Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients

Abstract

(1) Background: The aim of this study was to analyze the sex differences in the treatment of uveal melanoma (UM) in a group of 1336 patients from a national referral center during the period 2018–2021. (2) Materials and Methods: The study was designed in a retrospective manner. A total of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, Poland, between 1 January 2018 and 31 December 2021, were included in the study. The demographic and clinical data were compiled, including the sex of patients and the treatment methods. (3) Results: In total, 1336 patients with ocular melanoma were identified, including 726 women (54.34%) and 610 men (45.66%). A total of 49.70% of tumors were localized in the right eye and 50.30% in the left eye. UMs were localized statistically significantly more frequently posterior to the equator of the eye globe in men than in women (79.67% vs. 74.10%, Chi^2 Pearson test p = 0.035). Tumors tended to be larger in men, but this difference was not clinically significant. Men were enucleated more often than women (23.44% vs. 18.04%, Chi^2 Pearson test p = 0.015). (4) Conclusions: Statistically significant sex differences were found in the treatment of uveal melanoma in a national referral center in Poland, with men being enucleated more often than women.

Impact of the SARS-CoV-2 (COVID-19) Pandemic on Characteristics and Management of Uveal Melanoma in the National Referral Center in Poland

“…Our results were consistent with those from studies conducted in Spain and Ireland, where increased tumor size at diagnosis was found during the COVID-19 pandemic [17,19]. Additionally, the Irish study found that tumors tended to be larger in men both before and during the COVID-19 pandemic, which was consistent with the results of our previous study on sex differences in uveal mealanoma treatment in Poland in 2018-2021 [21]. A study in the UK also found that more patients presented with more advanced cancers postlockdown [18].…”

“…Recruitment methods for this study have been described in detail in our previous work [ 21 ]. Briefly, the study design was a retrospective case series.…”

Impact of SARS-CoV-2 (COVID-19) Pandemic on Characteristics and Management of Uveal Melanoma in National Referral Center in Poland

“…The recruitment methods for this study have been described in details in our previous paper [21]. In brief, the study design was a retrospective case series.…”