Sex differences in neuroimmunoendocrine communication. Involvement on longevity

Suárez, Luz M.; Cerro, Estefanía Díaz-Del; Félix, Judith; González‐Sánchez, Mónica; Ceprián, Noemí; Guerra-Perez, Natalia; Novelle, Marta G.; Toda, Irene Martínez de; Fuente, Mónica De la

doi:10.1016/j.mad.2023.111798

Cited by 9 publications

(3 citation statements)

References 321 publications

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“…On the contrary, WT PS males showed an impairment of their innate immune function. This sex difference would be due to the fact that the final release of glucocorticoids and corticosteroids is highly influenced by gonadal hormones and genes on the sex chromosome [ 24 ]. With regard to adaptive functions, there are no differences in any WT group that were obtained, which could be due to the type of stress, since, being a punctual stress, it would not be so prolonged as to intervene with the adaptive immunity [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on that, the aim of the present study was to investigate the effect in the behavior, immunity, and oxidative state of an acute stress by restraint in TH-HZ mice, and to determine the differences compared to the response in WT mice. In addition, it is known that there are sex differences in the functions of homeostatic systems and in the involvement of these systems in the response to stress situations [ 24 ]. Since these sex differences in the stress response of TH-HZ mice are still unknown, this aspect was also studied.…”

Section: Introductionmentioning

confidence: 99%

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In Response to a Punctual Stress Male and Female Tyrosine Hydroxylase Haploinsufficient Mice Show a Deteriorated Behavior, Immunity, and Redox State

Félix

Garrido

Fuente

2023

IJMS

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An inadequate stress response is associated with impaired neuroimmunoendocrine communication, increasing morbidity and mortality. Since catecholamines (CA) constitute one of the acute stress response pathways, female mice with an haploinsufficiency of the tyrosine hydroxylase gene (TH-HZ), the main limiting enzyme in CA synthesis, show low CA amounts, exhibiting an impairment of homeostatic systems. The aim of this study was to investigate the effect of a punctual stress in TH-HZ mice, determining the differences with wild-type (WT) mice and those due to sex by restraint with a clamp for 10 min. After restraint, a behavioral battery was performed, and several immune functions, redox state parameters, and CA amounts were evaluated in peritoneal leukocytes. Results show that this punctual stress impaired WT behavior and improved female WT immunity and oxidative stress, whereas in TH-HZ mice, all parameters were impaired. In addition, different responses to stress due to sex were observed, with males having a worse response. In conclusion, this study confirms that a correct CA synthesis is necessary to deal with stress, and that when a positive stress (eustress) occurs, individuals may improve their immune function and oxidative state. Furthermore, it shows that the response to the same stressor is different according to sex.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Response to a Punctual Stress Male and Female Tyrosine Hydroxylase Haploinsufficient Mice Show a Deteriorated Behavior, Immunity, and Redox State

Félix

Garrido

Fuente

2023

IJMS

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“…In this study, we examined only IL-1β and IL-1RA levels (per platelet [PLT] count); thus, further investigations are needed to provide a comprehensive understanding of these sex-based differences. However, the existing literature indicates that female athletes exhibit greater inflammatory responses [36][37][38], which may indicate possible differences in these cytokine levels in PRP, especially leukocytecontaining PRP, L-PRP. If other proinflammatory and anti-inflammatory cytokine levels align with the trends observed for IL-1β and IL-1RA levels, it may suggest that although fCAs have significantly lower levels of representative growth factors in their PRP, tissue regeneration might proceed at a faster, or at least equal, rate than that in mPSPs by effectively controlling the inflammatory phase of the healing process.…”

Section: Higher Levels Of Inflammation-related Cytokines In Fcas' L-prpmentioning

confidence: 99%

Elevated IL-1β and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players

Mochizuki,

Ushiki,

Suzuki

et al. 2023

IJMS

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Autologous platelet-rich plasma (PRP) therapy has been becoming popular for the treatment of musculotendinous injuries among athletes. However, for individual and practical variations, clinical success is hardly predictable. To overcome this difficulty, we have been exploring possible criterion candidates for monitoring its clinical effectiveness. In this study, we focused on sex-based differences in young elite athletes and compared the biochemical compositions of their PRP. Leukocyte-rich PRP (L-PRP) was manually prepared from blood samples collected from male professional soccer players (mPSPs) (n = 25) and female college athletes (fCAs) (n = 36). Platelet-derived growth factor-BB (PDGF-BB), transforming-growth factor-β1 (TGFβ1), platelet factor-4 (PF4), interleukin-1β (IL-1β), and IL-1 receptor antagonist (IL-1RA) were quantified using an enzyme-linked immunosorbent assay. The levels of PDGF-BB, TGFβ1, and PF4 in L-PRP were significantly higher in mPSPs than in fCAs. Conversely, IL-1β and IL-1RA were detected at significantly and slightly higher levels, respectively, in fCAs than in mPSPs. Our findings suggest that, even though L-PRP from fCAs may have lower potential to induce cell growth and differentiation than that of mPSPs, due to the latter’s higher capacity to control inflammation, it does not necessarily imply that PRP treatment in fCAs is less effective. Thus, these cytokine levels should be checked before PRP therapy.

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High exposure to carrageenan in young mice may impair behavior, immunity, redox and inflammatory states throughout the aging process

Félix,

Bellanco,

Díaz-Del Cerro

et al. 2024

Food Research International

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Sex differences in neuroimmunoendocrine communication. Involvement on longevity

Cited by 9 publications

References 321 publications

In Response to a Punctual Stress Male and Female Tyrosine Hydroxylase Haploinsufficient Mice Show a Deteriorated Behavior, Immunity, and Redox State

In Response to a Punctual Stress Male and Female Tyrosine Hydroxylase Haploinsufficient Mice Show a Deteriorated Behavior, Immunity, and Redox State

Elevated IL-1β and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players

High exposure to carrageenan in young mice may impair behavior, immunity, redox and inflammatory states throughout the aging process

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