Sex Differences of Risk Factors for Acute Myocardial Infarction in Japanese Patients

Kawano, Hiroaki; Soejima, Hirofumi; Kojima, Sunao; Kitagawa, Akira; Ogawa, Hisao

doi:10.1253/circj.70.513

Cited by 62 publications

(52 citation statements)

References 26 publications

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“…Given the almost universal participation of cases, any effect on risk estimates would be almost exclusively attributable to the compromise in the impaired representativeness of the control group. The relatively high participation proportion among controls and the fact that different characteristics of participants and nonparticipants, who were older and more frequently women, had little or no impact on the direction or magnitude of myocardial infarction risk estimates, as previous described (46) , reduced the probability of a non-response bias.…”

Section: Study Strengths and Limitationsmentioning

confidence: 59%

“…Moreover, most of them do not study properly differences by sex, which limits comparisons with our study. A recent case-control study stated that major risk factors for AMI in fact differ between men and women (46) and most authors agree that the different risk factor profiles may account for much of the sex differences in mortality (47) . However, in the present study a gender effect on AMI risk was found only for smoking and alcohol intake.…”

Section: Study Strengths and Limitationsmentioning

confidence: 99%

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Gender heterogeneity in the association between lifestyles and non-fatal acute myocardial infarction

Oliveira

Barros²,

Lopes³

2009

Public Health Nutr.

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Objective: To evaluate the modification effect of sex in the association between lifestyles and acute myocardial infarction (AMI). Design: Population-based case-control study. Trained interviewers collected information using a standard structured questionnaire. Associations were estimated using unconditional logistic regression. The effect modification by sex was evaluated in the regression models, testing interaction terms between lifestyles and sex. Setting: Porto, Portugal. Subjects: Portuguese Caucasian adults, aged $18 years. Cases were patients consecutively admitted with an incident AMI during 1999-2003 (n 918) and controls were a representative sample of non-institutionalized inhabitants of Porto with no evidence of previous clinical or silent infarction (n 2316). Results: Cigarette smoking was positively associated with AMI in both men and women (smokers .15 cigarettes/d v. never smokers: OR 5 9?11, 95 % CI 4?83, 17?20 for women; OR 5 3?92, 95 % CI 2?75, 5?58 for men; interaction term P value 5 0?001). A significant protective effect of moderate alcohol intake on AMI occurrence was found in women (0?1-15?0 g/d v. non-drinkers: OR 5 0?48, 95 % CI 0?31, 0?74), but not in men. Fruit and vegetable intake, vitamin and mineral supplement use and leisure-time physical activity practice were found to decrease AMI risk, with similar effects between sexes. Conclusions: A strong positive association between smoking and AMI was found in women. Also, a protective effect of moderate alcohol intake was only found among females. Fruit and vegetable intake, vitamin and mineral supplement use and leisure-time physical activity practice were found to decrease AMI risk in both sexes.

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Section: Study Strengths and Limitationsmentioning

confidence: 59%

Section: Study Strengths and Limitationsmentioning

confidence: 99%

Gender heterogeneity in the association between lifestyles and non-fatal acute myocardial infarction

Oliveira

Barros²,

Lopes³

2009

Public Health Nutr.

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“…Histological basis was given by Maes et al, who found a linear relation between percent fibrosis and MIBI uptake [10]. Considering that Japanese patients have different backgrounds for risk factors and lower cardiac hard event rate, we designed this multi-center cohort study with a larger number of patients [25,26]. Our study showed that sensitivity and specificity of functional recovery by non-gated %uptake were 68% and 64%, and those of ES %uptake were 80% and 52%, showing higher sensitivity of %ES uptake.…”

Section: Precedent Studies On Viability Assessmentmentioning

confidence: 99%

Prediction of functional recovery after revascularization using quantitative gated myocardial perfusion SPECT: a multi-center cohort study in Japan

Nakajima

Tamaki

Kuwabara

et al. 2008

Eur J Nucl Med Mol Imaging

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Backgrounds Prediction of left ventricular functional recovery is important after myocardial infarction. The impact of quantitative perfusion and motion analyses with gated single-photon emission computed tomography (SPECT) on predictive ability has not been clearly defined in multi-center studies. Methods A total of 252 patients with recent myocardial infarction (n=74) and old myocardial infarction (n=175) were registered from 25 institutions. All patients underwent resting gated SPECT using 99m Tc-MIBI, and repeated the study after revascularization after an average follow-up period of 132±81 days. Visual and quantitative assessment of perfusion and wall motion were performed in 5040 segments. Results Non-gated segmental %uptake and end-systolic (ES) %uptake were good predictors of wall motion recovery and significantly differed between improved and non-improved groups (66±17% and 55±18%, p<0.0001 for non-gated, 64±16% and 51±17% for ES %uptake, p<0.0001). The area under the curve (AUC) of receiver-operating characteristics curve (ROC) for non-gated %uptake, ES %uptake, end-diastolic (ED) %uptake and visual perfusion defect score was 0.70, 0.71, 0.61 and 0.56, respectively. Sensitivity and specificity of %uptake were 68% and 64% for non-gated map and 80% and 52% for ES %uptake map. An optimal threshold for predicting segmental improvement was 63% for non-gated and 52% for ES %uptake values. Conclusion Segmental 99m Tc-MIBI uptake provided a useful predictor of wall motion improvement. Application of quantitative approach with non-gated and ES %uptake enhanced predictive accuracy over visual analysis particularly in a multi-center study.

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“…There have been conflicting data regarding the relationship between obesity and coronary heart disease (CHD) in Japanese (1)(2)(3)(4)(5)(6)(7). Some prospective studies have revealed that obesity is a CHD risk factor after adjusting for other risk factors in Japan as well as in Western countries (1,2), but other case-control studies have not found the same result (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Some prospective studies have revealed that obesity is a CHD risk factor after adjusting for other risk factors in Japan as well as in Western countries (1,2), but other case-control studies have not found the same result (3)(4)(5). Washio …”

Section: Introductionmentioning

confidence: 99%

Age- and Gender-related Differences in Correlations between Abdominal Obesity and Obesity-related Metabolic Risk Factors in Japanese

Oda

Kawai

2009

Intern. Med.

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Sex Differences of Risk Factors for Acute Myocardial Infarction in Japanese Patients

Cited by 62 publications

References 26 publications

Gender heterogeneity in the association between lifestyles and non-fatal acute myocardial infarction

Gender heterogeneity in the association between lifestyles and non-fatal acute myocardial infarction

Prediction of functional recovery after revascularization using quantitative gated myocardial perfusion SPECT: a multi-center cohort study in Japan

Age- and Gender-related Differences in Correlations between Abdominal Obesity and Obesity-related Metabolic Risk Factors in Japanese

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