Sex Hormones Predict the Incidence of Erectile Dysfunction: From a Population-Based Prospective Cohort Study (FAMHES)

Luo, Yue; Zhang, Haiying; Liao, Ming; Tang, Qin; Huang, Yuzhen; Xie, Jinling; Tang, Yan; Gao, Yong; Yao, Ziting; Jiang, Yonghua; Lin, Xinggu; Wu, Chunlei; Yang, Xiaobo; Mo, Zengnan

doi:10.1111/jsm.12854

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…In men, the majority of testosterone (approximately 55%) that binds to serum SHBG is not biologically active; therefore, serum TT levels do not accurately reflect the actual BT levels. Liang (2016) found that ED severity is associated with the serum BT levels and SHBG level rather than to TT levels in middle-aged and elderly men, in agreement with a prospective cohort study by Luo et al (2015), which showed that SHBG might be an independent predictor of ED, a finding that remained true after excluding age as a variable.…”

Section: Shbg and Edsupporting

confidence: 58%

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Research progress on the relationship between sex hormone‐binding globulin and male reproductive system diseases

et al. 2020

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Sex hormone-binding globulin, also known as testosterone-estradiol-binding globulin, is a multifunctional protein synthesised by hepatocytes. Sex hormone-binding globulin specifically binds and transports sex hormones to regulate plasma bioactive sex hormone levels and affects their bioavailability. As male sex hormone expression is dominated by testosterone, the binding of sex hormone-binding globulin with testosterone leads to the reduction in bioavailable testosterone, which cannot fulfil its physiological roles, thereby resulting in male infertility, erectile and gonadal dysfunction, prostate cancer and other male reproductive system diseases. Sex hormonebinding globulin may be involved in the pathogenesis of male reproductive system diseases, seriously affecting the quality of life of men. In this article, we review the association between sex hormone-binding globulin and male reproductive system diseases.

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Section: Shbg and Edsupporting

confidence: 58%

“…Furthermore, Luo et al (2015) found a significant positive correlation between SHBG and ED in a cross-sectional study of older men.…”

Section: Shbg and Edmentioning

confidence: 82%

Research progress on the relationship between sex hormone‐binding globulin and male reproductive system diseases

et al. 2020

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“…Besides vascular or neurogenic causes, hormonal factors seem to play a major role in the development and maintenance of ED ( Mola, 2015 ). Higher levels of testosterone (T) and dehydroepiandrosterone (DHEA) as well as estradiol (E2) have been reported to be associated with better overall sexual function and less ED in different age groups ( Finkelstein et al, 2013 ; Luo et al, 2015 ; Rabijewski, Papierska, Kuczerowski, & Piątkiewicz, 2015 ), although there is conflicting literature on the association between E2 and ED ( El-Sakka, 2013 ; O’Connor et al, 2011 ; Vignozzi et al, 2014 ). A recent study reported that changes in T and E2 levels in response to T treatment were associated with improvements in sexual activity and sexual desire, but not erectile function in older men ( Cunningham et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Psychobiological Protective Factors Modifying the Association Between Age and Sexual Health in Men: Findings From the Men’s Health 40+ Study

et al. 2017

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Sexual health severely decreases with age. For males older than 40 years, erectile dysfunction (ED) is the most common sexual disorder. Although physical and psychological risk factors for ED have been identified, protective factors are yet to be determined. To date, no study has examined endocrine and psychosocial factors in parallel with regard to their modifying effect on the age-related increase in ED. Two hundred and seventy-one self-reporting healthy men aged between 40 and 75 years provided both psychometric data on sexual function and a set of potential psychosocial protective factors, and saliva samples for the analysis of steroid hormones and proinflammatory cytokines. Around 35% of the participants reported at least a mild form of ED. Direct associations with ED were identified for perceived general health, emotional support, relationship quality, intimacy motivation but not for steroid hormones or proinflammatory markers. Moderation analyses for the association between age and ED revealed positive effects for testosterone (T), dehydroepiandrosterone (DHEA), perceived general health, emotional support, intimacy motivation, and a negative effect for interleukin-6 (all p < .05; f2 > .17). Group differences between older men with and without ED emerged for T, DHEA, and psychometric measures such as perceived general health, emotional support, satisfaction with life, and intimacy motivation (all p < .05; d > .3). Both psychosocial and endocrine parameters moderated the association between age and sexual health. Perceived general health, emotional support, intimacy motivation, and relationship quality emerged as psychosocial protective factors against ED. Higher T and DHEA and lower interleukin-6 levels also buffered against an age-related increase in ED.

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“…The BioT is increased in patients with HCV after the DAA therapy. This elevation enhances the androgenic action (Ring et al., 2017) and is related to sexual function (Huang et al., 2019; Kapoor, Clarke, Channer, & Jones, 2007; Luo et al., 2015).…”

Section: Discussionmentioning

confidence: 99%

Effect of new oral direct acting antiviral therapy on sexual function in male patients with hepatitis C virus

Akl

Salah

2020

Andrologia

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Hepatitis C virus (HCV) infection is a major health problem all over the world including Egypt. Chronic HCV infection is usually accompanied by decrease of libido and erectile dysfunction. This study aimed to evaluate the efficacy of new oral direct acting antiviral (DAA) therapy on sexual function of male patients with HCV. This study was conducted on 200 male participants divided into two groups, first group included 100 male patients with HCV and the second group included 100 healthy age matched males as a control. Patients received DAA for three months and virological free status was confirmed by polymerase chain reaction. All participants were subjected to full history taking, general examination and local genital examination, assessment of sexual function by a validated Arabic version of the international index of erectile function‐5. Laboratory investigations included liver functions serum testosterone, free testosterone, sex hormone‐binding globulin and bioavailable testosterone. Results of this study showed that patients with HCV suffer from sexual dysfunction than controls that significantly improved after DAA therapy, and this is accompanied by increasing of bioavailable testosterone. It could be concluded that beside its effectiveness in treatment of HCV infection, DAA therapy can improve sexual function in male patients with HCV.

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Sex Hormones Predict the Incidence of Erectile Dysfunction: From a Population-Based Prospective Cohort Study (FAMHES)

Cited by 14 publications

References 42 publications

Research progress on the relationship between sex hormone‐binding globulin and male reproductive system diseases

Research progress on the relationship between sex hormone‐binding globulin and male reproductive system diseases

Psychobiological Protective Factors Modifying the Association Between Age and Sexual Health in Men: Findings From the Men’s Health 40+ Study

Effect of new oral direct acting antiviral therapy on sexual function in male patients with hepatitis C virus

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