Sex hormone therapy and progression of cardiovascular disease in menopausal women

Alhurani, Rabe E.; Chahal, C. Anwar A.; Ahmed, Ahmed T.; Mohamed, Essa A.; Miller, Virginia M.

doi:10.1042/cs20160042

Cited by 15 publications

(9 citation statements)

References 54 publications

(62 reference statements)

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“…The postmenopausal prevalence rate was similar to that of males. This trend was similar with primary cardiovascular disease in women [11]. Therefore, we believe gender or hormones in female BD patients might protect from vascular involvement.…”

Section: Discussionsupporting

confidence: 74%

Demography of vascular Behcet’s disease with different gender and age: an investigation with 166 Chinese patients

Chen

Cai

et al. 2019

Orphanet J Rare Dis

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Background The Clinical features of vascular Behcet’s disease (BD) are not well understood because there are few studies. Our study aimed to investigate characteristics of vascular BD in both genders in different age groups. Results We enrolled 923 patients with BD who presented to our hospital with adequate medical histories and proper vascular screening exams. The raw incidence rate of vascular BD was 17.98% (166/923). The ratio of vascular BD in male to female patients was 1.868 ( p = 0.0004, 95% confidence interval (CI): 1.317 to 2.625). There was a tendency towards higher ESR and CRP in vascular BD patients than in mucocutaneous, but the difference was not significant. The most susceptible affected vessels were cerebral (29.6% in males, 59.4% in females) and lower limb vessels (31.2% in males, and 17.2% in females). The incidence of vascular involvement in younger (< 50 years old) and older (≥ 50 years old) patients were similar, with ratios of 16.58% (122/736) and 23.53% (44/187) respectively. However, in females, younger patients were less likely to have vascular involvement than were older patients (11.43% vs. 20% p = 0.0328, OR: 0.5161, 95% CI: 0.2874 to 0.912). Aneurysm or pseudoaneurysm was diagnosed in 1.84% (17/923) patients, mostly in male patients ( p < 0.05, OR: 3.221, 95% CI: 1.097 to 9.112). Twenty vascular BD patients were followed up, and the age at BD diagnosis was 33.23 ± 11.56 year. This did not differ statistically with their age at vascular involvement (36.15 ± 9.52 years). Ages of vascular BD patients did not differ significantly from those of mucocutaneous BD patients ( n = 143) in both males and females. Conclusion Vascular BD, including lethal types of aneurysm is more likely to occur in male patients. The female patients has a similar incidence rate with the males in their postmenopausal age. There was no evidence of progression course from mucocutaneous BD to vascular involvement.

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Section: Discussionsupporting

confidence: 74%

Demography of vascular Behcet’s disease with different gender and age: an investigation with 166 Chinese patients

Chen

Cai

et al. 2019

Orphanet J Rare Dis

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“…It is well established that estrogen has favorable effects on endothelial and cardiac function 5,37 and loss of estrogen at menopause is associated with an increased risk of cardiovascular disease. 38 In the present study, only minor differences in cardiac dimensions and systolic and diastolic function were detected between the premenopausal and recent postmenopausal women at baseline.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Adaptations to High‐Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study

Egelund

Jørgensen

Mandrup

et al. 2017

JAHA

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BackgroundWe examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause.Methods and ResultsTwo groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular disease and with a mean age difference between groups of only 4 years were studied. Cardiac dimensions and systolic and diastolic function were determined by transthoracic echocardiography with tissue Doppler imaging and 2‐dimensional speckle tracking. Measurements were performed at baseline and after a 12‐week period of high‐intensity aerobic cycle training. LV internal diastolic diameter and LV mass were similar in the 2 groups at baseline and increased by ≈2% to 8% (P=0.04–0.0007) with training in both groups. Left atrial end‐diastolic and end‐systolic volumes were similar for both groups and increased by 23% to 36% (P=0.0006–0.0001) with training. Systolic function assessed by mean global strain was similar in both groups at baseline and increased by ≈8% (P=0.0004) with training in the postmenopausal group. LV displacement increased by ≈3% (P=0.04) in the premenopausal women only. Diastolic function assessed by E/A ratio was similar at baseline and increased by ≈7% (P=0.01) in the premenopausal group and 11% (P=0.0001) in the postmenopausal group with training.ConclusionsThese results suggest that training‐induced cardiac adaptations are preserved in the early postmenopausal phase. Furthermore, the hormonal changes associated with the menopausal transition do not appear to affect cardiac dimensions and function.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02135575.

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“…■ decade, perhaps one of the most controversial medical decision facing women and their physicians is the use of sex hormones during menopause and the impact of their use on cardiovascular health. In her review, 'Sex hormone therapy and progression of cardiovascular disease in menopausal women' 25 , Virginia Miller summarises results of major observational, primary and secondary prevention studies, provides evidence for how sex steroids modulate cardiovascular function and identifies challenges for future research.…”

Section: Cardiologymentioning

confidence: 99%

Gender Medicine – the heart and mind of the latest findings in our collection from Clinical Science

Pettengale¹

2017

The Biochemist

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Gender Medicine focuses on the impact of gender on human physiology, pathophysiology, and clinical features of diseases. Men and women may have different experiences of the same disease and the pathophysiology of disease may also vary as a function of genetics, epidemiology and biological sex/gender. Translating molecular bioscience and experimental research into medical insights, the journal Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health. Together with leaders in the field of gender medicine, we have put together a special themed collection of the journal focusing on this often neglected dimension of medicine.

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Sex hormone therapy and progression of cardiovascular disease in menopausal women

Cited by 15 publications

References 54 publications

Demography of vascular Behcet’s disease with different gender and age: an investigation with 166 Chinese patients

Demography of vascular Behcet’s disease with different gender and age: an investigation with 166 Chinese patients

Cardiac Adaptations to High‐Intensity Aerobic Training in Premenopausal and Recent Postmenopausal Women: The Copenhagen Women Study

Gender Medicine – the heart and mind of the latest findings in our collection from Clinical Science

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