Sex hormone binding globulin gene polymorphisms and metabolic syndrome in postmenopausal Turkish women

Sünbül, Murat; Eren, Fatih; Nacar, Cevdet; Ağırbaşlı, Mehmet

doi:10.5603/cj.2013.0074

Cited by 8 publications

(11 citation statements)

References 23 publications

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“…Four of the tested SNPs (rs6259, rs6257, rs1799941 and rs727428) were previously studied in relation to their association with PCOS, but with variable results [19,20,27] . The remaining 3 SNPs (rs989887, rs13894, rs858521) were also investigated, but in relation to their effects on SHBG levels and cancer and osteoporosis [21,22,25,26,28] . Our study demonstrated a significant link between rs727428, but not the other studied SNPs, and PCOS and hyperandrogenism in Bahraini women.…”

Section: Discussionmentioning

confidence: 99%

“…Studies documented association between SHBG polymorphisms with altered glucose homeostasis, some of which linked it with altered SHBG levels, while others suggested that it was independent of changes in SHBG levels [16,[19][20][21][22] . In view of the link between PCOS and altered glucose homeostasis and IR [4,23] , it was suggested that altered SHBG secretion, stemming from specific SHBG polymorphisms, might contribute to PCOS pathogenesis.…”

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confidence: 99%

“…For example, studies on predominantly Caucasian populations demonstrated differential association of rs6257, rs6259 (D356N), rs727428 and rs1799941 SHBG variants with decreased SHBG levels and PCOS presence [16,19,20,24] . Other SHBG variants, including rs13894, rs858521 and rs9898876, were also investigated as to their association with altered SHBG levels, but in T2DM and IR [21,22,25,26] . Such a study has yet to be carried out in Middle Eastern women.…”

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confidence: 99%

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Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

Abu-Hijleh

Gammoh²,

Al-Busaidi³

et al. 2015

Ann Nutr Metab

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Background: Decreased sex hormone-binding globulin (SHBG) levels were associated with polycystic ovary syndrome (PCOS). SHBG polymorphisms associated with reduced SHBG production were tested for their association with PCOS, but with inconclusive results. We tested whether altered SHBG levels and SHBG variants were associated with PCOS. Methods: The study subjects included 242 women with PCOS and 238 control women. SHBG genotyping was done by real-time PCR. Results: Higher minor allele frequency of rs13894, rs858521 and rs727428 was seen in PCOS cases, and significant differences in rs858521 and rs727428 genotypes distribution were seen between PCOS cases and controls. Multivariate regression analysis confirmed the association of only rs727428 with PCOS. Though it was not statistically significant, serum SHBG levels were reduced according to rs727428 genotypes in PCOS cases than in controls. Carriage of rs727428 minor allele was associated with significant increases in free/bioactive testosterone in PCOS cases. Seven-locus (rs9898876-rs13894-rs858521-rs1799941-rs6257-rs6259-rs727428) haploview analysis showed increased frequency of GCCGTGA, GTCGTGA and GTCATGG, and reduced frequency of GTCGTGG haplotypes in PCOS cases than in controls, thus conferring disease susceptibility and protective nature to these haplotypes, respectively. Conclusion: Specific SHBG variants affecting serum SHBG levels and SHBG haplotypes are associated with PCOS, suggesting the role for SHBG as PCOS candidate gene.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

Abu-Hijleh

Gammoh²,

Al-Busaidi³

et al. 2015

Ann Nutr Metab

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“…Therefore, genetic factors that lower SHBG levels may potentially affect MetS defining traits, including high blood pressure, and obesity [ 40 ]. SHBG polymorphisms associate with insulin resistance [ 41 , 42 ]. Previous studies report that the G allele of rs1799941 in SHBG associates with lower SHBG levels [ 40 – 42 ].…”

Section: Discussionmentioning

confidence: 99%

SHBG Gene Polymorphism (rs1799941) Associates with Metabolic Syndrome in Children and Adolescents

et al. 2015

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BackgroundMetabolic syndrome (MetS) is a complex disorder characterized by coexistence of several cardiometabolic (CM) factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD). The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.MethodsGenetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs), previously shown to modulate lipid or sex hormone binding globulin (SHBG) levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls).ResultsLogistic regression analysis revealed a significant association between rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006). The association with MetS remained after sequential adjustment for each CM factor included in the syndrome definition, indicating that the identified association is not being driven by any single trait. A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. In control subjects, the A allele of rs1799941 associated with a significant increase in SHBG levels (p = 0.012), while in cases there was no association between rs1799941 and SHBG levels (p = 0.963).ConclusionsThe significant association between rs1799941 and MetS in children is not contingent on any single CM trait. Additionally, the presence of MetS may abrogate effect of rs1799941 polymorphism on SHBG levels in children.

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“…It is very meritorious that the above mentioned authors have duly enlighte ned other aspects of the MetS, not necessarily related to the CV or endocrine systems [2]. For instance, MetS was found to be associated with increased blood lead levels [3], sex hormone bin ding globulin gene polymorphisms [4], augmented neck circumference [5] and heart rate turbulence [6]. Therefore, the authors' findings are in line with our opinion that MetS is a multifactorial and polyfacetic syndrome, standing basically on 2 tightly knotted conditions: obesity and insulin resistance.…”

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confidence: 99%

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Fisman

Tenenbaum

2014

Cardiol J

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Sex hormone binding globulin gene polymorphisms and metabolic syndrome in postmenopausal Turkish women

Abstract: (r = 0.203, p = 0.024 (Cardiol J 2013; 20, 3: 287-293)

Cited by 8 publications

References 23 publications

Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome

SHBG Gene Polymorphism (rs1799941) Associates with Metabolic Syndrome in Children and Adolescents

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