Sex differences in vasopressin 1a receptor regulation of social communication within the lateral habenula and dorsal raphe of mice

Rigney, Nicole; Beaumont, Rachael; Petrulis, Aras

doi:10.1016/j.yhbeh.2020.104715

Cited by 28 publications

(23 citation statements)

References 106 publications

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“…Although AVP has been implicated in the production of vocalizations [7], few studies have identified the relevant neuroanatomical source of AVP or its locus of action. Recently, we found that blockade of V1aR in the lateral habenula reduced male courtship USVs in mice [9] but that BNST AVP-expressing cell deletion did not affect USVs [34]. Therefore, it is likely that AVP sources outside the PVN and the BNST, such as the MA, play the lead role in driving USV production.…”

Section: Discussionmentioning

confidence: 99%

“…The neuropeptide arginine-vasopressin (AVP; vasotocin in non-mammalian vertebrates) is an important modulator of vertebrate social behavior [1][2][3][4], including that of humans [5,6]. AVP acts on several receptors and in various brain regions to alter social communication [7][8][9], maternal care [10], pair bonding [11][12][13], cognition [14], and social recognition [15][16][17]. Studies involving blockade or stimulation of central vasopressin receptors and vasopressin knockout also implicate AVP in the generation of anxiety states and generally point at AVP acting as an anxiogenic neuromodulator [18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus

Rigney¹,

Whylings²,

Vries³

et al. 2020

Neuroendocrinology

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The neuropeptide arginine-vasopressin (AVP) has long been implicated in the regulation of social behavior and communication in diverse taxa, but the source of AVP release relevant for behavior has not been precisely determined. Potential sources include hypothalamic cell populations such as the paraventricular (PVN), supraoptic, and suprachiasmatic nuclei, as well as extrahypothalamic cell groups in the extended amygdala. To address if AVP-expressing cells in the PVN are important for mouse social communication, we deleted PVN AVP-expressing cells using viral-mediated delivery of Cre-dependent caspase-9 cell death construct into the PVN of AVP-Cre-positive mice (expressing Cre-recombinase under the control of the AVP promoter) or AVP-Cre-negative littermate controls, and assessed their levels of social investigation, social communication, anxiety, sex behavior, and aggressive behavior. We found that these lesions increased social investigation in females, but not in males. However, in males but not in females, these lesions increased non-social anxiety-related behaviors in the elevated-plus maze. These results therefore point at differential involvement of PVN AVP-expressing cells in the context of social and emotional behavior in the two sexes, which may contribute to sex differences in social communication and anxiety disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus

Rigney¹,

Whylings²,

Vries³

et al. 2020

Neuroendocrinology

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“…Notably, AVT has been associated with increased courtship behaviour, aggression and other rank-associated behaviours such as status signalling through urine [ 172 – 175 ]. AVP has been associated with similar social behaviours in mammals [ 176 – 178 ], suggesting that its functions are largely conserved and supporting a case for studying its role in social memory across species. Similarly, isotocin and mesotocin, the OT homologues found in fish and reptiles, respectively, appear to function like OT with respect to social approach, sexual behaviour and formation of partner bonds and parenting behaviour [ 179 – 181 ].…”

Section: Individual Social Memorymentioning

confidence: 99%

Neural systems that facilitate the representation of social rank

Dwortz

Curley

Tye

et al. 2022

Phil. Trans. R. Soc. B

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Across species, animals organize into social dominance hierarchies that serve to decrease aggression and facilitate survival of the group. Neuroscientists have adopted several model organisms to study dominance hierarchies in the laboratory setting, including fish, reptiles, rodents and primates. We review recent literature across species that sheds light onto how the brain represents social rank to guide socially appropriate behaviour within a dominance hierarchy. First, we discuss how the brain responds to social status signals. Then, we discuss social approach and avoidance learning mechanisms that we propose could drive rank-appropriate behaviour. Lastly, we discuss how the brain represents memories of individuals (social memory) and how this may support the maintenance of unique individual relationships within a social group. This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.

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“…Finally, it is worth considering a role for social cues in the regulation of this daily activity. The LHb is implicated in reward processing, and it is embedded within many pathways which regulate reward-based feeding (Stamatkis et al, 2016), drug seeking (Nair et al, 2021), and social behaviour (Valentinova et al, 2019;Rigney et al, 2020). It is possible that the LHb may receive feedback from the drivers of these behaviourswhich accordingly entrain neural activity.…”

Section: Intrinsic Regulation Of Lateral Habenula Circadian Activitymentioning

confidence: 99%

Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders

Young

Lyons

Piggins

2022

Front. Behav. Neurosci.

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The neural circadian system consists of the master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN) communicating time of day cues to the rest of the body including other brain areas that also rhythmically express circadian clock genes. Over the past 16 years, evidence has emerged to indicate that the habenula of the epithalamus is a candidate extra-SCN circadian oscillator. When isolated from the SCN, the habenula sustains rhythms in clock gene expression and neuronal activity, with the lateral habenula expressing more robust rhythms than the adjacent medial habenula. The lateral habenula is responsive to putative SCN output factors as well as light information conveyed to the perihabenula area. Neuronal activity in the lateral habenula is altered in depression and intriguingly disruptions in circadian rhythms can elevate risk of developing mental health disorders including depression. In this review, we will principally focus on how circadian and light signals affect the lateral habenula and evaluate the possibility that alteration in these influences contribute to mental health disorders.

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Sex differences in vasopressin 1a receptor regulation of social communication within the lateral habenula and dorsal raphe of mice

Cited by 28 publications

References 106 publications

Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus

Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus

Neural systems that facilitate the representation of social rank

Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders

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