Sex differences in refeeding among hospitalized adolescents and young adults with eating disorders

Nagata, Jason M.; Bojorquez-Ramirez, Paola; Nguyen, Anthony; Ganson, Kyle T.; Machen, Vanessa I.; Cattle, Chloe J; Buckelew, Sara M.; Garber, Andrea K.

doi:10.1002/eat.23660

Cited by 17 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present findings add to an emerging yet, overall, still sparse body of studies that systematically compare treatment outcomes between men and women with EDs. Consistent with adolescent [ 45 , 46 ] and adult AN samples [ 51 ], we observed improved weight gains in men compared to women with AN throughout treatment. Although there were no significant gender differences when comparing age- and gender-standardized BMIs at admission to end-of-treatment, men showed more pronounced weight increases after the first week of treatment.…”

Section: Discussionsupporting

confidence: 86%

“…Among adolescent patients with EDs admitted to inpatient treatment, Coelho et al [ 45 ] found more favorable outcomes for 20 adolescent males (14 AN, 6 other) compared to 20 females (12 AN, 1 BN, 7 other) in terms of ED-related cognitions. Nagata et al [ 46 ] observed greater weight change among 95 hospitalized adolescent males (58 AN, 1 BN, 36 other) compared to 493 females (363 AN, 8 BN, 1 BED, 121 other), but also that male adolescents required a longer length of stay than females. However, Gorrell et al [ 47 ] compared gender differences in treatment response using baseline and end-of-treatment data from two clinical trials with adolescent patients with AN (24 male, 204 female) and found no significant gender differences for either weight gains or changes in ED-related cognitions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gender Differences in Treatment Outcomes for Eating Disorders: A Case-Matched, Retrospective Pre–Post Comparison

et al. 2022

View full text Add to dashboard Cite

Eating disorders (EDs) are increasingly emerging as a health risk in men, yet men remain underrepresented in ED research, including interventional trials. This underrepresentation of men may have facilitated the development of women-centered ED treatments that result in suboptimal outcomes for men. The present study retrospectively compared pre- vs. post-treatment outcomes between age-, diagnosis-, and length-of-treatment-matched samples of n = 200 men and n = 200 women with Anorexia Nervosa (AN), Bulimia Nervosa (BN), Binge Eating Disorder (BED), or Eating Disorder Not Otherwise Specified (EDNOS), treated in the same setting during the same period, and using the same measurements. Compared to women, men with AN showed marked improvements in weight gains during treatment as well as in ED-specific cognitions and general psychopathology. Likewise, men with BED showed marked weight loss during treatment compared to women with BED; ED-specific cognitions and general psychopathology outcomes were comparable in this case. For BN and EDNOS, weight, ED-specific cognitions, and general psychopathology outcomes remained largely comparable between men and women. Implications for treatments are discussed.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Gender Differences in Treatment Outcomes for Eating Disorders: A Case-Matched, Retrospective Pre–Post Comparison

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Although a minority of patients (7.8%) were initially diagnosed using DSM-IV criteria (prior to May 2013), we reviewed their clinical and psychosocial characteristics and recategorized them using DSM-5 criteria. For instance, we reviewed the charts of participants with a DSM-IV diagnosis of Eating Disorder Not Otherwise Specified (EDNOS) and reclassified them into an appropriate DSM-5 eating disorder diagnosis [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Sex differences and associations between zinc deficiency and anemia among hospitalized adolescents and young adults with eating disorders

