Sex hormone binding globulin in breast cancer

L, Dayalu Naik S; Hedau, Suresh; Bahadur, Anil Kumar; Saha, Renuka; Kaur, Simran; Ray, Arunima

doi:10.1007/s12291-008-0056-9

Cited by 5 publications

(1 citation statement)

References 24 publications

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“…The elevated concentration of globulin in female dogs with CMT is probably related to the increase in the concentration of hormone binding globulins. This type of globulin specifically binds to testosterone and estradiol, thereby functionally regulating the concentration of free steroidal hormones [44]. The main results include increased glucose and decreased globulins during omega-3 treatment and absence of altered lipid profile during the period of omega-3 supplementation.…”

Section: Discussionmentioning

confidence: 99%

Lipid and metabolic profiles in female dogs with mammary carcinoma receiving dietary fish oil supplementation

et al. 2019

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BackgroundDyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas and their correlations with body condition score and degree of tumor malignancy, as well as to study the effect of dietary fish oil supplementation on these animals.ResultsOverweight or obese dogs had more aggressive carcinomas and higher triglyceride (p = 0.0363), VLDL (p = 0.0181), albumin (p = 0.0188), globulin (p = 0.0145) and lactate (p = 0.0255) concentrations. There was no change in the lipid profile after supplementation with fish oil at any concentration. However, in relation to the metabolic profile, glucose (p = 0.0067), total protein (p = 0.0002) and globulin (p = 0.0002) concentrations were increased when 90% omega-3 fish oil was used as a dietary supplement.ConclusionObese dogs showed altered lipid and metabolic profiles and more aggressive tumors, suggesting an important relationship between dyslipidemia and tumor aggressiveness. Supplementation with fish oil, rich in omega-3 fatty acids, may alter metabolic parameters in cancer patients.

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Section: Discussionmentioning

confidence: 99%