Sex differences in Parkinson’s disease

Lubomski, Michal; Rushworth, R. Louise; Lee, Will; Bertram, Kelly; Williams, David R.

doi:10.1016/j.jocn.2013.12.016

Cited by 97 publications

(87 citation statements)

References 24 publications

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“…In the comparison of NMSs, PD patients showed higher scores in PDQ-39 compared to normal controls especially in female patients, and our result is in good agreement with previous studies [13,14]. Over the course of the disease, patients with PD experience changes in their HRQoL that are affected by some NMSs and an increased prevalence of several comorbid conditions.…”

Section: Discussionsupporting

confidence: 92%

Gender Differences of Nonmotor Symptoms Affecting Quality of Life in Parkinson Disease

et al. 2017

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Background/Aims: Gender differences of health-related quality of life (HRQoL) in patients with various disorders have been reported. Various nonmotor symptoms (NMSs) also affect the patients' lives and HRQoL, even in the early stages of Parkinson disease (PD). Our study aimed to identify whether there are gender differences of HRQoL in PD patients in the early stages, and which NMSs are associated with HRQoL depending on gender. Method: Eighty-nine PD patients (47 males, 42 females) and 36 healthy controls were enrolled. We evaluated HRQoL, NMSs, and their associations in each gender. Result: The total Parkinson Disease Quality of Life Questionnaire and Beck Anxiety Inventory scores were higher in female patients than in male patients. The correlation analysis revealed no association between NMSs and HRQoL in male patients. In female patients, HRQoL was highly correlated with depression, and moderately associated with fatigue. Conclusions: Gender differences of an association between HRQoL and NMSs exist in PD. We found that fatigue and depression were the main determinants of poor HRQoL in female patients even in the early stages. We suggest that a gender-specific therapeutic approach is important, and it is necessary to pay special attention to the predictors associated with causing poor HRQoL.

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Section: Discussionsupporting

confidence: 92%

Gender Differences of Nonmotor Symptoms Affecting Quality of Life in Parkinson Disease

et al. 2017

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“…Furthermore, loss of cognition function affected males more than females, and this was based on the high level of significance compared to females. The results were consistent with previous literature that had investigated sex differences in PD, suggesting that daily life activities might become affected by the cognitive decline in males more than females [46,65,67]. Moreover, autonomic dysfunction was found to be significantly higher in PD patients than in HC.…”

Section: Demographics Characteristics Analysissupporting

confidence: 91%

“…Moreover, significant differences between both sexes were not found in the current study, and this might be related to the short disease duration at the baseline of the study. However, in a recent study that used a higher disease duration (total PD subjects (years): 7.3 ± 5.7; males (years): 7.4 ± 5.7; females (years): 7 ± 5.8), males showed considerably higher movement defect scores than females [65]. To evaluate the disease progression, the Hoehn and Yahr test was performed as a baseline of the disease.…”

Section: Demographics Characteristics Analysismentioning

confidence: 99%

Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

Alqarni¹

2017

J Neurol Disord

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“…Sexual dimorphism of astrocytes might at least partly explain the known gender differences in some neurodegenerative processes, such as higher susceptibility of women to multiple sclerosis and the tendency of men for a more progressive course of the disease (251). The prevalence and incidence of Parkinson's disease, on the other hand, are higher in men compared with women, and sexrelated differences have also been observed in the type of neuropsychiatric and cognitive changes as well as motor symptoms of Parkinson's and Huntington's disease (140,219). Whether a specific modulation of astrocyte activation or function would show sexually dimorphic effects on the progression of chronic neurodegeneration or outcome after brain ischemia remains to be determined.…”

Section: Does Gender Affect the Astrocyte Response To Brain Injury?mentioning

confidence: 99%

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

Pekny

Pekna

2014

Physiological Reviews

740

576

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Astrocytes are the most abundant cells in the central nervous system (CNS) that provide nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis maintaining functions. During the past two decades, astrocytes emerged also as increasingly important regulators of neuronal functions including the generation of new nerve cells and structural as well as functional synapse remodeling. Reactive gliosis or reactive astrogliosis is a term coined for the morphological and functional changes seen in astroglial cells/astrocytes responding to CNS injury and other neurological diseases. Whereas this defensive reaction of astrocytes is conceivably aimed at handling the acute stress, limiting tissue damage, and restoring homeostasis, it may also inhibit adaptive neural plasticity mechanisms underlying recovery of function. Understanding the multifaceted roles of astrocytes in the healthy and diseased CNS will undoubtedly contribute to the development of treatment strategies that will, in a context-dependent manner and at appropriate time points, modulate reactive astrogliosis to promote brain repair and reduce the neurological impairment.

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Sex differences in Parkinson’s disease

Cited by 97 publications

References 24 publications

Gender Differences of Nonmotor Symptoms Affecting Quality of Life in Parkinson Disease

Gender Differences of Nonmotor Symptoms Affecting Quality of Life in Parkinson Disease

Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

Astrocyte Reactivity and Reactive Astrogliosis: Costs and Benefits

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