Sex differences in volume and structural covariance of the anterior and posterior hippocampus

Persson, Jonas; Spreng, R. Nathan; Turner, Gary R.; Herlitz, Agneta; Morell, Arvid; Stening, Eva; Wahlund, Lars‐Olof; Wikström, Johan; Söderlund, Hedvig

doi:10.1016/j.neuroimage.2014.05.038

Cited by 77 publications

(65 citation statements)

References 75 publications

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“…Furthermore, hippocampal dysfunction is sexually dimorphic in several diseases including anxiety and dementia (Lebron-Milad et al, 2012; Murphy et al, 1996). Differences between anterior and posterior hippocampal function and anatomy have been identified in humans in a sex-dependent manner (Chua et al, 2007; Persson et al, 2014) but, again, inconsistencies in literature suggest that the specifics of these differences are not entirely clear (Goldstein et al, 2001; Ruigrok et al, 2014). Despite the variability in the characterization of sex differences in the hippocampus, it is clear differences exist.…”

Section: Discussionmentioning

confidence: 99%

In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice

et al. 2017

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Behaviorally relevant sex differences are often associated with structural differences in the brain and many diseases are sexually dimorphic in prevalence and progression. Characterizing sex differences is imperative to gaining a complete understanding of behavior and disease which will, in turn, allow for a balanced approach to scientific research and the development of therapies. In this study, we generated novel tissue probability maps (TPMs) based on 30 male and 30 female in vivo C57BL/6 mouse brain magnetic resonance images and used voxel-based morphometry (VBM) to analyze sex differences. Females displayed larger anterior hippocampus, basolateral amygdala, and lateral cerebellar cortex volumes, while males exhibited larger cerebral cortex, medial amygdala, and medial cerebellar cortex volumes. Atlas-based morphometry (ABM) revealed a statistically significant sex difference in cortical volume and no difference in whole cerebellar volume. This validated our VBM findings that showed a larger cerebral cortex in male mice and a pattern of dimorphism in the cerebellum where the lateral portion was larger in females and the medial portion was larger in males. These results are consonant with previous ex vivo studies examining sex differences, but also suggest further regions of interest.

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Section: Discussionmentioning

confidence: 99%

In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice

et al. 2017

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“…On the other hand, relative to brain size or intracranial volume, some studies find no significance sex difference in hippocampal volume (87,292,443,504). These equivocal results may, in part, stem from a failure to consider sexual dimorphisms within certain subregions of the hippocampus (484), or, and perhaps more likely, a failure to control for age, exercise, body mass index, and education as these all influence hippocampal volume (160,209,361,456,515,517,604). It should also be recognized that methodological differences among studies may contribute to differences in findings (322).…”

Section: Sex Differences In the Central Nervous Systemmentioning

confidence: 99%

“…The anterior and posterior hippocampi have different functional connectivity, leading to hypotheses that they are preferentially activated during different forms of encoding and retrieval (449,496). Persson et al (484) found that women specifically have larger posterior, but not anterior, hippocampi than men, and found that these regions may also have different structural connectivity between the sexes. Finally, other influences unique to the female physiology, such as menstrual cycle phase (503) and reproductive experience (44,47,479,480) may also contribute to differences in hippocampal volume in women, factors that are not always controlled for in studies.…”

Section: Sex Differences In the Central Nervous Systemmentioning

confidence: 99%

Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning

Hamson

Roes

Galea

2016

Comprehensive Physiology

173

110

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Sex differences in neurological disease exist in incidence, severity, progression, and symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in neuropsychiatric disease with men showing greater cognitive impairment in schizophrenia, but women showing more severe dementia and cognitive decline with Alzheimer's disease. Although there are no overall differences in intelligence between the sexes, men, and women demonstrate slight but consistent differences in a number of cognitive domains. These include a male advantage, on average, in some types of spatial abilities and a female advantage on some measures of verbal fluency and memory. Sex differences in traits or behaviors generally indicate the involvement of sex hormones, such as androgens and estrogens. We review the literature on whether adult levels of testosterone and estradiol influence spatial ability in both males and females from rodent models to humans. We also include information on estrogens and their ability to modulate verbal memory in men and women. Estrone and progestins are common components of hormone therapies, and we also review the existing literature concerning their effects on cognition. We also review the sex differences in the hippocampus and prefrontal cortex as they relate to cognitive performance in both rodents and humans. There has been greater recognition in the scientific literature that it is important to study both sexes and also to analyze study findings with sex as a variable. Only by examining these sex differences can we progress to finding treatments that will improve the cognitive health of both men and women. © 2016 American Physiological Society. Compr Physiol 6:1295-1337, 2016.

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“…12 Uniquely, hippocampusis is more connected with parietal lobe on male, and temporal lobe on female. 9 Androgen hormone is mentioned as one of the important factors affecting spatial ability. 3,[7][8] Androgen plays a role on hippocampus cell formation and development during prenatal period.…”

Section: -11mentioning

confidence: 99%

“…[3][4][5][6][7][8][9] These differences are still contradiction. Several studies had reported differences and other studies had reported no differences at all.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Spatial Ability Between Male and Female Athletes

Putri¹,

Lubis²,

Ong³

2017

amj

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Background: Spatial ability is the ability to understand and memorize spatial relationship beneficial objects. This domain of cognition is crucial in sport activity for deciding strategy. Sex is one of the factors that determine spatial ability. This study aimed to determine the comparison of spatial ability between male and female athletes. Methods: This cross-sectional study was conducted by non-pairing comparative method. Data were taken on September 2015 in Indonesian National Sport Committee (Komite Olahraga Nasional Indonesia, KONI) Sport Center, Bandung, West Java, Indonesia. Spatial instrument used was Spatial Ability Test 1. Subjects were recruited from athletes of KONI, West Java, aged between 19-27 years old who were being trained for 19th National Sports Weeks (Pekan Olahraga Nasional, PON XIX) 2016. Mean value between male and female were compared using studies T-test with significance value (p)<0.05. Results: The total samples were 95 subjects, consisting of 44 males and 51 females. Results of the mean value in male were 29.16 (± 3.48) and female 28.80 (± 3.74).By using studies T-test, the significance outcome found was p = 0635 (p >0.05). Conclusions: There is no spatial ability differencesbetween male and female athletes of KONI, West Java

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Sex differences in volume and structural covariance of the anterior and posterior hippocampus

Cited by 77 publications

References 75 publications

In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice

In vivo magnetic resonance images reveal neuroanatomical sex differences through the application of voxel-based morphometry in C57BL/6 mice

Sex Hormones and Cognition: Neuroendocrine Influences on Memory and Learning

Comparison of Spatial Ability Between Male and Female Athletes

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