Sex of the first‐born and obstetric complications in the subsequent birth. A study of 2.3 million second births from Denmark, Finland, Norway, and Sweden

Mortensen, Laust Hvas; Cnattingius, Sven; Gissler, Mika; Klungsøyr, Kari; Skjærven, Rolv; Andersen, Anne‐Marie Nybo; Nielsen, Henriette Svarre

doi:10.1111/aogs.13872

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…Sweden had the highest number of eligible studies (44 studies), 14,21–63 followed by Denmark (29 studies), 15,33,52,64–89 Norway (26 studies), …”

Section: Resultsmentioning

confidence: 99%

“…Sweden had the highest number of eligible studies (44 studies), 14, followed by Denmark (29 studies), 15,33,52, Norway (26 studies), 16,33,52,54,59,74,84,[90][91][92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107][108] Finland (19 studies), 16,33,52,71,[108][109][110][111][112][113][114][115][116][117][118][119][120][121][122] and Iceland (four studies). 33,[123]…”

Section: Identification Of Studies and Quality Appraisalmentioning

confidence: 99%

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Prevalence of preterm birth in Scandinavian countries: a systematic review and meta-analysis

Behboudi-Gandevani,

Bidhendi-Yarandi,

Hossein Panahi

et al. 2023

J Int Med Res

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Objectives As welfare societies, Scandinavian countries share characteristics of equality related to healthcare access, gender, and social services. However, cultural and lifestyle variations create country-specific health differences. This meta-analysis assessed the prevalence of preterm birth (PTB) and its categories in Scandinavian countries. Methods A systematic search in key databases of literature published between 1990 and 2021 identified studies of the prevalence of PTB and its categories. Following the use of the Freeman–Tukey double arcsine transformation, a meta-analysis of weighted data was performed using the random-effects model and meta-prop method. Results We identified 109 observational studies that involved 86,420,188 live births. The overall pooled prevalence (PP) of PTB was 5.3% (PP = 5.3%, 95% confidence interval [CI] 5.1%, 5.5%). The highest prevalence was in Norway (PP = 6.2%, 95% CI 5.3%, 7.0%), followed by Sweden (PP = 5.3%, 95% CI 5.1%, 5.4%), Denmark (PP = 5.2%, 95% CI 4.9%, 5.3%), and Iceland (PP = 5.0%, 95% CI 4.4%, 5.7%). Finland had the lowest PTB rate (PP = 4.9%, 95% CI 4.7%, 5.1%). Conclusions The overall PP of PTB was 5.3%, with small variations among countries (4.9%–6.2%). The highest and lowest PPs of PTB were in Norway and Finland, respectively.

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“…Sweden had the highest number of eligible studies (44 studies), 14,21–63 followed by Denmark (29 studies), 15,33,52,64–89 Norway (26 studies), …”

Section: Resultsmentioning

confidence: 99%

Section: Identification Of Studies and Quality Appraisalmentioning

confidence: 99%

Prevalence of preterm birth in Scandinavian countries: a systematic review and meta-analysis

Behboudi-Gandevani,

Bidhendi-Yarandi,

Hossein Panahi

et al. 2023

J Int Med Res

View full text Add to dashboard Cite

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“…lower pregnancy estrogen levels of women carrying males (Toriola et al, 2011 ). Additionally, the fetal male sex has been previously associated with higher risk of obstetric complications (Mortensen et al, 2020 ). Put together, obstetric complications and antidepressant-related neonatal withdrawal syndrome may be related to the well-established notion of poorer adaptation of male than female fetuses to suboptimal uterine environments (DiPietro & Voegtline, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Neonatal withdrawal syndrome following in utero exposure to antidepressants: a disproportionality analysis of VigiBase, the WHO spontaneous reporting database

et al. 2022

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Background Evidence on neonatal withdrawal syndrome following antidepressant intrauterine exposure is limited, particularly for antidepressants other than selective serotonin reuptake inhibitor (SSRIs). Methods In our case/non-case pharmacovigilance study, based on VigiBase®, the WHO database of suspected adverse drug reactions, we estimated reporting odds ratio (ROR) and the Bayesian information component (IC) with 95% confidence/credibility intervals (CI) as measures of disproportionate reporting of antidepressant-related neonatal withdrawal syndrome. Antidepressants were first compared to all other medications, then to methadone, and finally within each class of antidepressants: SSRIs, tricyclics (TCA) and other antidepressants. Antidepressants were ranked in terms of clinical priority, based on semiquantitative score ratings. Serious v. non-serious reports were compared. Results A total of 406 reports of neonatal withdrawal syndrome in 379 neonates related to 15 antidepressants were included. Disproportionate reporting was detected for antidepressants as a group as compared to all other drugs (ROR: 6.18, 95% CI 5.45–7.01, IC: 2.07, 95% CI 1.92–2.21). Signals were found for TCAs (10.55, 95% CI 8.02–13.88), followed by other antidepressants (ROR: 5.90, 95% CI 4.74–7.36) and SSRIs (ROR: 4.68, 95% CI 4.04–5.42). Significant disproportionality emerged for all individual antidepressants except for bupropion, whereas no disproportionality for any antidepressant was detected v. methadone. Eleven antidepressants had a moderate clinical priority score and four had a weak one. Most frequent symptoms included respiratory symptoms (n = 106), irritability/agitation (n = 75), tremor (n = 52) and feeding problems (n = 40). Conclusions Most antidepressants are associated with moderate signals of disproportionate reporting for neonatal withdrawal syndrome, which should be considered when prescribing an antidepressant during pregnancy, irrespective of class.

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“…While national registers offer the possibility of creating birth cohorts of an order of magnitude larger than the EU Child Cohort (for e.g. Nordic register-based cohort studies [ 64 , 65 ]), these typically lack the in-depth lifestyle and behavioural data obtained from questionnaires, or physiological data obtained from detailed clinical examinations. National register data are in addition likely to offer less diversity with respect to social, cultural and political environment.…”

Section: Discussionmentioning

confidence: 99%

The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

et al. 2021

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The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.

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Sex of the first‐born and obstetric complications in the subsequent birth. A study of 2.3 million second births from Denmark, Finland, Norway, and Sweden

Cited by 3 publications

References 25 publications

Prevalence of preterm birth in Scandinavian countries: a systematic review and meta-analysis

Prevalence of preterm birth in Scandinavian countries: a systematic review and meta-analysis

Neonatal withdrawal syndrome following in utero exposure to antidepressants: a disproportionality analysis of VigiBase, the WHO spontaneous reporting database

The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

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