Sex disaggregated diabetes prevalence study in Guyana needed

Ostrow, Brian; Sibbald, R. Gary; Taha, Nashwah Y.; Lowe, Julia

doi:10.1016/j.diabres.2014.07.012

Cited by 3 publications

(5 citation statements)

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“…From July 2010 to March 2013, 7567 PWD were assessed with F/M = 2.09 [ 19 ]. As of March 2010, there were a cumulative 6075 patient visits to the GPHC foot center, an average of 13.6/day.…”

Section: Resultsmentioning

confidence: 99%

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The Guyana Diabetes and Foot Care Project: Improved Diabetic Foot Evaluation Reduces Amputation Rates by Two-Thirds in a Lower Middle Income Country

Lowe

Sibbald

Taha

et al. 2015

International Journal of Endocrinology

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Background. Type 2 diabetes is the fourth leading cause of death in Guyana, South America. A complex, interprofessional, quality improvement intervention to improve foot and diabetes care was rolled out in two phases. Methods & Findings. Phase 1: Establishment of an Interprofessional Diabetic Foot Center (DFC) of Excellence to improve foot care and reduce diabetes-related amputations at the national referral hospital. Phase 2: Regionalization to cover 90% of the Guyanese population and expansion to include improved management of diabetes and hypertension. Fourteen key opinion leaders were educated and 340 health care professionals from 97 facilities trained. Eight centers for the evaluation and treatment of foot ulcers were established and 7567 people with diabetes evaluated. 3452 participants had foot screening and 48% were deemed high risk; 10% of these had undocumented foot ulcers. There was a 68% reduction in rate of major amputations (P < 0.0001); below knee amputations were decreased by 80%, while above knee amputations were unchanged. An increased association of diabetes with women (F/M = 2.09) and increased risk of major amputation in men [odds ratio 2.16 (95% CI 1.83, 2.56)] were documented. Conclusions. This intervention improved foot care with reduction in major amputations sustained over 5 years.

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“…From July 2010 to March 2013, 7567 PWD were assessed with F/M = 2.09 [ 19 ]. As of March 2010, there were a cumulative 6075 patient visits to the GPHC foot center, an average of 13.6/day.…”

Section: Resultsmentioning

confidence: 99%

“…We have already reported on the divergence from global averages of the sex ratios of type 2 diabetes in Guyana and have estimated that the odds ratio for women compared to men is 2.486 (95% CI 2.442, 2.531, P < 0.0001) [ 19 ]. The sex-based risks for diabetes-related amputations in Guyana are reversed.…”

Section: Resultsmentioning

confidence: 99%

The Guyana Diabetes and Foot Care Project: Improved Diabetic Foot Evaluation Reduces Amputation Rates by Two-Thirds in a Lower Middle Income Country

Lowe

Sibbald

Taha

et al. 2015

International Journal of Endocrinology

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“…As we and others have reported, the over-representation of women with diabetes in Caribbean nations such as Guyana is a poorly understood phenomenon that appears isolated to the Caribbean and southern Africa. 4 5 21 In adulthood, male sex is a biological risk factor associated with a higher type 2 diabetes risk than female sex, due in part to increased insulin resistance, at any given body mass index. 19 22 This biological relationship may be offset by a relatively higher prevalence of obesity among Caribbean women versus men 5 21 —a gender difference rooted in the sociocultural perception of obese women as being healthier.…”

Section: Discussionmentioning

confidence: 99%

“…However, this approach may be misleading and could underestimate prevalence by 20% or more. 3 Moreover, the prevalence of diabetes is typically higher among men than women, 4…”

Section: Introductionmentioning

confidence: 99%

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Interaction between sex and rurality on the prevalence of diabetes in Guyana: a nationally representative study

