2024
DOI: 10.1042/cs20231572
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Sex differences in physiological response to increased neuronal excitability in a knockin mouse model of pediatric epilepsy

Michael F. Hammer,
Collin T. Krzyzaniak,
Erfan Bahramnejad
et al.

Abstract: Epilepsy is a common neurological disease; however, few if any of the currently marketed antiseizure medications prevent or cure epilepsy. Discovery of pathological processes in the early stages of epileptogenesis has been challenging given the common use of preclinical models that induce seizures in physiologically normal animals. Moreover, despite known sex dimorphism in neurological diseases, females are rarely included in preclinical epilepsy models. We characterized sex differences in mice carrying a path… Show more

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