolism in 73 older men and women.MethodsBody composition, VO2max, and insulin sensitivity (M) by 3‐hour hyperinsulinemic‐euglycemic clamp with vastus lateralis muscle biopsies were measured.ResultsWomen had lower body weight, VO2max, and fat‐free mass than men. Men had lower M, lower change (insulin minus basal) in muscle glycogen synthase (GS) activity, and lower change in AKT protein expression than women. M was associated with the change (insulin‐basal) in GS activity and the change in AKT protein expression. Sex differences (n = 60) were tested with 6‐month weight loss or 3×/week aerobic exercise training. The postintervention minus preintervention change (insulin‐basal) (∆∆) in GS activity (fractional, independent, total) was higher in men than women in the weight loss group and ∆∆ in GS fractional activity was higher in women than men in the aerobic exercise group. In all participants, ∆∆ in GS fractional and independent activities was related to ∆∆ in AKT expression and glycogen content.ConclusionsSex differences in insulin sensitivity may be explained at the cellular muscle level, and to improve skeletal muscle insulin action in older adults, it may be necessary to recommend different behavioral strategies depending on the individual's sex.

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“…By contrast to androgen levels in males, androgen levels in females are naturally in the castration range (Matsumoto & Bremner, 2004). Despite naturally low androgen levels, SIRT1 levels in the limb muscle of females are reported to be higher than in the muscle of testicular intact males (Ryan & Li, 2023). Therefore, it was not surprising that neither total lean mass, nor limb muscle mass was enhanced by increasing SIRT1 protein in the muscle of females, probably because the females already had sufficient SIRT1 levels to maintain limb muscle mass (i.e.…”

Section: Discussionmentioning

confidence: 99%

SIRT1 induction in the skeletal muscle of male mice partially preserves limb muscle mass but not contractile force in response to androgen deprivation

Gordon

Burns

Laskin

et al. 2023

The Journal of Physiology

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In males, the factors that decrease limb muscle mass and strength in response to androgen deprivation are largely unknown. Sirtuin1 (SIRT1) protein levels are lower in the limb muscle of male mice subjected to androgen deprivation. The present study aimed to assess whether SIRT1 induction preserved limb muscle mass and force production in response to androgen deprivation. Physically mature male mice containing an inducible muscle‐specific SIRT1 transgene were subjected to a sham or castration surgery and compared to sham and castrated male mice where the SIRT1 transgene was not induced. SIRT1 induction partially preserved whole‐body lean mass, tibialis anterior (TA) mass and triceps surae muscle mass in response to castration. Further analysis of the TA muscle showed that muscle‐specific SIRT1 induction partially preserved limb muscle soluble protein content and fibre cross‐sectional area. Unilateral AAV9‐mediated SIRT1 induction in the TA muscle showed that SIRT1 partially preserved mass by acting directly in the muscle. Despite those positive outcomes to limb muscle morphology, muscle‐specific SIRT1 induction did not preserve the force generating capacity of the TA or triceps surae muscles. Interestingly, SIRT1 induction in females did not alter limb muscle mass or limb muscle strength even though females have naturally low androgen levels. SIRT1 also did not alter the androgen‐mediated increase in limb muscle mass or strength in females. In all, these data suggest that decreases in SIRT1 protein in the limb muscle of males may partially contribute to the loss of limb muscle mass in response to androgen deprivation. imageKey points SIRT1 induction in skeletal muscle of male mice subjected to androgen deprivation partially preserved limb muscle mass and fibre cross‐sectional area. SIRT1 induction in skeletal muscle of male mice subjected to androgen deprivation did not prevent preserve limb muscle force generating capacity. SIRT1 induction in skeletal muscle of females did not alter baseline limb muscle mass, nor did it affect the androgen‐mediated increase in limb muscle mass.

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Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins

Cited by 4 publications

References 35 publications

Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

Sex differences in insulin regulation of skeletal muscle glycogen synthase and changes during weight loss and exercise in adults

SIRT1 induction in the skeletal muscle of male mice partially preserves limb muscle mass but not contractile force in response to androgen deprivation

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