Sex Differences in Patients With Acute Decompensated Heart Failure

AlFaleh, Hussam; Thalib, Lukman; Kashour, Tarek; Hersi, Ahmad; Mimish, Layth; Elasfar, Abdelfatah; Almasood, Ali; Ghamdi, Saleh Al; Ghabashi, Abdullah; Malik, Asif; Hussein, Gamal; Al-Murayeh, Mushabab; Abuosa, Ahmed; Habeeb, Waleed Al; Habib, K F Al

doi:10.1177/0003319715607298

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…On discharge, men had a higher use of ACE-Is (62.8% vs. 53.4%; p < 0.001), beta-blockers (85.8% vs. 79.3%; p < 0.001), and aldosterone inhibitors (42.1% vs. 30.9%; p < 0.001) compared with women. Apart from higher atrial fibrillation (AF) in women (8.4% vs. 4.7% in men; p < 0.001) and higher ventricular arrhythmias in men (4.8% vs. 3% in women; p = 0.029), no differences were observed in hospital outcomes [6].…”

Section: Introductionmentioning

confidence: 99%

Saudi Heart Association (SHA) guidelines for the management of heart failure

AlHabeeb

AlAyoubi

Alghalayini

et al. 2019

Journal of the Saudi Heart Association

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Heart failure (HF) is the leading cause of morbidity and mortality worldwide and negatively impacts quality of life, healthcare costs, and longevity. Although data on HF in the Arab population are scarce, recently developed regional registries are a step forward to evaluating the quality of current patient care and providing an overview of the clinical picture. Despite the burden of HF in Saudi Arabia, there are currently no standardized protocols or guidelines for the management of patients with acute or chronic heart failure. Therefore, the Heart Failure Expert Committee, comprising 13 local specialists representing both public and private sectors, has developed guidelines to address the needs and challenges for the diagnosis and treatment of HF in Saudi Arabia. The ultimate aim of these guidelines is to assist healthcare professionals in delivering optimal care and standardized clinical practice across Saudi Arabia.

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Section: Introductionmentioning

confidence: 99%

Saudi Heart Association (SHA) guidelines for the management of heart failure

AlHabeeb

AlAyoubi

Alghalayini

et al. 2019

Journal of the Saudi Heart Association

Self Cite

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“…Male gender was also an independent risk factor for all-cause mortality. A study conducted in Saudi Arabia found no significant difference in survival between women and men [ 12 ]. Our findings were reported in a recent UK study in which women had a 14% age‐adjusted lower risk of all‐cause mortality [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Predictors of mortality in heart failure patients with reduced or mildly reduced Ejection Fraction: The CASABLANCA HF Study

Couissi,

Haboub,

Hamady

et al. 2024

Egypt Heart J

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Background Heart failure (HF) poses a significant public health challenge throughout the world and Morocco. Our objective was to delineate the epidemiological characteristics of Moroccan patients living with chronic heart failure and to identify prognostic factors correlated with CHF mortality. Results A total of 1344 patients participated in this study, with survival rates at 3, 6, and 10 years recorded at 75.2%, 60%, and 34%, respectively. During the follow-up, 886 patients succumbed, representing a mortality rate of 65.9%. A Cox regression model, utilizing baseline candidate variables, was developed to predict cardiovascular (CV) mortality. Predictors all of which had a P value less than 0.05 included age, left ventricular ejection fraction (EF) at commencement (< 35%), hypertension, male sex, anemia, creatinine levels, and the number of hospitalizations due to HF decompensation. Notably, the frequency of hospitalizations emerged as the most potent predictor of mortality, with an HR of 2.5 (95% CI [2–2.9]). Almost 90% of patients with three or more readmissions for HF decompensation experienced mortality by the follow-up’s conclusion. Conclusions This study offers valuable insights into risk factors and clinical outcomes in HF patients in Morocco. Factors such as male gender, advanced age, a history of hypertension, lower systolic blood pressure, rehospitalizations for HF decompensation, low left ventricular ejection fraction, anemia, and elevated creatinine levels were associated with increased mortality. Medical and health services managers should be aware of the substantial burden and future challenges posed by HF in Morocco, prompting the adoption of multidisciplinary strategies for its management and care.

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“…It is also worth to note that, like coronary artery disease and atrial fibrillation, RHD may have sex differences in etiology, presentation, co-morbidities, management and outcome[20–23]. Previous studies have reported the sex-dependent difference in disease prevalence, risk factor, progression and therapeutic outcome in RHD[7–9]. However, no study has been dedicated to investigate a potential sex difference in aortic valve pathology in RHD.…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent aortic valve pathology in patients with rheumatic heart disease

et al. 2017

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BackgroundRheumatic heart disease is an autoimmune disease caused by group A streptococci infection and frequently affects the aortic valve. Sex differences are common in the disease progression, treatment, and outcome. However, little is known about the sex differences in the pathology of aortic valves in rheumatic heart disease.DesignWe studied the end-stage calcific aortic valves from male versus female patients to reveal the sex-dependent pathology differences and molecular changes associated with requiring valve replacement.MethodsAortic valves from 39 patients with rheumatic heart disease (19 males and 20 females) were collected at the time of aortic valve replacement for comparative pathology, immunohistochemistry, and gene expression analyses. Clinical characteristics were also analyzed and compared between the two groups.ResultsAortic valves from female patients exhibited increased expression of collagens, infiltration of monocytes/macrophages and neovascularization. Aortic valves from female patients also had increased expression of inflammatory genes involved in the NFKB pathway (phosphorylated NFKB p65 subunit, IL8, and NOS3) and Th1 cytokine genes (IFNA and IL12B). The severe valve pathology in female patients was correlated with a higher serum level of anti-streptolysin O antibodies.ConclusionInflammation is more prominent in aortic valves of female patients with rheumatic heart disease. This sex difference may contribute to the severe valve pathology and worse outcome of female patients.

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Sex Differences in Patients With Acute Decompensated Heart Failure

Cited by 8 publications

References 34 publications

Saudi Heart Association (SHA) guidelines for the management of heart failure

Saudi Heart Association (SHA) guidelines for the management of heart failure

Predictors of mortality in heart failure patients with reduced or mildly reduced Ejection Fraction: The CASABLANCA HF Study

Sex-dependent aortic valve pathology in patients with rheumatic heart disease

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