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose To determine sex differences in and associations between zinc deficiency and anemia among adolescents and young adults hospitalized for medical complications of eating disorders. Methods We retrospectively reviewed electronic medical records of 601 patients aged 9–25 years admitted to the University of California, San Francisco Eating Disorders Program for medical instability, between May 2012 and August 2020. Descriptive statistics, crude, and adjusted logistic regression models were used to assess the association between zinc deficiency (< 55 mcg/dL) and anemia (< 13.6 g/dL in males [M] and < 11.8 g/dL in females [F]). Results A total of 87 males and 450 females met eligibility criteria (age 15.98 ± 2.81, 59.4% anorexia nervosa; admission body mass index 17.49 ± 2.82). In unadjusted comparisons, plasma zinc in males and females were not statistically different (M 64.88 ± 14.89 mcg/dL vs F 63.81 ± 13.96 mcg/dL, p = 0.517); moreover, there were no differences in the percentage of males and females with zinc deficiency (M 24.14% vs F 24.89%). However, a greater percentage of males than females were anemic (M 50.00% vs F 17.61%, p < 0.001), with similar findings in the subgroup with anorexia nervosa. In logistic regression models stratified by sex and eating disorder diagnosis, zinc deficiency was significantly associated with anemia in males (AOR 3.43, 95% CI 1.16, 10.13), but not females (AOR 1.47, 95% CI 0.86, 2.54). Conclusions For the first time, we demonstrate that zinc deficiency is equally severe in males compared to females hospitalized with medical complications from eating disorders, with nearly a quarter of inpatients experiencing zinc deficiency. Anemia is more common in males than females hospitalized with eating disorders. Level of evidence Level V: descriptive cross-sectional study.

show abstract

“…Per inpatient protocols, sociodemographic data, anthropometric measurements, disease characteristics, and lab data were documented in the EMR for each participant [ 29 , 30 ]. Clinical assessments in the EMR were retrospectively reviewed and entered into the UCSF Eating Disorders Program Medical Database.…”

Section: Methodsmentioning

confidence: 99%

Assessment of vitamin D among male adolescents and young adults hospitalized with eating disorders

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose Medical complications of eating disorders in males are understudied compared to females, as is the case of vitamin D deficiency. The aim of this study was to assess vitamin D levels among male and female adolescents and young adults hospitalized for medical complications of eating disorders. Methods We retrospectively reviewed electronic medical records of patients aged 9–25 years (N = 565) admitted to the University of California, San Francisco Eating Disorders Program for medical instability, between May 2012 and August 2020. Serum vitamin D (25-hydroxy) level was assessed at admission as was history of prior calcium, vitamin D, or multivitamin supplementation. Linear regression was used to assess factors associated with vitamin D levels. Results A total of 93 males and 472 females met eligibility criteria (age 15.5 ± 2.8, 58.8% anorexia nervosa; admission body mass index 17.6 ± 2.91). Among male participants, 44.1% had 25-hydroxyvitamin D levels < 30 ng/mL, 18.3% had 25-hydroxyvitamin D levels < 20 ng/mL, and 8.6% had 25-hydroxyvitamin D levels < 12 ng/mL. There were no significant differences in 25-hydroxyvitamin D levels in males compared to females, except that a lower proportion (1.9%) of female participants had 25-hydroxyvitamin D levels < 12 ng/mL (p = 0.001). Only 3.2% of males reported calcium or vitamin D-specific supplementation prior to hospital admission, while 8.6% reported taking multivitamins. White race, prior calcium/vitamin D supplementation, and higher calcium levels were associated with higher vitamin D levels on admission. Conclusions Nearly half of patients admitted to the hospital for malnutrition secondary to eating disorders presented with low 25-hydroxyvitamin D levels; males were more likely than females to have severe vitamin D deficiency. These findings support vitamin D assessment as part of the routine medical/nutritional evaluation for hospitalized eating disorder patients, with particular attention on male populations.

show abstract

Sex differences in refeeding among hospitalized adolescents and young adults with eating disorders

Cited by 17 publications

References 28 publications

Gender Differences in Treatment Outcomes for Eating Disorders: A Case-Matched, Retrospective Pre–Post Comparison

Gender Differences in Treatment Outcomes for Eating Disorders: A Case-Matched, Retrospective Pre–Post Comparison

Sex differences and associations between zinc deficiency and anemia among hospitalized adolescents and young adults with eating disorders

Assessment of vitamin D among male adolescents and young adults hospitalized with eating disorders

Contact Info

Product

Resources

About