Sex–Gender Differences in Adult Coeliac Disease at Diagnosis and Gluten-Free-Diet Follow-Up

Galli, G.; Amici, Giulia; Conti, Laura; Lahner, Edith; Annibale, Bruno; Carabotti, Marilia

doi:10.3390/nu14153192

Cited by 12 publications

(3 citation statements)

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“…Another limitation could be the unbalanced sex ratio in the research sample. Previous research (Ivarsson et al, 2003;Bardella et al, 2005) has also shown that women are at greater risk of developing gluten sensitivity, and the symptoms are also more significant in women (Galli et al, 2022). Therefore, we can conclude that women consult a doctor sooner with their symptoms, while in the case of men, the disease remains hidden in many cases.…”

Section: Resultsmentioning

confidence: 61%

Factors Affecting the Consumer Behaviour of Gluten Sensitive Consumers – A Pilot Study

Zsigmond,

Feher,

Machova

et al. 2023

MMI

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The aim of this research was to assess the consumption habits of gluten sensitive individuals and to determine the factors affecting them. Owing to the development of medicine and new technologies, gluten sensitivity has been revealed in an increasing number ofcases. In addition, changes in modern lifestyles, as well as associated harmful consumption habits and changes in the health environment, have increased the incidence of gluten sensitivity. In terms of these facts, it has become extremely important to examine the consumer habits of this segment. With the help of this, it is possible to learn about the influence of the disease on consumers. The present research was completed on the basis of 862 questionnaires received in the autumn of 2022; the respondents (without exception) were individuals suffering from gluten sensitivity from Slovakia and Hungary. Factor analysis was performed to identify the main factors affecting consumption. Based on the results of the present research people affected by the disease do not make decisions based on one factor alone during their purchases. The study found that the factors influencing the consumption habits of gluten-sensitive individuals can be classified into four groups: “common”, “conscious”, “healthy lifestyle” and “price”. There are additional influencing elements within these groups. Based on the results, a revision and adjustment of tools influencing the consumption of gluten-free products should be performed. Factors affecting the consumer behaviour of gluten-sensitive consumers should be grouped (“Common”, ”Conscious”, ”Healthy lifestyle” and ”Price”). The analysis showed that the majority of gluten-sensitive individuals strictly adhere to the needed diet, but it is not important for them where they obtain the individual foods or the ingredients for their preparation. The present research contributes to the understanding of the lifestyle of gluten-sensitive consumers and can provide a suitable basis for further research.

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Section: Resultsmentioning

confidence: 61%

Factors Affecting the Consumer Behaviour of Gluten Sensitive Consumers – A Pilot Study

Zsigmond,

Feher,

Machova

et al. 2023

MMI

View full text Add to dashboard Cite

show abstract

“…This means that differences identified at the time of CD diagnosis were solved overtime according to the duodenal mucosal damage and independently from the anti-tTG IgA initial values. Approximately one-third of patients of both groups continued to present hypoferritinaemia, which may be due to a slow recovery of the iron deposits and/or unrelated to CD, as gynecologic disorders (polymenorrhea) in female patients have yet to be described in other studies [40].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical, Biochemical and Histological Features between Adult Celiac Patients with High and Low Anti-Transglutaminase IgA Titer at Diagnosis and Follow-Up

et al. 2023

Self Cite

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In adults, celiac disease (CD) diagnosis is based on specific serology (anti-transglutaminase IgA-anti-tTG) and duodenal histology. Evidence is raising the possibility of perform CD diagnosis based only on high anti-tTG titer in children. We aimed to evaluate clinical, histological and biochemical differences between adult patients with high tTG IgA titer (HT) and those with low titer (LT) at CD diagnosis and follow-up. This retrospective study included consecutive adult CD patients divided into two groups: HT (anti-tTG > 10 × ULN) and LT (anti-tTG < 10 × ULN). Clinical, biochemical and histological features were compared between groups at CD diagnosis and at follow-up. A total of 291 patients were included (HT: 47.1%; LT: 52.9%). At CD diagnosis, HT patients showed a non ‘classical’ presentation (p = 0.04), Marsh 3C (p = 0.005), hypoferritinaemia (p = 0.006) and osteopenia/osteoporosis (p = 0.04) more frequently than LT patients. A total of 216 patients (HT: 48.6%; LT: 51.4%) performed a follow-up after a median Gluten-free diet of 14 months; HT patients had persistent antibodies positivity (p = 0.001) more frequently and GI symptoms (p = 0.04) less frequently than LT patients. In conclusion, HT patients presented severe histological damage more frequently at diagnosis, recovering similarly to LT patients after the start of the Gluten-free diet. At follow-up, anti-tTG persisted positive in HT more frequently compared to LT patients, without differences regarding histological recovery and clinical improvement.

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“…Additionally, discrepancies in gut microbiota composition were influenced by factors such as obesityrelated metabolic diseases and the sequencing techniques employed for gut microbiota analysis. Consequently, certain contemporary studies even present contradictory trends when compared to the aforementioned results (Kim et al, 2021;Galli et al, 2022;Girdhar et al, 2023).…”

Section: Introductionmentioning

confidence: 98%

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

Huang,

Lyu,

Xie

et al. 2024

Front. Microbiol.

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Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized for its global prevalence and potential progression to more severe liver diseases such as non-alcoholic steatohepatitis (NASH). The gut microbiota plays a pivotal role in the pathogenesis of NAFLD, yet the detailed characteristics and ecological alterations of gut microbial communities during the progression from non-alcoholic fatty liver (NAFL) to NASH remain poorly understood. Methods: In this study, we conducted a comparative analysis of gut microbiota composition in individuals with NAFL and NASH to elucidate differences and characteristics. We utilized 16S rRNA sequencing to compare the intestinal gut microbiota among a healthy control group (65 cases), NAFL group (64 cases), and NASH group (53 cases). Random forest machine learning and database validation methods were employed to analyze the data. Results: Our findings indicate a significant decrease in the diversity of intestinal flora during the progression of NAFLD (p < 0.05). At the phylum level, high abundances of Bacteroidetes and Fusobacteria were observed in both NAFL and NASH patients, whereas Firmicutes were less abundant. At the genus level, a significant decrease in Prevotella expression was seen in the NAFL group (AUC 0.738), whereas an increase in the combination of Megamonas and Fusobacterium was noted in the NASH group (AUC 0.769). Furthermore, KEGG pathway analysis highlighted significant disturbances in various types of glucose metabolism pathways in the NASH group compared to the NAFL group, as well as notably compromised flavonoid and flavonol biosynthesis functions. The study uncovers distinct microbiota characteristics and microecological changes within the gut during the transition from NAFL to NASH, providing insights that could facilitate the discovery of novel biomarkers and therapeutic targets for NAFLD.

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Sex–Gender Differences in Adult Coeliac Disease at Diagnosis and Gluten-Free-Diet Follow-Up

Cited by 12 publications

References 50 publications

Factors Affecting the Consumer Behaviour of Gluten Sensitive Consumers – A Pilot Study

Factors Affecting the Consumer Behaviour of Gluten Sensitive Consumers – A Pilot Study

Comparison of Clinical, Biochemical and Histological Features between Adult Celiac Patients with High and Low Anti-Transglutaminase IgA Titer at Diagnosis and Follow-Up

From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patients

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