Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles

Gobrogge, Kyle L.

doi:10.1007/7854_2013_264

Cited by 13 publications

(12 citation statements)

References 248 publications

(331 reference statements)

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“…Sexually naïve, single male voles are highly social and display affiliative behavior toward novel conspecifics [ 7 ]. They can discriminate between males but not females, probably because identifying other males is more meaningful at this stage [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

“…These social behaviors favor stable family structures [ 3 – 6 ]. Once a pair bond is formed, it keeps prairie voles together for a long time, and when one of the voles dies, the survivor usually does not pair bond with a new mating partner [ 7 , 8 ]. Because of these characteristics, the prairie vole is ideal to study the neurobiological mechanisms involved in pair bonding [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

et al. 2020

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Microtus ochrogaster is a rodent with a monogamous reproductive strategy characterized by strong pair bond formation after 6 h of mating. Here, we determine whether mating-induced pair bonding increases cell proliferation in the subventricular zone (SVZ), rostral migratory stream (RMS), and dentate gyrus (DG) of the hippocampus in male voles. Males were assigned to one of the four groups: (1) control: males were placed alone in a clean cage; (2) social exposure to a female (SE m/f): males that could see, hear, and smell a sexually receptive female but where physical contact was not possible, because the animals were separated by an acrylic screen with small holes; (3) social exposure to a male (SE m/m): same as group 2 but males were exposed to another male without physical contact; and (4) social cohabitation with mating (SCM): males that mated freely with a receptive female for 6 h. This procedure leads to pair bond formation. Groups 2 and 3 were controls for social interaction. Male prairie voles were injected with 5-bromo-2′-deoxyuridine (BrdU) during the behavioral tests and were sacrificed 48 h later. Brains were processed to identify the new cells (BrdU-positive) and neuron precursor cells (neuroblasts). Our principal findings are that in the dorsal region of the SVZ, SCM and SE m/f and m/m increase the percentage of neuron precursor cells. In the anterior region of the RMS, SE m/f decreases the percentage of neuron precursor cells, and in the medial region SE m/f and m/m decrease the number of new cells and neuron precursor cells. In the infrapyramidal blade of the subgranular zone of the DG, SE m/m and SCM increase the number of new neuron precursor cells and SE m/m increases the percentage of these neurons. Our data suggests that social interaction, as well as sexual stimulation, leads to pair bonding in male voles modulating cell proliferation and differentiation to neuronal precursor cells at the SVZ, RMS, and DG.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

et al. 2020

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“…Different animal models have had different levels of success in research to develop treatments for both medical and psychiatric disorders (Gobrogge, 2014; Golbidi, Frisbee, & Laher, 2015; Griffin, 2002; McCairn & Isoda, 2013; McGonigle & Ruggeri, 2014; McKinney, 2001; McLarnon, 2014; Reser, 2014; Nestler & Hyman, 2010; Whiteside, Pomonis, & Kennedy, 2013). An animal model allows an experimenter to control the subject’s genetic background, environmental factors and prior drug experience.…”

Section: Criteria For An Animal Model Of Alcoholismmentioning

confidence: 99%

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

Bell

Hauser

Rodd

et al. 2016

International Review of Neurobiology

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The purpose of this review is to present up-to-date pharmacological, genetic and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid animal model of alcoholism with a highlight on its use as an animal model of polysubstance abuse, including alcohol, nicotine and psychostimulants. Pharmacologically and genetically, the focus will be on the neurotransmitter and neuropeptide systems that have received the most attention: cholinergic, dopaminergic, GABAergic, glutamatergic, serotonergic, noradrenergic, corticotrophin releasing hormone, opioid, and neuropeptide Y. Herein we sought to place the P rat’s behavioral and neurochemical phenotypes, and to some extent its genotype, in the context of the clinical literature. After reviewing the findings thus far, this paper discusses future directions for expanding the use of this genetic animal model of alcoholism to identify molecular targets for treating drug addiction in general.

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“…The prairie vole ( Microtus ochrogaster ) has recently emerged as a viable animal model for investigating the neurobiology of escalated aggression and violence [16], using advanced genetic tools to reveal the neural mechanisms mediating maladaptive and excessive agonistic behavior [17]. Ethologically, mating induces intense fatal forms of offensive attack behavior directed toward both male and female conspecifics but not toward their familiar female partner (i.e., selective aggression) in the wild; this can be modeled under well-controlled laboratory conditions [5;18].…”

Section: Animal Models Of Maladaptive Pathological Aggressionmentioning

confidence: 99%

Escalated aggression in animal models: shedding new light on mesocorticolimbic circuits

Miczek

Takahashi

Gobrogge

et al. 2015

Current Opinion in Behavioral Sciences

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Recent developments promise to significantly advance the understudied behavioral and neurobiology of aggression: (1) Animal models that capture essential features of human violence and callousness have been developed. These models range from mice that have been selectively bred for short attack latencies, monogamous prairie voles, and glucocorticoid-compromised rats to rodents and non-human primates that escalate their aggression after consuming or when withdrawing from alcohol. (2) Optogenetic stimulation and viral vector-based approaches have begun to identify overlapping and distinctive neural microcircuits and intracellular molecules for adaptive vs. excessive, maladaptive aggressive behavior in several rodent models. Projections from hypothalamic and mesencephalic neurons to the medial prefrontal cortex contain microcircuits that appear pivotal for the escalation of aggression.

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Sex, Drugs, and Violence: Neuromodulation of Attachment and Conflict in Voles

Cited by 13 publications

References 248 publications

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

Effects of Mating and Social Exposure on Cell Proliferation in the Adult Male Prairie Vole (Microtus ochrogaster)

A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction

Escalated aggression in animal models: shedding new light on mesocorticolimbic circuits

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