Sex differences in the symptoms and psychological factors that influence quality of life in patients with irritable bowel syndrome

Tang, Yurong; Yang, Wei-Wei; Wang, Yilin; Lin, Lin

doi:10.1097/meg.0b013e328351b2c2

Cited by 77 publications

(73 citation statements)

References 34 publications

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“…This could be in line with some recent evidences demonstrating more severe IBS symptoms as well as negative impacts on patients' quality of life in cases with other neurologic and/or psychologic co-morbidities such as anxiety and depression 23,24. All of these findings are supporting the neurologic-related identity of IBS and more specifically the association between RLS and symptom severity in IBS patients, which could be linked to serotonin transmission shown to be involved in both conditions of IBS25 and RLS 26…”

Section: Discussionsupporting

confidence: 91%

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Borji¹,

Fereshtehnejad²,

Vakili³

et al. 2012

J Neurogastroenterol Motil

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Background/AimsAs a common gastrointestinal (GI) disorder, irritable bowel syndrome (IBS) has been reported to be associated with some psychological and neurological factors. This study aimed to evaluate the prevalence rate of restless legs syndrome (RLS) in a sample of IBS patients and to compare this prevalence with that of matched healthy controls.MethodsThis prospective comparative study was conducted in Tehran, Iran during 2010-2011. Based on the Rome III criteria, a total number of 225 definite IBS patients and 262 age- and sex-matched healthy controls were recruited in the final assessment to compare the prevalence rate of RLS between the 2 groups.ResultsRLS was significantly more frequent in IBS group (25.3% vs 6.5%, P < 0.001) which led to an odds ratio (OR) of 4.89 (95% CI, 2.75-8.70). IBS patients with co-morbid RLS significantly suffered more from stomach pain (96.5% vs 86.3%, OR = 4.36 [95% CI, 1.00-19.12]), nausea (40.4% vs 21.4%, OR = 2.48 [95% CI, 1.30-4.73]) and vomiting (10.5% vs 2.4%, OR = 4.82 [95% CI, 1.31-17.76]).ConclusionsBy enrolling a considerable number of IBS patients and healthy controls, our study showed a significantly higher prevalence of RLS in IBS patients. Surprisingly, a higher prevalence rate of RLS was also accompanied with a more severe discomfort and stomach pain in IBS patients. It seems that screening patients with IBS for RLS may lead to greater identification of RLS and improved treatment for both conditions.

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Section: Discussionsupporting

confidence: 91%

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Borji¹,

Fereshtehnejad²,

Vakili³

et al. 2012

J Neurogastroenterol Motil

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“…These differences were not due to differences in UCPPS symptom severity or age. Increased co-morbid pain symptoms have also been reported for women with IBS compared to men despite similar IBS severity and level of psychological symptoms [17, 18]. A recent study also found women with UCPPS are more likely to report bothersome non-urologic symptoms across multiple organ systems than men with UCPPS.…”

Section: Discussionmentioning

confidence: 97%

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Naliboff

Stephens

Afari

et al. 2015

Urology

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Objectives To determine the extent, severity and sex differences of psychosocial deficits in men and women with urologic chronic pelvic pain syndromes (UCPPS), which in the past have been considered separate bladder (Interstitial Cystitis/Painful Bladder Syndrome) and prostate (Chronic Prostatitis/Chronic Pelvic Pain Syndrome) disorders. Evaluations of men and women separately suggest UCPPS is associated with increased anxiety and depression. However, studies directly testing deficits in broader psychosocial domains such as cognitive processes, intimate relationships and trauma history, or tests of sex differences in the pattern of difficulties associated with UCPPS have not been performed. Methods A total of 233 female and 191 male UCPPS patients and 235 female and 182 male healthy controls (HCs) were recruited from six academic medical centers in the US and evaluated with a comprehensive battery of symptom, psychosocial, and illness impact measures. Primary comparisons of interest were between UCPPS patients and HC, and between men and women with UCPPS. Results In addition to greater negative affect, male and female UCPPS patients show higher levels of current and lifetime stress, poorer illness coping, increased self-report of cognitive deficits and more widespread pain symptoms compared to sex and education matched HC. Similar problems were found in male and female UCPPS although female UCPPS showed increased self-report of childhood adversity and more widespread symptoms of pain and discomfort. Conclusions Given the significance of psychosocial variables in prognosis and treatment of chronic pain conditions, the results add substantially to our understanding of the breath of difficulties associated with UCPPS and point to important areas for clinical assessment.

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“…24 The IBS-D subtype was also more prevalent in males, which was consistent with other epidemiological studies in Asia. [24][25][26] The highest medical costs in previous European studies were associated with older IBS patients, 24 which might be related to more frequent hospital admission of older patients. However, in the present study, medical costs, resource utilization and claims were highest for middle-aged patients 40-59 years, which is consistent with data from the US.…”

Section: Discussionmentioning

confidence: 99%

Estimating the Burden of Irritable Bowel Syndrome: Analysis of a Nationwide Korean Database

Jung¹,

Kim²,

Park³

et al. 2014

J Neurogastroenterol Motil

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Background/AimsManagement of irritable bowel syndrome (IBS) imposes a heavy economic burden. This study was to estimate the epidemiologic features of IBS and to report the IBS burden for the first time in the Korean population. MethodsA cross-sectional study was conducted using the National Health Insurance (NHI) system database, which covers the entire population of Korea. IBS was defined as diagnostic code -10 in adults with any outpatient clinic visits or hospitalization related to IBS. We excluded diseases that mimic IBS symptoms. ResultsA total of 2.42 million (58.2% female) individuals were identified as patients with IBS, yielding an age-and gender-adjusted prevalence of 5.1% in males and 6.9% in females. The prevalence of IBS increased proportionally with age, with higher medical costs in middle-aged patients. Outpatient clinics were visited by 98.6% of IBS patients, and 1.9% were treated upon admission. Of these patients, 87.6% were given a prescription. Co-morbidities that commonly accompanied IBS included upper gastrointestinal (36.1%), respiratory (12.3%), musculoskeletal (8.0%) disease, somatoform (4.3%) and depression/anxiety disorders (3.1%). The NHI costs of IBS, which include the NHI covered cost and beneficiary copayment charges, were estimated to be 155 million USD, which accounts for 0.46% of the total NHI costs for the entire Korean population. ConclusionsAccording to the Korean national claims database, about 6% of the Korean population seeks medical care for IBS at least once per year. This high prevalence places a large economic burden on the Korean healthcare system, accounting for 0.46% of overall national medical expenditure.

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Sex differences in the symptoms and psychological factors that influence quality of life in patients with irritable bowel syndrome

Abstract: There are significant gender differences in the symptoms, psychological rating, and QOL scores in IBS. Somatic symptoms, anxiety, and depression all contribute to the negative impact of IBS. Our findings suggest that gender differences should be recognized in IBS treatment.

Cited by 77 publications

References 34 publications

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group

Widespread Psychosocial Difficulties in Men and Women With Urologic Chronic Pelvic Pain Syndromes: Case-control Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network

Estimating the Burden of Irritable Bowel Syndrome: Analysis of a Nationwide Korean Database

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