2022
DOI: 10.3390/nu14102012
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Sex Differences in Vitamin D Status as a Risk Factor for Incidence of Disability in Instrumental Activities of Daily Living: Evidence from the ELSA Cohort Study

Abstract: Vitamin D deficiency compromises elements underlying the disability process; however, there is no evidence demonstrating the association between vitamin D deficiency and the incidence of disability in instrumental activities of daily living (IADL). We investigated the association between vitamin D deficiency and the risk of incidence of IADL disability separately in men and women. A total of 4768 individuals aged ≥50 years from the English Longitudinal Study of Aging (ELSA) and without IADL disability accordin… Show more

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“…Vitamin D (VitD) is renowned for its positive impact on musculoskeletal structure and functions, particularly in preventing falls, fragility fractures, impaired locomotion, and mobility disability among older adults with deficient plasma levels [ 6 ]. In the aging process, the decline in physical performance is recognized as the first phenotypical clinical feature of accelerated aging, preceding and contributing to the onset of muscle-skeletal chronic diseases and the burden of disability [ 7 , 8 , 9 ]. Consistently, aging is associated with a higher likelihood of vitamin D deficiency and dysregulated vitamin D function due to reduced sensitivity to 1,25(OH)2D3.…”
Section: Introductionmentioning
confidence: 99%
“…Vitamin D (VitD) is renowned for its positive impact on musculoskeletal structure and functions, particularly in preventing falls, fragility fractures, impaired locomotion, and mobility disability among older adults with deficient plasma levels [ 6 ]. In the aging process, the decline in physical performance is recognized as the first phenotypical clinical feature of accelerated aging, preceding and contributing to the onset of muscle-skeletal chronic diseases and the burden of disability [ 7 , 8 , 9 ]. Consistently, aging is associated with a higher likelihood of vitamin D deficiency and dysregulated vitamin D function due to reduced sensitivity to 1,25(OH)2D3.…”
Section: Introductionmentioning
confidence: 99%