Persaud

Singh

et al. 2020

BMJ Open Diab Res Care

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IntroductionDiabetes prevalence has never been measured in Guyana. We conducted a nationally representative cross-sectional study to estimate the prevalence of diabetes and pre-diabetes, and the association between sex and diabetes.Research design and methodsIn 2016, the Ministry of Public Health led Guyana’s first national STEPS survey among adults aged 18–69 years. Half of the participants were randomly selected for hemoglobin A1c and fasting blood glucose testing. We estimated the prevalence of diabetes and pre-diabetes and measured the association between sex and diabetes prevalence using logistic regression to compute adjusted ORs.ResultsWe included 805 adults (511 women, 294 men, mean age 41.8 (SD 14.4) years). The national prevalence of diabetes was 18.1% (95% CI: 15.4% to 20.8%), with higher rates among women (21.4%, 95% CI: 18.0% to 24.7%) than men (15.1%, 95% CI: 10.9% to 19.3%). Sex-specific diabetes prevalence varied significantly across urban and rural areas (p=0.002 for interaction). In rural areas, diabetes was twice as common among women (24.1%, 95% CI: 20.1% to 28.2%) compared with men (11.8%, 95% CI: 7.7% to 15.9%). After adjusting for prespecified covariates, rural women had double the odds of diabetes compared with rural men (OR 2.1, 95% CI: 1.20 to 3.82). This prevalence pattern was reversed in urban areas (diabetes prevalence, women: 13.9%, 95% CI: 8.7% to 19.0%; men: 22.0%, 95% CI: 12.9% to 31.1%), with urban women having half the odds of diabetes compared with urban men (OR 0.4, 95% CI: 0.20 to 0.99). We estimated that nearly one-third of women and over a quarter of men had diabetes or pre-diabetes.ConclusionsThe burden of diabetes in Guyana is considerably higher than previously estimated, with an unexpectedly high prevalence among women—particularly in rural areas.

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Development of an amperometric biosensor that can determine the amount of glucose in the blood using the glucose oxidase enzyme: Preparation of polyaniline–polypyrrole–poly(sodium‐4‐styrenesulfonate) film

Uzumer,

Cete,

Tekeli

et al. 2024

Biotech and App Biochem

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In this study, a new amperometric biosensor was developed for glucose determination. For this purpose, polyaniline–polypyrrole–poly(sodium‐4‐styrenesulfonate) film was prepared by electropolymerization of aniline and pyrrole with poly(sodium‐4‐styrenesulfonate) on a platinum plate. The best working conditions of the polyaniline–polypyrrole–poly(sodium‐4‐styrenesulfonate) film were determined. The glucose oxidase enzyme was immobilized by the entrapment method in polyaniline–polypyrrole–poly(sodium‐4‐styrenesulfonate) film. Glucose determination was made based on the oxidation of hydrogen peroxide, which is formed as a result of the enzymatic reaction on the surface of the prepared biosensor at +0.40 V. The working range for the glucose determination of the biosensor was determined. The effects of pH and temperature on the response of the glucose biosensor were investigated. The reusability and shelf life of the biosensor were determined. The effects of interference in biological environments on the response of the biosensor were investigated. Glucose determination was made in the biological fluid (blood) with the prepared biosensor. This study has a feature that sheds light on biosensor studies to be developed for the detection of substances in the human body, such as glucose, uric acid, and urea. This article will set an example for future scientific research on the development of a sensor for other biological fluids in the human body, such as the sensor developed for blood samples. In addition, this developed sensor provides an innovation that improves the quality of life of patients by allowing them to constantly monitor their glucose levels and intervene when necessary.

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Sex disaggregated diabetes prevalence study in Guyana needed

Cited by 3 publications

References 1 publication

The Guyana Diabetes and Foot Care Project: Improved Diabetic Foot Evaluation Reduces Amputation Rates by Two-Thirds in a Lower Middle Income Country

The Guyana Diabetes and Foot Care Project: Improved Diabetic Foot Evaluation Reduces Amputation Rates by Two-Thirds in a Lower Middle Income Country

Interaction between sex and rurality on the prevalence of diabetes in Guyana: a nationally representative study

Development of an amperometric biosensor that can determine the amount of glucose in the blood using the glucose oxidase enzyme: Preparation of polyaniline–polypyrrole–poly(sodium‐4‐styrenesulfonate) film

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