Sex differences in subjective and objective responses to a stimulant medication (methylphenidate): Comparisons between overweight/obese adults with and without binge‐eating disorder

Davis, Caroline; Levitan, Robert D.; Kaplan, Allan S.; Carter-Major, Jacqueline C.; Kennedy, James L.

doi:10.1002/eat.22493

Cited by 21 publications

(12 citation statements)

References 37 publications

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“…Similarly, it has been previously suggested that ADHD and addiction-like eating share common mechanisms [23,24] and, therefore, that pharmacological treatment of ADHD may decrease overeating and facilitate weight loss in obese individuals [23,24,35]. However, recent findings about the immediate effects of a single dose of stimulant medication on food intake as a function of addiction-like eating have been inconclusive [36,37]. Thus, future research about possible effects and their mechanisms of pharmacological or non-pharmacological ADHD treatments on eating behavior and body weight is necessary.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Attentional and motor impulsivity interactively predict ‘food addiction’ in obese individuals

Meule

Zwaan

Müller

2017

Comprehensive Psychiatry

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Results support previous findings showing that non-planning impulsivity does not appear to play a role in eating-related self-regulation. Furthermore, this is the first study that shows interactive effects between different impulsivity facets when predicting 'food addiction' in obese individuals. Self-regulatory failure in eating-regulation (e.g., addiction-like overeating) may particularly emerge when both attentional and motor impulsivity levels are elevated.

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Section: Accepted M Manuscriptmentioning

confidence: 99%

Attentional and motor impulsivity interactively predict ‘food addiction’ in obese individuals

Meule

Zwaan

Müller

2017

Comprehensive Psychiatry

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“…Among the women, a significantly greater reduction from the placebo was observed in measures of appetite and food cravings. While the two conditions showed similar outcomes in any of the food-related variables among men [108]. In a 12-week randomized study, the effectiveness of methylphenidate versus CBT has recently been evaluated in BED treatment.…”

Section: Attention Deficit Hyperactivity Disorder (Adhd) Medicationsmentioning

confidence: 99%

Binge Eating Disorders; Updated and Emerging Approaches

et al. 2021

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Objective: Binge eating disorders (BED) recently become a global health care issue for clinicians with detrimental effects on all organ systems. A multidisciplinary strategy including pharmacotherapy is required for its management. Methods: This review is intended to comparatively evaluate the relative efficacy of different pharmacological agents in BED treatment with new therapeutic approaches, focusing on the clinical evidence and on Phase III randomized controlled trials. Results: Data suggest that certain treatments have advantages over placebos to reduce binge eating features; however, the small duration of such research with the lack of adequately sized trials was the major limitation in interpreting these findings. Furthermore, these medications are mostly not greatly efficient for BED associated with obesity except for topiramate, which markedly improves the features of binge episodes with weight loss. Till now, lisdexamfetamine is still the only drug with regulatory permission for BED therapy; however, its weight loss efficacy has not been established. Conclusion: Drugs alone or in combination approaches may be useful pharmacotherapies to yield promising outcomes acutely and over longer-term follow-up in the treatment of BED.

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“…However, in ADHD studies with both subjective and objective eating disorder examination instruments, consistent results are lacking, although it should be noted that the effects of long-term methylphenidate (MPH) on both appetite and weight have been minimally studied. A recently published, double-blind, drug-placebo, cross-over design trial found improvements, using MPH compared to placebo, in rates of binge eating cessation (8).…”

Section: Introductionmentioning

confidence: 99%

The effects of stimulants on eating patterns in children and adolescents with Attention Deficit Hyperactivity Disorder

Turan¹,

Akay²

2019

JMMS

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Objectives. This study aims to evaluate the effects of methylphenidate (MPH) on eating patterns and body mass index (BMI) in children with attention deficit/hyperactivity disorder (ADHD). The secondary aim of this study is the comparison between weight and eating behavior of children with ADHD undergoing an MPH treatment, and of children without ADHD. Methods. One hundred fourty three children and adolescents who diagnosed with ADHD were enrolled, and the effects of MPH on the eating patterns and BMI were evaluated. All participants completed a number of tests to analyze eating patterns and clinical psychopathological profiles. Results. Children and adolescents with ADHD had significantly higher scores on the EDE-Qeating concern, EDE-Q-shape concern, and all CPRS-RSF subscales than individuals without ADHD (p < .05). MPH treatment was associated with a notional reduction in height-sds and weight-sds. The results of the correlation analysis which assessed the possible contribution of the different treatment-related factors revealed no significant correlations between MPH mean dose [mg/(kg/d)], the duration of use (months), and the core characteristics of eating disorders except the restraint subscale of EDE Q. Conclusions. Our findings add to the growing research suggesting that MPH may be associated with disordered eating behaviors. Although the literature is limited, our findings conclude that MPH may not be associated with the reduction of growth velocity and disordered eating behaviors.

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Sex differences in subjective and objective responses to a stimulant medication (methylphenidate): Comparisons between overweight/obese adults with and without binge‐eating disorder

Abstract: These findings are relevant to the use of stimulant pharmacotherapy for BED, and raise the possibility that overweight/obese men may be relatively less responsive to this form of treatment. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:473-481).

Cited by 21 publications

References 37 publications

Attentional and motor impulsivity interactively predict ‘food addiction’ in obese individuals

Attentional and motor impulsivity interactively predict ‘food addiction’ in obese individuals

Binge Eating Disorders; Updated and Emerging Approaches

The effects of stimulants on eating patterns in children and adolescents with Attention Deficit Hyperactivity Disorder

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