Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila

Yang, Yan; Hu, Shao Wei; Li, Xiaonan; Sun, Yuanjie; He, Ping; Kohlmeier, Kristi A.; Zhu, Yan

doi:10.1016/j.isci.2023.106123

Cited by 3 publications

(5 citation statements)

References 69 publications

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“…Within the female’s reproductive tract, sensory neurons responsive to sex peptide detect its presence and convey the signal to the SP-abdominal ganglia neurons and to myoinhibitory peptide interneurons. Concurrently, SP suppresses the activity of serotonergic projection neurons, leading to a decline in female receptivity ( 54 – 57 ).…”

Section: Precopulatory Neural Mechanismsmentioning

confidence: 99%

“…In the cricket Teleogryllus oceanicus , the seminal proteins ToSfp022 and ToSfp0 appear to be responsible for reducing mate-seeking behavior, as females mated with males with a knockdown in the ToSfp022 and ToSfp01 genes left their nest significantly more frequently in response to male courtship songs compared to those mated with control males ( 24 ). While the mechanism of action of these proteins remains unclear, evidence suggests they interact with the female nervous system in a manner similar to sex peptide in Drosophila ( 23 , 54 , 57 ).…”

Section: Copulatory Neural Mechanismsmentioning

confidence: 99%

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Neural mechanisms involved in female mate choice in invertebrates

Cordero-Molina,

Fetter-Pruneda,

Contreras-Garduño

2024

Front. Endocrinol.

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Mate choice is a critical decision with direct implications for fitness. Although it has been recognized for over 150 years, our understanding of its underlying mechanisms is still limited. Most studies on mate choice focus on the evolutionary causes of behavior, with less attention given to the physiological and molecular mechanisms involved. This is especially true for invertebrates, where research on mate choice has largely focused on male behavior. This review summarizes the current state of knowledge on the neural, molecular and neurohormonal mechanisms of female choice in invertebrates, including behaviors before, during, and after copulation. We identify areas of research that have not been extensively explored in invertebrates, suggesting potential directions for future investigation. We hope that this review will stimulate further research in this area.

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Section: Precopulatory Neural Mechanismsmentioning

confidence: 99%

Section: Copulatory Neural Mechanismsmentioning

confidence: 99%

Neural mechanisms involved in female mate choice in invertebrates

Cordero-Molina,

Fetter-Pruneda,

Contreras-Garduño

2024

Front. Endocrinol.

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“…SP is provided along the ejaculate and is bound to the sperm tail in the female reproductive tract (Chen et al, 1988; Peng et al, 2005; Misra et al, 2022). After mating, when sperm is stored, SP is cleaved away from sperm and released into female reproductive tract, binding to SP receptors and passing a signal to the brain (Peng et al, 2005; Yapici et al, 2008; Yang et al, 2009; Rezával et al, 2012; Kubli & Bopp, 2012; Yang et al, 2023). The consequence is an increase in female activity, aggression, a reduction of the rest periods, a reduction in remating (Hopkins & Perry, 2022; Yang et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

“…After mating, when sperm is stored, SP is cleaved away from sperm and released into female reproductive tract, binding to SP receptors and passing a signal to the brain (Peng et al, 2005; Yapici et al, 2008; Yang et al, 2009; Rezával et al, 2012; Kubli & Bopp, 2012; Yang et al, 2023). The consequence is an increase in female activity, aggression, a reduction of the rest periods, a reduction in remating (Hopkins & Perry, 2022; Yang et al, 2023). SP also increases the synthesis of the juvenile hormone (JH) and stimulates egg production and oocyte maturation (Moshitzky et al, 1996; Berg et al, 2024).…”

Section: Introductionmentioning

confidence: 99%

Can seminal fluid proteins be honest signals of sperm availability?

Michalak,

Duneau,

Ferdy

2024

Preprint

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Seminal fluid proteins (Sfps) are produced by males, yet they have significant effects on female physiology and behaviour. Sfps are often viewed as a mechanism for males to manipulate female reproductive behaviours,but despite many studies identifying their varied effects and their molecular underpinnings, the ways males and females use Sfps remain unclear. In the most studied case of Drosophila melanogaster particular peptides within the seminal fluid have been identified to guide female reproduction: sex peptide (SP, Acp70A) is known to induce changes in egg production, oviposition and remating and is attached to sperm and continuously supplied for days after mating, while ovulation inducing peptide, ovulin (Acp26Aa), is a free peptide with only short term effects after mating. Using a biologically informed model we show how these peptides can synchronize sperm and egg release, hence reducing the number of unfertilized eggs a female lays. We further show that the exhaustion of SP might be the key signal of this synchronization. Finally, we demonstrate that sexual conflict over the regulation of female reproductive physiology by Sfps should be limited, with the primary conflict probably centring around the regulation of remating behaviour.

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“…Previous research in Poecilia reticulata has revealed differential gene expression in the brains of females in response to male attractiveness (i.e., colorful vs. dull males; Bloch et al, 2018). Similarly, studies on Drosophila have explored the neural circuits and differential gene expression in females' brains related to male courtship and/or female receptivity (Baker et al, 2022; Immonen & Ritchie, 2012; Kohl et al, 2013; Mezzera et al, 2020; Ning et al, 2022; Ohashi et al, 2023; Pacheco et al, 2021; Wang et al, 2020; Yang et al, 2023). However, much investigation is still needed to understand how male attractiveness affects the underlying mechanisms in female brains and their association with mate rejection and offspring production.…”

Section: Introductionmentioning

confidence: 99%

The females' response to male attractiveness: Mate choice, larvae production and differential brain protein expression

Hernández‐Villanueva,

Cordero‐Molina,

Macías García

et al. 2023

Ethology

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Sexual Selection has been studied predominantly from a functional perspective with relatively limited investigation of the mechanistic basis of female choice. In this study, we evaluated female choice and larvae production in response to attractive or less attractive males and concurrently examined the protein profile in the brains of females, using the mealworm beetle Tenebrio molitor as a model system. Females were found to prefer males with high levels of pheromones, which requires the secretion of juvenile hormone (JH). Male attractiveness was enhanced using the JH analog methoprene, resulting in less female rejection and higher mating frequency and offspring production. Importantly, reproductive success was not due to differences in testis size or sperm production, or viability. Out of the 1833 proteins detected in the brain, only 32 were differentially expressed in females mating with attractive versus less attractive males. These proteins involved memory, metabolism, olfactory detection, reproduction, and movement. Although some brain proteins have been linked to mate choice in vertebrates, most of the differentially expressed molecules found in this study have not been previously reported concerning mate choice.

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Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila

Cited by 3 publications

References 69 publications

Neural mechanisms involved in female mate choice in invertebrates

Neural mechanisms involved in female mate choice in invertebrates

Can seminal fluid proteins be honest signals of sperm availability?

The females' response to male attractiveness: Mate choice, larvae production and differential brain protein expression

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