Sex Hormone Suppression by Intrathecal Opioids: A Prospective Study

Roberts, Lindy J.; Finch, Philip M.; Pullan, P. T.; Bhagat, C.I.; Price, Leanne

doi:10.1097/00002508-200205000-00002

Cited by 114 publications

(90 citation statements)

References 32 publications

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“…50 Chronic heroin abuse depresses testicular function through the inhibition of release of LH from the pituitary and the hormonal changes returned promptly to normal after withdrawal. 51 Whether erectile function could be restored needs further study. Hypersexuality episodes may be observed in men experiencing opiate withdrawal, with spontaneous erections and nocturnal ejaculation.…”

Section: ) Opioidsmentioning

confidence: 99%

Erectile Dysfunction Associated with Psychoactive Substances

Jiann

2008

Chonnam Med J

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Psychoactive substances are believed to be aphrodisiac; but in reality they have deleterious effects on all the aspects of sexual function. The purpose of this article is to review and summarize the available scientific literature on the impact of psychoactive substances, including alcohol, tobacco and illicit drugs on erectile dysfunction (ED) in men. Almost all of them have been reported to be associated with ED. These substances may exert their inhibitory effect on erection through their effects on central neurotransmitter pathways (serotogenic, adrenergic or dopaminergic). Besides, some also may exhibit vasoconstricting properties (cocaine), impair endothelium function (nicotine) or suppress the release of luteinizing hormone from the pituitary, resulting in hypogonadism (morphine) to induce ED. The relationship between ED and psychoactive substances is attributed not only to pharmacological effects, but also to psychological and social reactions to substance dependence. Whether withdrawal from the substances could restore erectile function remains unknown. However, human and animal studies demonstrated that the effects of neurological damage from chronic substance abuse are long-lasting. This information of sexual consequence of the substances will be of great general interest and may serve as a powerful tool to healthcare providers.

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Section: ) Opioidsmentioning

confidence: 99%

Erectile Dysfunction Associated with Psychoactive Substances

Jiann

2008

Chonnam Med J

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“…It has been confirmed that heroin abusers have serious sexual dysfunction, including decreased sexual drive, erectile dysfunction and delayed ejaculation [52][53][54][55][56], and that heroin-induced sexual potency reduction is associated with directing blood flow away from the genitals. Further, it direcly correlates with the deteriorated physical and psychological status and living environment of heroin users [57].…”

Section: Outcomementioning

confidence: 99%

The effect of nucleus accumbens lesions on appetite, sexual function, and nicotine dependence in recovering heroin addicts

Wang

Zhu

Chen

et al. 2013

Translational Neuroscience

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The nucleus accumbens (NAc) is a key part of the neural circuitry that creates reward, pleasure and motivation that facilitates human feeding, sexual and smoking behaviors. In the brain reward system, the NAc is a crucial component responsible for natural and drug-induced reinforcement behaviors. Yet it is unclear whether NAc is indispensible for all reward behaviors in human beings. The present study aimed to investigate the long-term effects of NAc ablation on sexual function, appetite, and nicotine dependence level in chronic heroin users. Eighteen former heroin-dependent patients (male) with bilateral NAc ablation via stereotactic radiofrequency surgery for alleviating drug psychological dependence were recruited. Their postoperative time ranged from 12 to 103 months. All subjects received MRI scans for assessing the accuracy of the lesion site. Evaluation of appetite, sexual function, and nicotine dependence were measured using the Simplified Nutrition Appetite Questionnaire, the Brief Sexual Function Inventory, and the Fagerström Test for Nicotine Dependence, respectively. After precluding the potential confounding variables, such as drug use (dosage and duration), post-operation duration, age, body-weight, marital status and education level, ANOVA with repeated measures revealed that the NAc ablation improved the patients' appetite, sexual drive and sexual satisfaction. Yet there was no change in male erectile function, ejaculatory function, or nicotine dependence levels compared to the preoperative. These may suggest that although NAc is a key part of the neural circuitry, the NAc surgical lesions left the fundamental aspects of natural and drug-induced reinforcement and motivation almost intact.

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“…Fait très intéressant, l'administration d'opioïdes entraîne l'inhibition de l'axe hypothalamo-hypophysogonadique. Il en découle une diminution des niveaux de testostérone [44]. Il faut donc toujours garder à l'esprit de compenser cette baisse d'androgènes lors d'une administration chronique d'opioïdes afin de ne pas enclencher un cercle vicieux.…”

Section: Et Chez L'humain ?unclassified

Sex hormones and endogenous pain modulation mechanisms

Gaumond

2009

Douleur analg

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Sex Hormone Suppression by Intrathecal Opioids: A Prospective Study

Cited by 114 publications

References 32 publications

Erectile Dysfunction Associated with Psychoactive Substances

Erectile Dysfunction Associated with Psychoactive Substances

The effect of nucleus accumbens lesions on appetite, sexual function, and nicotine dependence in recovering heroin addicts

Sex hormones and endogenous pain modulation mechanisms

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