Sex hormone binding globulin for prediction of gestational diabetes mellitus in pre-conception and pregnancy: A systematic review

Faal, Shahla; Abedi, Parvin; Jahanfar, Shayesteh; Ndeke, Jonas M; Mohaghegh, Zaynab; Sharifipour, Foruzan; Zahedian, Maryam

doi:10.1016/j.diabres.2019.04.028

Cited by 31 publications

(25 citation statements)

References 47 publications

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“…A recent meta-analysis demonstrated that patients with GDM have substantially decreased SHBG levels compared with those without GDM [14]. SHBG is a glycoprotein mainly produced in the liver, and SHBG is thought to control the biological availability of sex hormones [26].…”

Section: Discussionmentioning

confidence: 99%

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Predictive Value of Circulating Sex Hormone-Binding Globulin for Gestational Diabetes: A Meta-Analysis

et al. 2021

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Aim: To detect predictive value of preconception or early pregnancy sex hormone-binding globulin (SHBG) for subsequent gestational diabetes mellitus (GDM). Materials & methods: We searched Embase, Medline, PubMed, Web of Science and Cochrane library up to January 2020. Studies assessing diagnostic performance of SHBG for GDM diagnosed by well-defined diagnostic criteria using oral glucose tolerance test. Results: Totally seven studies with 1947 women were included and 247 were diagnosed as GDM. SHBG had a combined diagnostic odds ratio of 6.68 (95% CI: 4.58–9.74), sensitivity of 0.70 (95% CI: 0.51–0.84), specificity of 0.74 (95% CI: 0.52–0.88), positive likelihood ratio of 2.49 (95% CI: 1.73–3.57) and negative likelihood ratio of 0.37 (95% CI: 0.23–0.61). The area under the summary receiver operating characteristic curve was 0.78 (95% CI: 0.74–0.82). Conclusion: SHBG had a predictive value for GDM and might improve GDM screening. However, heterogeneity between studies warrants more research into this topic.

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Section: Discussionmentioning

confidence: 99%

“…Although not fully understood, scientific evidence regarding the relationship of SHBG with GDM is also increasing. A systematic review showed that the level of SHBG is significantly lower in GDM pregnant women than that in healthy women, which suggested that SHBG might be a valuable biomarker for GDM [14].…”

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confidence: 99%

Predictive Value of Circulating Sex Hormone-Binding Globulin for Gestational Diabetes: A Meta-Analysis

et al. 2021

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“…104 Two recent systematic reviews elucidated the potential role of other first-trimester biochemical predictors such as inflammatory markers (C-reactive protein, tumor necrosis factor-alpha), insulin resistance markers (fasting insulin, sex hormone-binding globulin), adipocyte-derived markers (adiponectin, leptin) and placenta-derived markers (follistatin-like-3, placental growth factor, placental exosomes). 105,106 However, to convert the findings from observational studies of these biomarkers to clinical practice, strategies that use first-trimester biomarkers to avoid additional screening for GDM should be examined for effects on outcomes and costs.…”

Section: Additional Screening Methodsmentioning

confidence: 99%

An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review

Minschart¹,

Beunen²,

Benhalima³

2021

DMSO

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Gestational diabetes mellitus (GDM) is a frequent medical complication during pregnancy. Screening and diagnostic practices for GDM are inconsistent across the world. This narrative review includes data from 87 observational studies and randomized controlled trials (RCTs), and aims to give an overview of the current evidence on screening strategies and diagnostic criteria for GDM. Screening in early pregnancy remains controversial and studies show conflicting results on the benefit of screening and treatment of GDM in early pregnancy. Implementing the one-step "International Association of Diabetes and Pregnancy Study Groups" (IADPSG) screening strategy at 24-28 weeks often leads to a substantial increase in the prevalence of GDM, without conclusive evidence regarding the benefits on pregnancy outcomes compared to a two-step screening strategy with a glucose challenge test (GCT). In addition, RCTs are needed to investigate the impact of treatment of GDM diagnosed with IADPSG criteria on long-term maternal and childhood outcomes. Selective screening using a risk-factor-based approach could be helpful in simplifying the screening algorithm but carries the risk of missing significant proportions of GDM cases. A two-step screening method with a 50g GCT and subsequently a 75g oral glucose tolerance test (OGTT) with IADPSG could be an alternative to reduce the need for an OGTT. However, to have an acceptable sensitivity to screen for GDM with the IADPSG criteria, the threshold of the GCT should be lowered from 7.8 to 7.2 mmol/L. A pragmatic approach to screen for GDM can be implemented during the COVID-19 pandemic, using fasting plasma glucose (FPG), HbA1c or even random plasma glucose (RPG) to reduce the number of OGTTs needed. However, usual guidelines and care should be resumed as soon as the COVID pandemic is controlled.

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“…2018). Quando o DMG é diagnosticado ou previsto precocemente pode ser tratado através de intervenções apropriadas, como mudanças no estilo de vida ou meios farmacológicos para reduzir o impacto adverso na saúde (FAAL et al, 2019).…”

Section: Introductionunclassified

Abandono De Tratamento Da Tuberculose E Seus Padrões Espaciais. Pernambuco, 2008 a 2017

Silva¹,

Laurindo²,

Nascimento³

et al. 2021

Saúde Coletiva: Uma Abordagem Multidisciplinar

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Sex hormone binding globulin for prediction of gestational diabetes mellitus in pre-conception and pregnancy: A systematic review

Cited by 31 publications

References 47 publications

Predictive Value of Circulating Sex Hormone-Binding Globulin for Gestational Diabetes: A Meta-Analysis

Predictive Value of Circulating Sex Hormone-Binding Globulin for Gestational Diabetes: A Meta-Analysis

An Update on Screening Strategies for Gestational Diabetes Mellitus: A Narrative Review

Abandono De Tratamento Da Tuberculose E Seus Padrões Espaciais. Pernambuco, 2008 a 2017

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