Sex hormone regulation of collagen concentrations in cranial cruciate ligaments of sexually immature male rabbits

Abstract

Sex hormones appeared to play a role in cranial cruciate ligament homeostasis in male rabbits. Physiologic changes triggered by the lack of sex hormones following gonadectomy in sexually immature rabbits may potentially predispose those rabbits to orthopedic injuries.

Neo-natal castration leads to subtle differences in porcine anterior cruciate ligament morphology and function in adolescence

“…When looking at the bundle function across skeletal growth and overall joint size, the timing seems to support an earlier maturation in boars than in barrows, yet CSA and stiffness values seems to indicate no difference in ACL maturation. Perhaps testosterone has greater influence on the microstructural properties of the collagen fibers in the ACL, as shown by a decrease in collagen content and increase in collagen fiber diameter in castrated male rabbits [44]. Given that the rise of testosterone in boars starts around 4-months [45], the slight difference in timing of functional changes could be influenced more by testosterone especially between the 3-month and 4.5-month range.…”

Influência dos hormônios sexuais femininos no remodelamento e na reatividade das vias aéreas em modelo murino de inflamação pulmonar alérgica crônica.

“…A fibrose subepitelial participa da indução do enrijecimento permanente das pequenas vias aéreas na asma e pode afetar sua contração e seu relaxamento (PINELLI et al, 2009). Tais alterações funcionais podem interferir na morbidade da doença e diminuir a resposta terapêutica à medicações (ACEVES et al, 2008 (LIGHT et al, 2012). Assim, a ausência de estrógenos (potenciais inibidores da deposição de colágeno) e a presença de progesterona (indutora da deposição de colágeno) favoreceria o aumento da deposição deste elemento no grupo OVx alérgico+P.…”