Sex Hormones as Modulators of Liver Tumor Development

Vesselinovitch, S. D.; Mihailovich, N.; Negri, S

doi:10.1007/978-1-4613-0957-4_5

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…The reasons for the weak enhancing effects of perinatal exposure on the carcinogenic activity of ETU are unknown. Although at least 38 chemicals have been shown to induce neoplasms in experimental animals following in utero exposure, the neonatal period (up to approximately 3 weeks of age in mice) has been shown to be the most susceptible period for the carcinogenicity of a variety of agents (Vesselinovitch et al, 1979). The transplacental effect of chemicals depends on many factors, including strain and sex of the species studied, precise time of in utero exposure, mutagenicity or genotoxicity of the chemical, and whether the chemical requires metabolic activation or is direct acting (Alexandrov, 1983;Rice et al, 1989).…”

Section: Effects Of Perinatal Exposurementioning

confidence: 99%

Protectiveness of NAM-based hazard assessment – which testing scope is required?

2023

ALTEX

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The study designs included conventional 2-year exposure of adult animals, perinatal exposure only, and perinatal plus adult exposure. The studies were intended to compare and evaluate the potential value of perinatal exposures in assessing chemical carcinogenicity. After much discussion, the consensus of the Subcommittee was that there was not an overwhelming effect of perinatal exposure to ETU on increased incidences of neoplasms. However, Dr. Gold suggested that the results should be reorganized and reported in terms of three questions addressed by the experimental design: (1) were there effects of perinatal exposure?, (2) were there carcinogenic effects in a typical 2-year bioassay?, and (3) did perinatal exposure enhance or potentiate carcinogenic effects seen in a subsequent 2-year bioassay? The Subcommittee recommended unanimously that the Technical Report be deferred for further consideration so that the questions raised could be addressed in a revision of the report.

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Section: Effects Of Perinatal Exposurementioning

confidence: 99%

Protectiveness of NAM-based hazard assessment – which testing scope is required?

2023

ALTEX

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Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice

Rodriguez¹

1997

Carcinogenesis

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The present study determined tumorigenicity, tumor classification and DNA damage induced in infant mice by benzo[a]pyrene (B[a]P) or Manufactured Gas Plant (MGP) residues after a single exposure. Male and female B6C3F1 mice were exposed to B[a]P or MGP residue from a single environmental site (MGP-4) and males were also exposed to MGP residue composite from seven different sites (MGP-M7). At 26, 39 and 52 weeks after exposure tumorigenesis was assessed in lung, forestomach and liver. Formation and persistence of DNA adducts were quantified by 32P-postlabeling. Exposure of males to B[a]P induced liver tumors in a dose and time dependent manner. MGP induced more advanced tumors than B[a]P. Only a single liver tumor was found in MGP-4 treated females. No forestomach and few pulmonary adenomas were induced in males or females. MGP-4, MGP-M7 or B[a]P induced DNA adducts in males and females. Adducts in liver, lung and forestomach peaked on different days and decreased at different rates. At 24 h post-exposure, no significant differences in initial DNA adduct levels occurred in males and females exposed to MGP-4 or B[a]P. Lack of DNA damage (adducted DNA) did not account for non-responsiveness of lung and forestomach in B6C3F1 genders as well as in liver in females. MGP tumorigenicity could not be accounted for solely by B[a]P content nor did it reflect additivity of B[a]P and other carcinogenic polycyclic aromatic hydrocarbons (PAHs) in MGP. Synergy among MGP-PAHs, presence of unidentified carcinogens and/or promoters in MGP may account for MGP potency. The B6C3F1 infant male model is a convenient and rapid assay for assessing MGP liver tumorigenicity and potency.

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Sex Hormones as Modulators of Liver Tumor Development

Cited by 2 publications

References 10 publications

Protectiveness of NAM-based hazard assessment – which testing scope is required?

Protectiveness of NAM-based hazard assessment – which testing scope is required?

Carcinogenicity of benzo[a]pyrene and manufactured gas plant residues in infant mice

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