Sex differences in schizophrenia relevant to clinical care

Seeman, Mary V.

doi:10.1080/14737175.2021.1898947

Cited by 42 publications

(32 citation statements)

References 133 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…58 Moreover, females tend to transition to psychosis later than males. 59 Second, Ms. Q's neurodevelopmental difficulties resolved with remediation, and she became an A and B student, as well as a varsity athlete. This type of improvement implies an associated cognitive improvement that would be unusual and unlikely for an adolescent on a pathway to psychosis.…”

Section: Neuropsychiatric Systemic Lupus Erythematosus In An Adolesce...mentioning

confidence: 99%

From the Blood-Brain Barrier to Childhood Development: A Case of Acute-Onset Psychosis and Cognitive Impairment Attributed to Systemic Lupus Erythematosus in an Adolescent Female

Johnson¹,

Sathappan²,

Hanly³

et al. 2022

Harv Rev Psychiatry

View full text Add to dashboard Cite

show abstract

Section: Neuropsychiatric Systemic Lupus Erythematosus In An Adolesce...mentioning

confidence: 99%

From the Blood-Brain Barrier to Childhood Development: A Case of Acute-Onset Psychosis and Cognitive Impairment Attributed to Systemic Lupus Erythematosus in an Adolescent Female

Johnson¹,

Sathappan²,

Hanly³

et al. 2022

Harv Rev Psychiatry

View full text Add to dashboard Cite

show abstract

“…Women are at a higher risk for metabolic and endocrine-induced side effects of antipsychotic drugs. This seems to be partly due to sex-specific pharmacokinetics (higher concentrations of free drug in target sites), enhancement of dopamine blockade by estrogen hormones, longer storage of antipsychotic drugs (due to the greater proportion of adipose tissue in women's bodies), and higher risk of drug-drug interactions (because of women's greater likelihood to being treated for comorbid illnesses) [18].…”

Section: Discussionmentioning

confidence: 99%

“…Taken together, these studies point to differential characteristics of male and female brains right from the beginning of psychosis [14], thus to differential response to pharmacotherapy [15]. Therefore, reconsidering the evidence, the need for personalized, gender-related care emerges; this is stressed by recent studies [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…There is a growing interest in current research focusing on several characteristics of psychotic illness separately analyzed in male and female populations. Subtle differences have been reported in many areas, with considerable implications for treatment [18]. Women may be disadvantaged as concerns access and quality of care for psychosis due to several factors, among which the fact that the emergence of psychosis is brought to clinical attention earlier for men than for women.…”

Section: Introductionmentioning

confidence: 99%

“…In people at high-risk of psychosis, differences between men and women in the expression of illness extend across a continuum, from the subclinical forms of illness to the debut of psychosis [14]. There are many special issues for women affected by psychosis that deserve particular attention, from sexuality (in terms of relationships, contraception, sexually transmitted diseases or sexual victimization) to the peripartum period (pregnancy, childbirth, postpartum period), from prescription of antipsychotic drugs to parenting (women with psychosis become parents much more frequently than men) and menopause [18].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Psychosis in Women: Time for Personalized Treatment

Mazza

Caroppo

Berardis

et al. 2021

JPM

View full text Add to dashboard Cite

Early detection and prompt treatment of psychosis is of the utmost importance. The great variability in clinical onset, illness course, and response to pharmacological and psychosocial treatment is in great part gender-related. Our aim has been to review narratively the literature focusing on gender related differences in the psychoses, i.e., schizophrenia spectrum disorders. We searched the PubMed/Medline, Scopus, Embase, and ScienceDirect databases on 31 July 2021, focusing on recent research regarding sex differences in early psychosis. Although women, compared to men, tend to have better overall functioning at psychotic symptom onset, they often present with more mood symptoms, may undergo misdiagnosis and delay in treatment and are at a higher risk for antipsychotic drug-induced metabolic and endocrine-induced side effects. Furthermore, women with schizophrenia spectrum disorders have more than double the odds of having physical comorbidities than men. Tailored treatment plans delivered by healthcare services should consider gender differences in patients with a diagnosis of psychosis, with a particular attention to early phases of disease in the context of the staging model of psychosis onset.

show abstract

Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk‐Locus Xq28,distal

Claus,

Sivalingam,

Koller

et al. 2024

American J of Med Genetics Pt B

View full text Add to dashboard Cite

Duplications of the Xq28,distal locus have been described in male and female patients with schizophrenia (SCZ) or intellectual disability. The Xq28,distal locus spans eight protein‐coding genes (F8, CMC4, MTCP1, BRCC3, VBP1, FUNDC2, CLIC2, and RAB39B) and is flanked by recurrent genomic breakpoints. Thus, the issue of which gene/s at this locus is/are relevant in terms of SCZ pathogenesis remains unclear. The aim of this study was to investigate the contribution of rare and potentially functionally relevant sequence variants within the Xq28,distal locus to SCZ risk using the single‐molecule molecular inversion probes (smMIP) method. Targeted sequencing was performed in a cohort of 1935 patients with SCZ and 1905 controls of European ancestry. The consecutive statistical analysis addressed two main areas. On the level of the individual variants, allele counts in the patient and control cohort were systematically compared with a Fisher's exact test: (i) for the entire present study cohort; (ii) for patients and controls separated by sex; and (iii) in combination with data published by the Schizophrenia Exome Meta‐Analysis (SCHEMA) consortium. On the gene‐wise level, a burden analysis was performed using the X‐chromosomal model of the Optimal Unified Sequence Kernel Association Test (SKAT‐O), with adjustment for possible sex‐specific effects. Targeted sequencing identified a total of 13 rare and potentially functional variants in four patients and 11 controls. However, neither at the level of individual rare and potentially functional variants nor at the level of the eight protein‐coding genes at the Xq28,distal locus was a statistically significant enrichment in patients compared to controls observed. Although inconclusive, the present findings represent a step toward improved understanding of the contribution of X‐chromosomal risk factors in neuropsychiatric disorder development, which is an underrepresented aspect of genetic studies in this field.

show abstract

Sex differences in schizophrenia relevant to clinical care

Cited by 42 publications

References 133 publications

From the Blood-Brain Barrier to Childhood Development: A Case of Acute-Onset Psychosis and Cognitive Impairment Attributed to Systemic Lupus Erythematosus in an Adolescent Female

From the Blood-Brain Barrier to Childhood Development: A Case of Acute-Onset Psychosis and Cognitive Impairment Attributed to Systemic Lupus Erythematosus in an Adolescent Female

Psychosis in Women: Time for Personalized Treatment

Contribution of Rare and Potentially Functionally Relevant Sequence Variants in Schizophrenia Risk‐Locus Xq28,distal

Contact Info

Product

Resources

About