Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

Abstract

AIMTo investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps.METHODSA retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colonoscopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps.RESULTSThe prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95%CI: 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95%CI: 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95%CI: 1.18-2.00, P < 0.05; OR = 1.42, 95%CI: 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95%CI: 0.18-1.04, P > 0.05; OR = 1.18, 95%CI: 0.50-2.78, P > 0.05).CONCLUSIONNAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women.

Association between nonalcoholic fatty liver disease and extrahepatic cancers: a systematic review and meta-analysis

“…4b). Furthermore, the results of subgroup analysis showed that the pooled OR of colorectal adenoma in the cross-sectional studies [28,30,31,[34][35][36]47] was 1.36 (95% CI: 1.28-1.45), and in the cohort studies [29,33] it was 1.55 (95% CI: 1.18-2.03) ( Table 1, Fig. 2b).…”

“…To investigate the association of NAFLD and the risk of colorectal adenoma, pooled OR of colorectal adenomas from nine studies was analyzed [28][29][30][31][32][33][34][35][36]47]. A meta-analysis was conducted with the random-effect effect model (P = 0.045, I 2 = 49.4%).…”

Association between nonalcoholic fatty liver disease and extrahepatic cancers: A systematic review and meta-analysis

“…When publication bias was tested, Begg's test indicated no obvious publication bias (P = 0.754) ( Figure 4B). Furthermore, the results of subgroup analysis showed that the pooled OR of colorectal adenoma in the cross-sectional studies [28,30,31,[34][35][36]47] was 1.36 (95% CI: 1.28-1.45), and in the cohort studies [29,33] Figure 2B). These results suggest that patients with NAFLD have a higher risk of developing colorectal cancer and colorectal adenoma than patients without NAFLD.…”

Association between nonalcoholic fatty liver disease and extrahepatic cancers: A systematic review and meta-analysis

“…When publication bias was tested, Begg's test indicated no obvious publication bias (P = 0.754) ( Figure 4B). Furthermore, the results of subgroup analysis showed that the pooled OR of colorectal adenoma in the cross-sectional studies [28,30,31,[34][35][36]47] was 1.35 (95% CI: 1.17-1.55), and in the cohort studies [29,33] Figure 2B). These results suggest that patients with NAFLD have a higher risk of developing colorectal cancer and colorectal adenoma than patients without NAFLD.…”