Sex identification of a Late Iron Age sword and mirror cist burial from Hillside Farm, Bryher, Isles of Scilly, England

Mays, S.; Parker, Glendon J.; Johns, Christopher; Stark, Sarah; Young, Andrew; Reich, David; Buikstra, Jane E.; Sawyer, Kristi; Hale, Kathy

doi:10.1016/j.jasrep.2023.104099

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Gasparini et al [334] performed enamel sex estimation of skeletal remains from two VII century CE necropolises and identified the sex of skeletons buried in non-gendered graves. Similarly, Mays et al [335] identified the sex of highly degraded skeletal remains dated 1 st century BCE overcoming the limitation posed by high-throughput DNA sequencing, that failed as no aDNA survived in such remains. Olszewski et al [336] recently conducted proteomic analyses on human remains from a Dutch East India Company burial ground in South Africa and managed confirm the biological sex of the remains from these poorly preserved samples.…”

Section: Proteomics For Personal Identificationmentioning

confidence: 99%

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From flesh to bones: Multi‐omics approaches in forensic science

Procopio,

Bonicelli

2024

Proteomics

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Recent advancements in omics techniques have revolutionised the study of biological systems, enabling the generation of high‐throughput biomolecular data. These innovations have found diverse applications, ranging from personalised medicine to forensic sciences. While the investigation of multiple aspects of cells, tissues or entire organisms through the integration of various omics approaches (such as genomics, epigenomics, metagenomics, transcriptomics, proteomics and metabolomics) has already been established in fields like biomedicine and cancer biology, its full potential in forensic sciences remains only partially explored. In this review, we have presented a comprehensive overview of state‐of‐the‐art analytical platforms employed in omics research, with specific emphasis on their application in the forensic field for the identification of the cadaver and the cause of death. Moreover, we have conducted a critical analysis of the computational integration of omics approaches, and highlighted the latest advancements in employing multi‐omics techniques for forensic investigations.

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Section: Proteomics For Personal Identificationmentioning

confidence: 99%

“…Similarly, Mays et al. [335] identified the sex of highly degraded skeletal remains dated 1 st century BCE overcoming the limitation posed by high‐throughput DNA sequencing, that failed as no aDNA survived in such remains. Olszewski et al.…”

Section: Omics In Forensic Sciencesmentioning

confidence: 99%

From flesh to bones: Multi‐omics approaches in forensic science

Procopio,

Bonicelli

2024

Proteomics

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No Bones About It: Sex Is Binary

Weiss

2024

Arch Sex Behav

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Detection of chromosomal aneuploidy in ancient genomes

Anastasiadou,

Silva,

Booth

et al. 2024

Commun Biol

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Ancient DNA is a valuable tool for investigating genetic and evolutionary history that can also provide detailed profiles of the lives of ancient individuals. In this study, we develop a generalised computational approach to detect aneuploidies (atypical autosomal and sex chromosome karyotypes) in the ancient genetic record and distinguish such karyotypes from contamination. We confirm that aneuploidies can be detected even in low-coverage genomes ( ~ 0.0001-fold), common in ancient DNA. We apply this method to ancient skeletal remains from Britain to document the first instance of mosaic Turner syndrome (45,X0/46,XX) in the ancient genetic record in an Iron Age individual sequenced to average 9-fold coverage, the earliest known incidence of an individual with a 47,XYY karyotype from the Early Medieval period, as well as individuals with Klinefelter (47,XXY) and Down syndrome (47,XY, + 21). Overall, our approach provides an accessible and automated framework allowing for the detection of individuals with aneuploidies, which extends previous binary approaches. This tool can facilitate the interpretation of burial context and living conditions, as well as elucidate past perceptions of biological sex and people with diverse biological traits.

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Sex identification of a Late Iron Age sword and mirror cist burial from Hillside Farm, Bryher, Isles of Scilly, England

Cited by 4 publications

References 40 publications

From flesh to bones: Multi‐omics approaches in forensic science

From flesh to bones: Multi‐omics approaches in forensic science

No Bones About It: Sex Is Binary

Detection of chromosomal aneuploidy in ancient genomes

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