Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

MacDonald, Kai

doi:10.3389/fnins.2012.00194

Cited by 96 publications

(108 citation statements)

References 146 publications

(165 reference statements)

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“…This raised the question whether and how the current effect can be generalized to other populations. Previous studies have shown differential or even opposing oxytocin effects between males and females (Macdonald, 2012;Fischer-Shofty et al, 2013;Rilling et al, 2014). Gender differences were also observed in ingroup favoritism (van Vugt et al, 2007;Charness and Rustichini, 2011).…”

Section: Discussionmentioning

confidence: 51%

“…Participants were instructed to refrain from smoking or drinking (except water) for 2 h before the experiment. Previous studies reported gender differences in both oxytocin function (Macdonald, 2012;Fischer-Shofty et al, 2013;Rilling et al, 2014) and ingroup favoritism (van Vugt et al, 2007;Charness and Rustichini, 2011). In addition, studies examining oxytocin effects on social cognition and behaviors have been conducted mainly with men (van IJzendoorn and Bakermans-Kranenburg, 2012).…”

Section: Participantsmentioning

confidence: 99%

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Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds

Liu

Rand

et al. 2015

Neuropsychopharmacol

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People often favor ingroup over outgroup members when choosing to cooperate. Such ingroup-favored cooperation is promoted by oxytocin-a neuropeptide shown to facilitate social cognition and that has emerged as a pharmacological target for treatments of social functioning deficits. The current study applied a dual-process model to investigate whether and how intuitive and reflective cognitive styles affect the oxytocin-motivated ingroup favoritism in cooperation. We examined oxytocin effects on ingroup favoritism in a double-blind, placebo-controlled between-subjects design where cognitive processing (intuition vs reflection) was experimentally manipulated in healthy Chinese males (n = 150). We also supplemented this experimental manipulation with an individual difference analysis by assessing participants' inclination toward intuition or reflection in daily life. Intranasal administration of oxytocin (vs placebo) increased ingroup favoritism among participants primed to be intuitive or those who preferred intuition in daily life. In contrast, oxytocin decreased ingroup favoritism in participants primed to rely on reflective thinking or those who preferred reflective decision-making in daily life. Our results demonstrate that oxytocin has distinct functional roles when different cognitive styles (ie, intuition vs reflection) are promoted during social cooperation in a group situation. Our findings have implications for oxytocin pharmacotherapy of social dysfunction in that whether the effects of oxytocin on social functioning are facilitative, debilitative, or null, depends on an individual's cognitive style.

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Section: Discussionmentioning

confidence: 51%

Section: Participantsmentioning

confidence: 99%

Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds

Liu

Rand

et al. 2015

Neuropsychopharmacol

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show abstract

“…From a neuroendocrine perspective, oxytocin is known to be an important mediator of social behavior and emotional recognition, and an improvement in behavior in bvFTD patients has been suggested with administration of oxytocin [44]. Oxytocin through interactions with gonadal hormones has also been suggested to affect sexual function [45], with decreased levels or action potentially producing decreased sexual drive. When bvFTD patients are administered oxytocin a proportion develop hypersexual behavior [46].…”

Section: Discussionmentioning

confidence: 99%

Characterizing Sexual Behavior in Frontotemporal Dementia

Kaizik

Irish

Mioshi

et al. 2015

JAD

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Abstract.Background: Frontotemporal dementia (FTD) is characterized by a number of prominent behavioral changes. While FTD has been associated with the presence of aberrant or unusual sexual behaviors in a proportion of patients, few studies have formally investigated changes in sexual function in this disease. Objective: We aimed to systematically quantify changes in sexual behavior, including current symptoms and changes from prior diagnoses, in behavioral-variant (bvFTD) and semantic dementia (SD), compared to Alzheimer's disease (AD). Methods: Carers of 49 dementia patients (21 bvFTD, 11 SD, 17 AD) were interviewed using the Sexual Behavior and Intimacy Questionnaire (SIQ), a survey designed to assess changes in sexual function across multiple domains including initiating, level of affection, and aberrant or unusual sexual behavior. Results: BvFTD patients show prominent hyposexual behavior including decreased affection, initiation, and response to advances by partners, and decreased frequency of sexual relations, compared to AD and to SD patients. The greatest changes in sexual behavior compared to pre-diagnoses were found in the bvFTD group with a 90-100% decrease in initiation, response, and frequency of sexual relations. Notably, aberrant or unusual sexual behavior was reported in a minority of bvFTD and SD patients and occurred in patients who also showed hyposexual behavior toward their partner. Conclusion: Overall loss of affection, reduced initiation of sexual activity, and responsiveness is an overwhelming feature of bvFTD. In contrast, aberrant or unusual sexual behavior is observed in the minority of bvFTD patients. The underlying pathophysiology of these changes likely reflects structural and functional changes in frontoinsular and limbic regions including the hypothalamus.

