Sex differences in preclinical models of hypertension

Olivera, Sol; Graham, Delyth

doi:10.1038/s41371-022-00770-1

Cited by 10 publications

(2 citation statements)

References 97 publications

(153 reference statements)

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“…Male SHRs had higher BP compared to female SHRs at 20 weeks of age. This observation is consistent with the previous literature showing that male SHRs have higher BP than their female counterparts [ 17 , 18 ]. Other models of hypertension, such as Dahl salt-sensitive hypertension and deoxy corticosterone sensitive hypertension, also exhibit sex-specific differences in BP [ 17 , 19 ].…”

Section: Discussionsupporting

confidence: 94%

Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats

Raj

Sayfee

et al. 2023

Nutrients

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Oats are considered a functional food due to the beneficial health effects associated with their consumption and are suitable to be explored for their ability to prevent or manage chronic disease, such as hypertension. Here, we examined the cardiovascular benefits of an oat beta-glucan extract in male and female spontaneously hypertensive rats (SHRs) to unravel its sex-specific roles when used with an anti-hypertensive medication, hydrochlorothiazide. Five-week-old male and female SHRs and Wistar–Kyoto (WKY) rats were treated with oat beta-glucan and hydrochlorothiazide for 15 weeks. Twenty-week-old male and female SHRs showed high blood pressure (BP), cardiac remodeling, and cardiac dysfunction. These animals also had significantly increased levels of malondialdehyde (MDA), angiotensin II, and norepinephrine. Treatments with beta-glucan and hydrochlorothiazide were able to differentially prevent high BP, cardiac dysfunction, and alterations in malondialdehyde (MDA), angiotensin II, and norepinephrine in 20-week-old male and female SHRs. To conclude, beta-glucan alone and in combination with hydrochlorothiazide may be a promising a strategy for managing hypertension and related cardiac complications.

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Section: Discussionsupporting

confidence: 94%

Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats

Raj

Sayfee

et al. 2023

Nutrients

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show abstract

“…When compared to NC and PC, FRiST50 and FRaST50 significantly reduced body weight, confirming prior findings. The use of male rats in our experiment is significant because hypertension is linked with the renin-angiotensin-aldosterone system (RAAS), and it is evident that renal sympathetic nerve activity is less excitable and more easily repressed in females than males [47,48].…”

Section: Discussionmentioning

confidence: 99%

Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand–Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation

Akter,

Bulbul,

Sama-ae

et al. 2023

Nutrients

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This research investigated the antihypertensive effects of tamarind products and compared their potentials based on an animal model’s data verified by molecular docking, multitarget interactions, and dynamic simulation assays. GC-MS-characterized tamarind products were administered to cholesterol-induced hypertensive albino rat models. The two-week-intervened animals were dissected to collect their serum and organs and respectively subjected to analyses of their hypertension-linked markers and tissue architectures. The lead biometabolites of tamarinds interacted with eight target receptors in the molecular docking and dynamic simulation studies and with multitarget in the network pharmacological analyses. The results show that the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), C-reactive protein (CRP), troponin I, and lipid profiles were maximally reinstated by the phenolic-enriched ripened sour tamarind extract compared to the sweet one, but the seed extracts had a smaller influence. Among the tamarind’s biometabolites, ϒ-sitosterol was found to be the best ligand to interact with the guanylate cyclase receptor, displaying the best drug-likeliness with the highest binding energy, −9.3 Kcal. A multitargeted interaction-based degree algorithm and a phylogenetic tree of pathways showed that the NR3C1, REN, PPARG, and CYP11B1 hub genes were consistently modulated by ϒ-sitosterol to reduce hypertension and related risk factors. The dynamic simulation study showed that the P-RMSD values of ϒ-sitosterol–guanylate cyclase were stable between 75.00 and 100.00 ns at the binding pocket. The findings demonstrate that ripened sour tamarind extract may be a prospective antihypertensive nutraceutical or supplement target affirmed through advanced preclinical and clinical studies.

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Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats

Zhang,

Sheikh,

Tabassum

et al. 2024

GeroScience

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Sex differences in preclinical models of hypertension

Cited by 10 publications

References 97 publications

Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats

Oat Beta-Glucan Alone and in Combination with Hydrochlorothiazide Lowers High Blood Pressure in Male but Not Female Spontaneously Hypertensive Rats

Sour Tamarind Is More Antihypertensive than the Sweeter One, as Evidenced by In Vivo Biochemical Indexes, Ligand–Protein Interactions, Multitarget Interactions, and Molecular Dynamic Simulation

Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats

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