Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement

Vlastra, Wieneke; Chandrasekhar, Jaya; Blanco, Bruno García del; Tchétché, Didier; Brito, Fábio Sândoli de; Barbanti, Marco; Kornowski, Ran; Latib, Azeem; D’Onofrio, Augusto; Ribichini, Flavio; Baan, Jan; Tijssen, Jan G.P.; Moreno, Raúl; Dumonteil, Nicolas; Tarasoutchi, Flávio; Sartori, Samantha; D’Errigo, Paola; Tarantini, Giuseppe; Lunardi, Mattia; Orvin, Katia; Pagnesi, Matteo; Berenguer, Alberto; Modine, Thomas; Dangas, George; Mehran, Roxana; Piek, Jan J.; Delewi, Ronak

doi:10.1016/j.jacc.2019.09.015

Cited by 92 publications

(88 citation statements)

References 25 publications

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“…Additionally, smaller peripheral vessels in women were found responsible for a higher rate of vascular complications and major bleeding, which might, however, not entail worse outcomes due to the amenability to prompt vascular management [12][13][14]. Overall, women undergoing TAVR face equal 30-day outcomes, but superior long-term survival compared to men, irrespective of the selected access route ( [12][13][14][15]; Fig. 2).…”

Section: Aortic Stenosismentioning

confidence: 99%

Gender-specific differences in valvular heart disease

Nitsche

Koschutnik

Kammerlander

et al. 2020

Wien Klin Wochenschr

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The development of new devices and treatment options has greatly increased the interest in heart valve diseases. In this context, the consideration of gender differences in diagnosis, treatment success, and prognosis is of great importance. Available data show that women and men with heart valve disease have different risk profiles, which have a significant impact on treatment outcomes and prognosis. It is the purpose of this review article to give an overview of gender-related differences in patients with valvular heart disease, regarding clinical presentation, treatment, and outcomes. In light of the emerging treatment possibilities, future research should emphasize the role of gender since both sexes benefit from tailored management.

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Section: Aortic Stenosismentioning

confidence: 99%

Gender-specific differences in valvular heart disease

Nitsche

Koschutnik

Kammerlander

et al. 2020

Wien Klin Wochenschr

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“…Since TAVR became commercially available in the United States in 2011, women have been referred more often for TAVR compared to men [ 49 ]. Women are often older when they develop symptomatic AS, which may explain the increase in TAVR referral initially [ 51 ].…”

Section: Structural Interventionsmentioning

confidence: 99%

“…Post-procedurally, women have demonstrated increased risk of annular rupture, coronary obstruction, peripheral vascular complications, and possible risk of patient–prosthesis mismatch [ 52 ]. In contrast, the need for permanent pacemaker implantation post-TAVR was lower in women compared to men (Table 1 ) [ 51 ].…”

Section: Structural Interventionsmentioning

confidence: 99%

“…Permanent pacemaker implantation Permanent pacemaker placement is a known risk of TAVR, with risk related to valve type and underlying conduction disease. A 2019 study looking at sex differences in outcomes among the CENTER collaboration data for trans-femoral TAVR procedures noted that the need for permanent pacemaker implantation was lower for females compared to males (12.2 vs. 16.7%, RR 0.7, 95% CI 0.7–0.8%, p < 0.001) [ 51 ]. This difference was seen with both self-expandable and balloon-expandable valves, though pacemaker implantation rates were higher in both sexes among the self-expandable valve group [ 51 ].…”

Section: Structural Interventionsmentioning

confidence: 99%

“…A 2019 study looking at sex differences in outcomes among the CENTER collaboration data for trans-femoral TAVR procedures noted that the need for permanent pacemaker implantation was lower for females compared to males (12.2 vs. 16.7%, RR 0.7, 95% CI 0.7–0.8%, p < 0.001) [ 51 ]. This difference was seen with both self-expandable and balloon-expandable valves, though pacemaker implantation rates were higher in both sexes among the self-expandable valve group [ 51 ]. This finding may be due to anatomical and sizing discrepancies seen among the sexes, but warrants further investigation to characterize the mechanism.…”

Section: Structural Interventionsmentioning

confidence: 99%

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Sex-Based Differences in Coronary and Structural Percutaneous Interventions

et al. 2020

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In the current state of interventional cardiology, the ability to offer advanced therapies to patients who historically were not surgical candidates has grown exponentially in the last few decades. As therapies have expanded in complex coronary and structural interventions, the nuances of treating certain populations have emerged. In particular, the role of sex-based anatomic and outcome differences has been increasingly recognized. As guidelines for cardiovascular prevention and treatment for certain conditions may vary by sex, therapeutic interventions in the structural and percutaneous coronary areas may also vary. In this review, we aim to discuss these differences, the current literature available on these topics, and areas of focus for the future.

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Sex Differences in Procedural Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion

Darden

Duong

et al. 2021

JAMA Cardiol

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IMPORTANCE Left atrial appendage occlusion (LAAO) has emerged as an alternative to anticoagulation for select patients with atrial fibrillation; however, women have been underrepresented in clinical trials of LAAO, and sex-specific subanalyses are limited.OBJECTIVE To evaluate the sex differences in the baseline characteristics of patients undergoing LAAO implant and in the in-hospital outcomes after LAAO implant.

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Sex Differences in Transfemoral Transcatheter Aortic Valve Replacement

Cited by 92 publications

References 25 publications

Gender-specific differences in valvular heart disease

Gender-specific differences in valvular heart disease

Sex-Based Differences in Coronary and Structural Percutaneous Interventions

Sex Differences in Procedural Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion

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