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“…A ocitocina (OT) é um hormônio peptideo liberado pela neurohipófise relacionada a uma ampla variedade de efeitos fisiológicos centrais e periféricos (SHEPARD et al, 2009;FELDMAN;VIERO et al, 2010;GORDON et al, 2011;EBSTEIN et al, 2012;FELDMAN, 2012;LOPATINA et al, 2012;CARSON et al, 2013 1 ), influenciando em diversos níveis na reprodução de todos os vertebrados (ANOUAR et al, 1996;OSTROWSKI, 1998;INABA et al, 1999;GIMPL;FAHRENHOLZ, 2001;FILIPPI et al, 2002;THACKARE;WHITTINGTON, 2006;VIERO et al, 2010;DEBLON et al, 2011;GARRISON et al, 2012;MACDONALD, 2012). Este hormônio exerce um papel fundamental na contração do miométrio no momento do parto e na contração das células mioepiteliais da glândula mamária permitindo a ejeção do leite e lactação, apresentando receptores que circundam os alvéolos e ductos mamários (ANOUAR et al, 1996;FUCHS et al, 1996;REZAPOUR;BACKSTROM;ULMSTEN, 1996;ZINGG, 1996;IVELL, 1997;KIMURA et al, 1998;INABA et al, 1999;BAE;WATSON, 2003;THACKARE;WHITTINGTON, 2006;PRETZER, 2008;LEE et al, 2009;GORDON et al, 2010;LUI et al, 2010;DEBLON et al, 2011;MAGON;…”

Section: Introductionunclassified

“…Outras funções da OT incluem os efeitos no sistema cardiovascular (HATAMI;VALOJERDI;MOWLA, 2007;AHMED;ELOSAILY, 2011;LOPATINA et al, 2012), a regulação da proliferação celular em diferentes tecidos (PETERSSON et al, 2002;HATAMI;VALOJERDI;MOWLA, 2007;SENDEMIR et al, 2008;ZHONG et al, 2010;VRACHNIS et al, 2011), e os efeitos no sistema nervoso central relacionados ao aprendizado, memorização, estresse, desordens neuropsiquiátricas, tendo um papel chave no comportamento social e relacionamento entre os mamíferos (OSTROWSKI, 1998;UVNAS-MOBERG et al, 2001;PRETZER, 2008;SHEPARD et al, 2009;YOUNG, 2009;GORDON et al, 2010;BOWEN et al, 2011;CHEN et al, 1,2 CARSON, D. S.; GUASTELLA, A. J.; TAYLOR, E. R.; MCGREGOR, I. S. A brief history of oxytocin and its role in modulating psychostimulant effects. Journal Psychopharmacology, GORDON et al, 2011;MAGON;KALRA, 2011;TOPS et al, 2011;EBSTEIN et al, 2012;FELDMAN, 2012;LOPATINA et al, 2012;MACDONALD, 2012;POULIN;HOLMAN, 2013 3 ; POURNAJAFI-NAZARLOO et al, 2013 4 ).…”

Section: Introductionunclassified

Imunolocalização dos receptores de ocitocina no testículo e epidídimo de cães

Minazaki¹

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DEDICATÓRIADedico este trabalho a minha família que esteve sempre presente em todos os momentos e compartilharam de todas as minhas conquistas durante este doutorado. A meus pais Takeshi e Toshie, minhas irmãs Cristina, Célia, Ana Márcia, meus cunhados Carlos Pereira, Ricardo e Carlos Gennari, meus sobrinhos Rafael, Liliana, Ana Beatriz e Gustavo sinceros agradecimentos por todo apoio. A expressão dos receptores da ocitocina (OTR) em machos, embora estudada em algumas espécies, não foi ainda estabelecida em cães. O objetivo deste estudo foi trazer novas perspectivas para a utilização terapêutica da ocitocina (OT) em patologias reprodutivas em cães já que tem sido utilizada no tratamento da infertilidade em homens. Foi realizada a imunolocalização dos receptores de OTR em amostras de testículo e epidídimo de cães coletadas por cirurgia eletiva de orquiectomia e fixadas em formaldeído tamponado a 10%. Seguiu-se o processamento histológico de rotina, desparafinização, desidratação e recuperação de sítios antigênicos. A incubação foi feita com o anticorpo primário anti-OTR humano policlonal produzido em coelho e o polímero NOVOLINK da Nicherei®. A imunomarcação foi observada nas células mioepiteliais, células da musculatura lisa do estroma e nas células de Leydig no testículo e muito mais intensa nas células da musculatura lisa da região do epidídimo. A expressão dos OTR demonstrou-se maior no epidídimo quando comparada ao testículo. A distribuição dos OTR na imunomarcação e no western blotting reforçam os dados da literatura que sugerem ação da ocitocina no estímulo da contratilidade dos túbulos seminíferos e epidídimo, assim como seu papel na modulação dos níveis de androgênios nestes tecidos estimulando a conversão da testosterona em diidrotestosterona (DHT). Nossos resultados corroboram com a literatura permitindo que o conhecimento da distribuição das OTR no testículo e epidídimo de cães possibilite a utilização terapêutica da ocitocina e novas perspectivas para a área de reprodução e biotecnologia de cães. AGRADECIMENTOSPalavras chave: Ocitocina. Receptor de ocitocina. Infertilidade. The expression of oxytocin receptors (OTR) in the male reproductive tract has been studied in several species with the exception of the dogs. In men, oxytocin (OT) therapy has been successfully used to treat infertility. Therefore, the aim of the present study was to provide new perspectives for the therapeutic use of oxytocin (OT) in reproductive disorders in dogs. We performed the immunolocalization of OTR in samples of testis and epididymides of dogs collected by elective orchiectomy and fixed in 10% buffered formaldehyde. This was followed by routine histological processing, deparaffinization, dehydration and recovery of antigenic sites. Incubation was performed with the human polyclonal anti-OTR primary antibody produced in rabbits and the NOVOLINK polymer (Nichirei, Japan). Oxytocin receptor Immunostaining was observed in myoepithelial, smooth muscle, stromal, and Leydig cells in the testis and, a more intense staining was f...

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Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin

Cited by 96 publications

References 146 publications

Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds

Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds

Characterizing Sexual Behavior in Frontotemporal Dementia

Imunolocalização dos receptores de ocitocina no testículo e epidídimo de cães

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