Sex Differences in Survival Rates after Acute Myocardial Infarction

Marrugat, Jaume; Gil, Miguel; Sala, Joan

doi:10.1177/204748739900600205

Cited by 23 publications

(13 citation statements)

References 51 publications

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“…9 29Comparability of adjusted results is difficult because of the great heterogeneity in methodology, either in study design, inclusion criteria of the patients or in controlling for confounding factors 29 30 …”

Section: Discussionmentioning

confidence: 99%

Role of age and sex in short-term and long term mortality after a first Q wave myocardial infarction

Marrugat

2001

Journal of Epidemiology &Amp; Community Health

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Study objective-The objective of this study was to analyse whether the risk of death within 28 days and three years after a first Q wave myocardial infarction was higher in hospitalised women than in men. Design-Follow up study. Patients and setting-All consecutive first Q wave myocardial infarction patients aged 25 to 74 years (447 women and 2322 men) admitted to a tertiary hospital in Gerona, Spain, from 1978 to 1997 were registered and followed up for three years. Main results-Women were older, presented more comorbidity and developed more severe myocardial infarctions than men. A significant interaction was found between sex and age. Women aged 65-74 had higher early mortality risk than men of the same age (OR 1.62; 95% CI 1.01, 2.66) after adjusting for age, comorbidity and acute complications including heart failure. Women under 65 tended to be at lower risk of early mortality than men (0.45 (95% CI 0.19, 1.04). Three year mortality of 28 day survivors did not diVer between sexes. Conclusions-These data support the idea that the higher 28 day mortality in hospitalised women with a first Q wave myocardial infarction is mainly attributable to the large number of patients aged 65 to 74 years in whom the risk is higher than that in men. Women under 65 with myocardial infarction do not seem to be a special group of risk. (J Epidemiol Community Health 2001;55:487-493) Women hospitalised with an acute myocardial infarction (AMI) have higher short-term mortality rates than men.1 Such a diVerence is mostly explained by the greater age of women at the time of myocardial infarction.2 Other contributing factors are the increased prevalence of cardiovascular risk factors or comorbidity in women, a tendency toward the underuse of diagnostic procedures or therapeutic interventions in women compared with men.2 Some studies have, however, reported a significantly higher mortality in women after adjustment for some or all of these factors.3-8 Suggestions as to mechanisms that may be implicated in this excess risk for women have been speculative and remain unclear.9 10 A candidate factor is the higher frequency in women of clinical manifestations of left ventricular dysfunction (acute pulmonary oedema or cardiogenic shock) during the acute phase. Nevertheless, some studies have reported an increased risk of death or complications in women even after adjusting for such dissimilarities in heart failure variables. 3 11-14

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Section: Discussionmentioning

confidence: 99%

Role of age and sex in short-term and long term mortality after a first Q wave myocardial infarction

Marrugat

2001

Journal of Epidemiology &Amp; Community Health

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“…CHD mortality has declined in most developed countries over recent years, with greater declines for men than women (Peltonen, Lundberg, Huhtasaari & Asplund, 2000). Women have poorer prognosis than men following acute myocardial infarction, after adjusting for clinical covariates (Marrugat, Gil & Sala, 1999). These studies suggest a need for research on health care received by women first presenting with CHD symptoms.…”

Section: Socio-demographic Inequalities In Chdmentioning

confidence: 92%

Patient characteristics and inequalities in doctors’ diagnostic and management strategies relating to CHD: A video-simulation experiment

Arber

McKinlay

Adams

et al. 2006

Social Science & Medicine

153

133

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“…Several studies have addressed the issue of gender differences in the outcome of cardiovascular diseases (1)(2)(3). Few studies have dealt with gender differences and arrhythmias (4,5).…”

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confidence: 99%

Gender-Related Differences in Rhythm Control Treatment in Persistent Atrial Fibrillation

Rienstra

Veldhuisen²,

Hagens

et al. 2005

Journal of the American College of Cardiology

209

111

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Sex Differences in Survival Rates after Acute Myocardial Infarction

Cited by 23 publications

References 51 publications

Role of age and sex in short-term and long term mortality after a first Q wave myocardial infarction

Role of age and sex in short-term and long term mortality after a first Q wave myocardial infarction

Patient characteristics and inequalities in doctors’ diagnostic and management strategies relating to CHD: A video-simulation experiment

Gender-Related Differences in Rhythm Control Treatment in Persistent Atrial Fibrillation

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